Effect of age, feeding, and omeprazole administration on gastric tonometry in healthy neonatal foals.
Abstract: Gastric tonometry is commonly used in humans as an assessment of intestinal mucosal perfusion. Values in healthy foals are currently unknown. Objective: Age, enteral feeding, and omeprazole administration would significantly alter gastric tonometry measurements in neonatal foals. Methods: Nine clinically normal foals were used to assess the effect of age and feeding, and 8 similar foals were used to assess the effect of omeprazole. Methods: At 1, 7, and 14 days of age, gastric intramucosal PCO2 (PgCO2) and arterial blood gas samples were obtained at baseline, immediately after feeding milk, and 1 and 2 hours after fasting for calculation of the intramucosal-arterial PCO2 difference (DeltaCO2). To evaluate the effect of omeprazole, foals were evaluated twice as above, 2 hours after fasting, comparing administration of omeprazole to no drug. Results: There was a significant effect of age and feeding on PgCO2 and DeltaCO2, whereas arterial PCO2 was not significantly affected by these factors. Postfeeding DeltaCO2 values were significantly lower than fasted values. Baseline and postfeeding DeltaCO2 increased with age. There was no significant effect of age on data collected after 1 or 2 hours of fasting. The 90% reference interval for DeltaCO2 data collected after fasting was 0-54 mmHg. Foals had a significantly higher mean gastric pH and significantly higher DeltaCO2 and PgCO2 following omeprazole relative to no treatment. Conclusions: Because of the high and variable DeltaCO2, which is exacerbated by omeprazole administration, the reference interval in foals is extremely wide.
Publication Date: 2008-03-29 PubMed ID: 18371031DOI: 10.1111/j.1939-1676.2008.0065.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigated the impacts of age, food intake, and the administration of the drug omeprazole on gastric tonometry measurements in newborn horses. The study found that age and feeding do significantly alter these measurements, while the drug greatly increased the variability of these measurements.
Research Procedures
- The research utilized two groups of healthy foals (a young horse), composed of nine foals for the purposes of evaluating the effect of age and feeding and eight additional foals to analyze the influence of omeprazole administration.
- The research was conducted by observing each foal at 1, 7, and 14 days of age while comparing differences in gastric intramucosal PCO2 (PgCO2) and arterial blood gas levels at baseline, directly after milk feeding, and 1 and 2 hours after fasting.
- To evaluate the potential effects of omeprazole, the same foals were re-evaluated twice under fasting conditions, comparing the measurements after the administration of omeprazole with a control group.
Results of the Research
- The research discovered a significant effect of age and feeding on PgCO2 and DeltaCO2, though arterial PCO2 was not significantly impacted by these factors.
- The DeltaCO2 measurements were found to be much lower post-feeding compared to fasted measurements. Additionally, baseline and postfeeding DeltaCO2 increased as the foals grew older.
- No notable effect of age was seen on the measurements taken after 1 or 2 hours of fasting.
- Following the fasting period, the fasting reference interval for DeltaCO2 measurements in the foals was established between 0-54 mmHg.
- The administration of omeprazole resulted in a notably higher mean gastric pH and significantly higher DeltaCO2 and PgCO2 when compared against a control group.
Conclusions of the Research
- The research concluded that due to the high and variable DeltaCO2 readings, that are further exacerbated by omeprazole administration, the reference interval (the range of values expected in a healthy individual) for foals is extremely broad.
Cite This Article
APA
Sanchez LC, Giguère S, Javsicas LH, Bier J, Walrond CJ, Womble AY.
(2008).
Effect of age, feeding, and omeprazole administration on gastric tonometry in healthy neonatal foals.
J Vet Intern Med, 22(2), 406-410.
https://doi.org/10.1111/j.1939-1676.2008.0065.x Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136, USA. sanchezl@vetmed.ufl.edu
MeSH Terms
- Age Factors
- Aging / physiology
- Animals
- Anti-Ulcer Agents / pharmacology
- Carbon Dioxide / metabolism
- Enteral Nutrition / veterinary
- Gastrointestinal Motility / drug effects
- Horses / physiology
- Manometry / veterinary
- Omeprazole / pharmacology
- Random Allocation
- Reference Values
- Stomach / drug effects
- Stomach / physiology
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