Effect of adjunctive treatment with intravenously administered Propionibacterium acnes on reproductive performance in mares with persistent endometritis.
Abstract: To determine whether treatment with a preparation of Propionibacterium acnes would improve pregnancy and live foal rates in mares with persistent endometritis. Methods: Randomized placebo-controlled clinical trial. Methods: 95 mares with a cytologic diagnosis of persistent endometritis. Methods: Mares were treated with P acnes or placebo (both administered IV) on days 0, 2, and 6. No attempt was made to alter additional treatments administered by attending veterinarians. Information on breeding history, physical examination findings, results of cytologic examination and microbial culture of uterine samples, additional treatments administered, breeding dates, results of pregnancy examinations, whether a live foal was produced, and reactions to treatment was recorded. Results: In multivariate logistic regression models, mare age, year of entry into the study, and first breeding within 8 days after first treatment with P acnes or placebo were significantly associated with pregnancy. Fewer number of cycles bred and younger age were significantly associated with delivery of a live foal in a separate multivariate analysis. Results of multivariate logistic regression modeling indicated that mares treated with P acnes were more likely to become pregnant and to deliver a live foal, compared with placebo-treated controls. Conclusions: IV administration of P acnes as an adjunct to conventional treatments in mares with a cytologic diagnosis of persistent endometritis improved pregnancy and live foal rates. The optimal effect was detected in mares bred during the interval extending from 2 days before to 8 days after first treatment with P acnes.
Publication Date: 2007-07-04 PubMed ID: 17605673DOI: 10.2460/javma.231.1.107Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This study evaluated the positive impact of intravenously administered Propionibacterium acnes on improving pregnancy and live foal birth rates in mares suffering from persistent endometritis.
Study Setup and Methodology
- The randomized, placebo-controlled clinical trial involved 95 mares diagnosed with persistent endometritis.
- These mares were treated with either Propionibacterium acnes (P acnes) or a placebo on the 0th, 2nd, and 6th days. The substances were administered intravenously (IV).
- The researchers did not interfere with any additional treatments given by the attending veterinarians.
- Data regarding the mares’ breeding history, cytologic examination and microbial culture results of uterine samples, additional treatments, breeding dates, results of pregnancy tests, live foal births, and reactions to treatment were recorded.
Results of the Study
- Multivariate logistic regression models revealed that a mare’s age, the year she joined the study, and her first breeding occurring within 8 days after the first treatment with P acnes or placebo had significant associations with successful pregnancy.
- Another separate multivariate analysis showed that younger mares and those that went through fewer breeding cycles were significantly more likely to give birth to a live foal.
- Mares treated with P acnes had a higher probability of becoming pregnant and delivering a live foal compared to those receiving the placebo treatment, according to the results from the multivariate logistic regression models.
Conclusion
- The injection of P acnes improved both the pregnancy rate and live foal birth rate of mares diagnosed with persistent endometritis. This supported the use of P acnes as an adjunct to conventional treatment procedures.
- The best results were observed in mares that were bred within a 2-day period before to 8 days after receiving their first P acnes treatment.
Cite This Article
APA
Rohrbach BW, Sheerin PC, Cantrell CK, Matthews PM, Steiner JV, Dodds LE.
(2007).
Effect of adjunctive treatment with intravenously administered Propionibacterium acnes on reproductive performance in mares with persistent endometritis.
J Am Vet Med Assoc, 231(1), 107-113.
https://doi.org/10.2460/javma.231.1.107 Publication
Researcher Affiliations
- Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
MeSH Terms
- Age Factors
- Animals
- Breeding
- Endometritis / therapy
- Endometritis / veterinary
- Female
- Horse Diseases / therapy
- Horses
- Injections, Intravenous / veterinary
- Logistic Models
- Multivariate Analysis
- Pregnancy
- Pregnancy Outcome / veterinary
- Pregnancy Rate
- Probiotics / therapeutic use
- Propionibacterium acnes / growth & development
- Reproduction / drug effects
- Reproduction / physiology
Citations
This article has been cited 2 times.- Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology. Int J Mol Sci 2020 Feb 20;21(4).
- Bruhn O, Grötzinger J, Cascorbi I, Jung S. Antimicrobial peptides and proteins of the horse--insights into a well-armed organism. Vet Res 2011 Sep 2;42(1):98.
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