Effect of hydroxyethyl starch infusion on colloid oncotic pressure in hypoproteinemic horses.
Abstract: To determine the effect of hydroxyethyl starch (HES) on colloid oncotic pressure (pi) during fluid resuscitation of hypoproteinemic horses and to evaluate the clinical usefulness of direct and indirect methods for determination of pi before and after infusion of a synthetic colloid. Methods: Prospective clinical study. Methods: 11 hypoproteinemic horses. Methods: Horses received IV infusions of 8 to 10 ml of a 6% solution of HES/kg (3.6 to 4.5 ml/lb) of body weight during fluid resuscitation. Blood samples were obtained for determination of plasma measured colloid oncotic pressure (pi meas) and plasma total protein and albumin (A) concentrations. Plasma globulin concentration (G) was calculated as the difference between plasma total protein and albumin concentrations. Calculated values for colloid oncotic pressure (piA + G) were determined by use of a predictive nomogram previously developed for horses. Results: There was no significant difference between the means of pi meas and piA + G at the beginning of HES infusion. After HES infusion, the mean of pi meas was increased significantly from baseline for 6 hours. Mean plasma total protein and albumin concentrations and piA + G were decreased significantly from baseline for 24 hours. Differences between mean pi meas and piA + G after HES infusion were significant for 24 hours. Conclusions: There was good agreement between plasma pi meas and piA + G in blood samples obtained from hypoproteinemic horses immediately before infusion of HES. Use of a predictive nomogram did not, however, account for the oncotic effect of HES. Results of comparison of pi meas to piA + G after HES infusion suggest that a significant oncotic effect was maintained for 24 hours in the study horses.
Publication Date: 2001-04-25 PubMed ID: 11318365DOI: 10.2460/javma.2001.218.1130Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research evaluates the use of hydroxyethyl starch (HES) in horses with low protein blood levels, assessing its impact on colloid oncotic pressure, an essential factor in fluid balance. The study establishes a significant oncotic effect persisting for 24 hours post HES infusion, though the predictive model used did not account for HES’s oncotic impact.
Objective of the Research
- The main goal of this study was to determine the influence of hydroxyethyl starch (HES) on the colloid oncotic pressure (pi) during the fluid resuscitation of hypoproteinemic horses. Hypoproteinemia refers to an unusually low level of protein in the blood.
- The study also sought to assess the practicality of direct and indirect methods for determining pi, before and after HES infusion.
Research Methods
- The prospective clinical study involved 11 horses suffering from hypoproteinemia.
- The horses were administered IV infusions of a 6% HES solution at 8 to 10 milliliters per kilogram of the horse’s body weight during fluid resuscitation.
- Blood samples were collected to establish plasma measured colloid oncotic pressure, total plasma protein, and albumin concentrations. Plasma globulin concentration was calculated as the difference between total plasma protein and albumin concentrations.
- Using a previously developed nomogram for horses, colloid oncotic pressure derived from albumin and globulin (piA + G) was calculated.
Results of the Study
- The results showed concurrence between pi measured directly from plasma (pi meas) and the value calculated using albumin and globulin (piA + G) prior to HES ingestion. However, such concurrence was absent following HES intake.
- After HES infusion, the mean pi meas was raised significantly and stayed elevated above the baseline for 6 hours.
- Conversely, mean values for total plasma protein and albumin concentrations, along with piA + G, declined notably from baseline and remained low for 24 hours.
- Discrepancies between mean pi meas and piA + G post HES ingestion were noticeable for the same 24 hours.
Conclusions of the Research
- The research concluded that plasma pi meas and piA + G values align in blood samples taken from hypoproteinemic horses immediately before HES infusion.
- However, the predictive nomogram did not accommodate the oncotic influence of HES.
- When comparing pi meas to piA + G post HES infusion, a significant oncotic effect appeared to last for 24 hours in the study horses. These results could have practical implications for the emergency treatment of hypoproteinemia in horses.
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Cite This Article
APA
Jones PA, Bain FT, Byars TD, David JB, Boston RC.
(2001).
Effect of hydroxyethyl starch infusion on colloid oncotic pressure in hypoproteinemic horses.
J Am Vet Med Assoc, 218(7), 1130-1135.
https://doi.org/10.2460/javma.2001.218.1130 Publication
Researcher Affiliations
- Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA.
MeSH Terms
- Animals
- Blood Proteins / analysis
- Colloids
- Fluid Therapy / veterinary
- Horse Diseases / physiopathology
- Horse Diseases / therapy
- Horses
- Hydroxyethyl Starch Derivatives / therapeutic use
- Hypoproteinemia / physiopathology
- Hypoproteinemia / therapy
- Hypoproteinemia / veterinary
- Infusions, Intravenous / veterinary
- Plasma Substitutes / therapeutic use
- Pressure
- Prospective Studies
- Serum Albumin / analysis
- Time Factors
- Treatment Outcome
Citations
This article has been cited 4 times.- Shaw SD, Stämpfli H. Diagnosis and Treatment of Undifferentiated and Infectious Acute Diarrhea in the Adult Horse. Vet Clin North Am Equine Pract 2018 Apr;34(1):39-53.
- Bellezzo F, Kuhnmuench T, Hackett ES. The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease. BMC Vet Res 2014;10 Suppl 1(Suppl 1):S8.
- Wendt-Hornickle EL, Snyder LB, Tang R, Johnson RA. The effects of lactated Ringer's solution (LRS) or LRS and 6% hetastarch on the colloid osmotic pressure, total protein and osmolality in healthy horses under general anesthesia. Vet Anaesth Analg 2011 Jul;38(4):336-43.
- Gomez DE, Kopper JJ, Byrne DP, Renaud DL, Schoster A, Dunkel B, Arroyo LG, Mykkanen A, Gilsenan WF, Pihl TH, Lopez-Navarro G, Tennent-Brown BS, Hostnik LD, Mora-Pereira M, Marques F, Gold JR, DeNotta SL, Desjardins I, Stewart AJ, Kuroda T, Schaefer E, Oliver-Espinosa OJ, Agne GF, Uberti B, Veiras P, Delph Miller KM, Gialleti R, John E, Toribio RE. Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study. PLoS One 2024;19(11):e0313783.
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