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Home / Equine Research Bank / Equine Vet J / Effect of omeprazole and sucralfate on gastrointestinal inju...
Equine veterinary journal2021; doi: 10.1111/evj.13534

Effect of omeprazole and sucralfate on gastrointestinal injury in a fasting/NSAID model.

Abstract: Equine gastric ulcer syndrome (EGUS) is a common and significant cause of morbidity in horses, with a range of clinical signs, including inappetence, colic and poor performance. Hospitalised horses are exposed to factors that may induce EGUS, including fasting and nonsteroidal anti-inflammatory drug (NSAID) administration, and may be at risk for development of squamous (ESGD) and glandular gastric disease (EGGD). Prophylactic anti-ulcer medication is often prescribed for these patients, but drug selection is complicated by different aetiology and response to treatment of ESGD and EGGD. Objective: To establish the efficacy of sucralfate or omeprazole used prophylactically in horses exposed to a combined feed-fast and NSAID administration EGUS induction protocol. We hypothesised that these drugs would be equally effective for prevention of gastric lesions in the experimental cohort. Methods: Randomised crossover experimental design. Methods: Horses (n = 14) received either omeprazole (1 mg/kg PO q24h) or sucralfate (20 mg/kg PO q8h) while undergoing the feed-fast/NSAID protocol, allowed an 8-week washout period, and then administered the alternate treatment. Serial gastroscopy, ultrasound and haematology documented treatment effects. Results: ESGD and EGGD score increased over time under both treatments. There was a significant effect of treatment on EGGD scores (P < .001), with post-treatment EGGD scores higher for horses receiving sucralfate (median 3; IQR 2.25,3) than omeprazole (1; 1,1). The effect of treatment on ESGD scores just achieved significance (P = .05), with post-treatment ESGD scores higher for sucralfate (4; 3,4) than omeprazole (2; 2,3). Conclusions: This study was performed in healthy horses, and response to treatment may differ in horses with clinical illness. Additional investigation in a larger population may be required to detect significant differences in other clinical parameters. Conclusions: Omeprazole was superior to sucralfate for mitigating gastric lesion severity in healthy horses exposed to a feed-fast/NSAID model.
© 2021 EVJ Ltd.
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Publication Date: 2021-10-31 PubMed ID: 34719063DOI: 10.1111/evj.13534Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a study comparing the efficacy of omeprazole and sucralfate for the prevention of gastric lesions in horses exposed to significant risk factors such as fasting and NSAID administration.

Objective and Hypothesis

The research aimed to understand better the effects of sucralfate and omeprazole when used as preventative medicine in cases where horses undergo a combined fasting/nonsteroidal anti-inflammatory drug (NSAID) protocol which is known to induce Equine Gastric Ulcer Syndrome (EGUS). The hypothesis was that both of these drugs would be equally effective in the prevention of gastric lesions.

Methods

  • The research utilized a randomized crossover experimental design, where horses were randomly assigned to different treatment groups.
  • The researchers administered either omeprazole (1 mg/kg) or sucralfate (20 mg/kg) to a group of 14 horses undergoing the fasting/NSAID protocol.
  • A washout period of 8 weeks was allowed wherein the horse is discharged from the initial treatment and then administered the alternate treatment.
  • Effects of the treatments were observed and documented using serial gastroscopy, ultrasound, and haematology.

Results

  • The study observed that both squamous gastric disease (ESGD) and glandular gastric disease (EGGD) scores showed an increment over time under both treatments.
  • Results revealed a significant effect of treatment on EGGD scores, which were higher in horses receiving sucralfate than those receiving omeprazole.
  • Similar trends were seen on ESGD scores, with a marginally significant difference; the scores higher again for horses receiving sucralfate.

Conclusions

  • It was important to note that this study was conducted on healthy horses, and it was mentioned that treatment responses might differ in clinically ill horses.
  • Researchers also underlined the potential need for further investigation on a larger scale to discern significant differences in other clinical parameters.
  • Based on the study’s results, it was concluded that omeprazole was more effective than sucralfate in mitigating the severity of gastric lesions in healthy horses exposed to the fasting/NSAID model.

Cite This Article

APA
Bishop RC, Kemper AM, Wilkins PA, McCoy AM. (2021). Effect of omeprazole and sucralfate on gastrointestinal injury in a fasting/NSAID model. Equine Vet J. https://doi.org/10.1111/evj.13534

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English

Researcher Affiliations

Bishop, Rebecca C
  • Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois, USA.
Kemper, Ann M
  • Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois, USA.
Wilkins, Pamela A
  • Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois, USA.
McCoy, Annette M
  • Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois, USA.

Grant Funding

  • ILLU-888-949 / U.S. Department of Agriculture

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Citations

This article has been cited 4 times.
  1. Zhou K, Dong Z, Zhou X, Zhai B, Li B, Zhang J, Cheng F. The Prevalence of Gastric Ulcer Syndrome in 395 Horses in Jiangyin City, China, Jiangsu Province. Animals (Basel) 2024 Dec 17;14(24).
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  2. Vokes J, Lovett A, Sykes B. Equine Gastric Ulcer Syndrome: An Update on Current Knowledge. Animals (Basel) 2023 Apr 5;13(7).
    doi: 10.3390/ani13071261pubmed: 37048517google scholar: lookup
  3. Flood J, Stewart AJ. Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses. Animals (Basel) 2022 Oct 26;12(21).
    doi: 10.3390/ani12212939pubmed: 36359062google scholar: lookup
  4. Alshabeeb MA, Alyabsi M, Paras B. Prevalence of exposure to pharmacogenetic drugs by the Saudis treated at the health care centers of the Ministry of National Guard. Saudi Pharm J 2022 Aug;30(8):1181-1192.
    doi: 10.1016/j.jsps.2022.06.013pubmed: 36164570google scholar: lookup
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