Effect of exercise on concentrations of immunoreactive endothelin in bronchoalveolar lavage fluid of normal horses and horses with chronic obstructive pulmonary disease.
Abstract: Chronic obstructive pulmonary disease (COPD) represents a major cause of loss of performance in the horse. The role of endothelin (ET), a potent bronchoconstrictive and vasoactive peptide, is currently being investigated in asthma and other obstructive respiratory diseases in man. We have previously found elevated systemic and pulmonary endothelin levels in horses during exacerbation of COPD. In the present study, our aim was to examine possible variations in ET concentrations occurring during exercise in COPD horses. We compared the effects of intense treadmill exercise on the recovery of endothelin (ET) in the bronchoalveolar lavage fluid (BALF) as well as in arterial and venous blood, in a group of 5 healthy horses and a group of 5 COPD horses studied alternately in remission and while symptomatic. We also investigated the possible correlations between ET levels and pulmonary function tests during the study. While exercise did not affect the ET levels recovered in BALF among controls, it caused a significant increase (P = 0.02) among symptomatic COPD horses. During remission, wide variations of ET levels among horses, at rest and during exercise, made any significant interpretation difficult. No correlation could be found between exercise-induced changes in ET concentrations and pulmonary function tests or changes in arterial oxygen tension with exercise. We conclude that exercise appears to affect the release of ET by the airways in COPD horses, in contrast to healthy horses. It is still unclear, however, whether these differences relate to adjustments of lung function during exercise.
Publication Date: 2000-02-05 PubMed ID: 10659230DOI: 10.1111/j.2042-3306.1999.tb05196.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper investigates how exercise affects the levels of endothelin, a peptide involved in respiratory diseases, in horses with and without chronic obstructive pulmonary disease (COPD). The findings reveal that exercise significantly increases the levels of endothelin in symptomatic COPD horses as compared to the healthy ones.
Objective of the Study
- The aim of the study was to explore the possible variations in endothelin concentrations during exercise in horses with COPD. Comparisons were made with a control group of healthy horses to see the differences.
Methodology of the Study
- The research involved a group of 5 healthy horses and a group of 5 horses diagnosed with COPD, each group being alternately studied in remission and while symptomatic.
- Intense treadmill exercise was conducted. Researchers observed the recovery of endothelin in the bronchoalveolar lavage fluid (BALF, a technique to examine cells from the airways), as well as in arterial and venous blood.
- The team also studied the possible correlations between endothelin levels and pulmonary function tests during the study.
Results of the Study
- The research found that while exercise didn’t affect the levels of endothelin in BALF among the control group of horses, there was a significant increase in endothelin levels among symptomatic COPD horses.
- However, during the remission period, the variations in endothelin levels amongst horses, at rest and during exercise, were so wide that any significant interpretation was difficult.
- No specific correlation could be found between changes in endothelin concentrations due to exercise and pulmonary function tests or changes in arterial oxygen tension with exercise.
Conclusion
- The research concluded that exercise appears to affect the release of endothelin by the airways in horses with COPD, contrasting with the behavior seen in healthy horses.
- However, it is still unclear whether these differences relate directly to the adjustments of lung function during exercise.
Cite This Article
APA
Benamou AE, Art T, Marlin DJ, Roberts CA, Lekeux P.
(2000).
Effect of exercise on concentrations of immunoreactive endothelin in bronchoalveolar lavage fluid of normal horses and horses with chronic obstructive pulmonary disease.
Equine Vet J Suppl(30), 92-95.
https://doi.org/10.1111/j.2042-3306.1999.tb05196.x Publication
Researcher Affiliations
- Centre for Equine Studies, Animal Health Trust, Newmarket, Suffolk, UK.
MeSH Terms
- Animals
- Blood Gas Analysis
- Bronchoalveolar Lavage Fluid
- Endothelin-1 / analysis
- Horse Diseases / metabolism
- Horses
- Lung Diseases, Obstructive / metabolism
- Lung Diseases, Obstructive / veterinary
- Physical Conditioning, Animal
- Radioimmunoassay / veterinary
- Respiratory Function Tests / veterinary
- Respiratory Mechanics / physiology
Citations
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