Effect of omeprazole paste on gastric acid secretion in horses.
Abstract: In a multicentre trial, 13 cannulated horses were treated orally once daily with a paste that delivered omeprazole at a dose of 4 and 5 mg/kg bwt in a 2-period crossover design to evaluate steady state gastric acid suppression. In each period, basal (unstimulated) and pentagastrin-stimulated gastric output were evaluated at 5-8 h after 5 doses, at 13-16 h after 10 doses, and at 21-24 h after 15 doses. Baseline data for gastric acid secretion were collected once for each horse in the month prior to initiation of omeprazole treatment. The inhibition of gastric acid secretion relative to baseline values, following treatment with omeprazole, were calculated and expressed as per cent. Pharmacokinetic data were also collected in this trial. At 4 mg/kg bwt, the oral paste formulation of omeprazole inhibited both basal and pentagastrin-stimulated gastric acid secretion by 99% at 5-8 h after treatment and by 83% (basal) and 90% (pentagastrin-stimulated) at 21-24 h. Inhibition following the administration of omeprazole at a dose of 5 mg/kg bwt was not significantly greater than when given at 4 mg/kg bwt. The results from this study could possibly lead to the development of an effective and practical antisecretory treatment of ulcer disease in horses.
Publication Date: 2000-03-04 PubMed ID: 10696296DOI: 10.1111/j.2042-3306.1999.tb05171.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
- Multicenter Study
- Randomized Controlled Trial
Summary
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The research conducted a trial on 13 horses to test the effectiveness of an omeprazole paste in inhibiting gastric acid secretion. The results indicated that the paste effectively minimized both basal and stimulated gastric acid secretion significantly, which implies a potential solution for treating ulcer disease in horses.
Research Method
- The study was conducted as a multicentre trial involving 13 horses that were given a treatment of an oral paste that delivered omeprazole at a dose of 4 mg and 5 mg per kg of the horse’s body weight.
- This study was designed in a 2-period crossover, aiming to evaluate the steady state of gastric acid suppression.
- The basal (unstimulated) and pentagastrin-stimulated gastric output after the treatment were observed at different time intervals.
- Baseline data for gastric acid secretion of each horse was collected in the month before the omeprazole treatment began and used for comparison with the data after treatment.
Results
- At the dose of 4 mg/kg body weight, the omeprazole paste succeeded in inhibiting both the basal and pentagastrin-stimulated gastric acid secretion by 99% at 5-8 hours after treatment, and by 83% (basal) and 90% (pentagastrin-stimulated) at 21-24 hours.
- There seemed to be no significant increase in the inhibition of gastric acid secretion when the dosage of omeprazole was increased to 5 mg/kg body weight.
- Pharmacokinetic data, showing how omeprazole is distributed and eliminated in the horse body, was collected throughout the trial.
Implications
- The findings from this research could contribute to the development of new treatments for horses suffering from ulcer diseases, as omeprazole paste effectively minimized gastric acid secretion.
- Further research is needed to narrow down the optimal dosage of omeprazole in achieving higher acid suppression, seeing as an increase from 4 to 5 mg/kg didn’t significantly improve results.
Cite This Article
APA
Daurio CP, Holste JE, Andrews FM, Merritt AM, Blackford JT, Dolz F, Thompson DR.
(2000).
Effect of omeprazole paste on gastric acid secretion in horses.
Equine Vet J Suppl(29), 59-62.
https://doi.org/10.1111/j.2042-3306.1999.tb05171.x Publication
Researcher Affiliations
- Merial Limited, Iselin, New Jersey 08830-3077, USA.
MeSH Terms
- Administration, Oral
- Animals
- Area Under Curve
- Cross-Over Studies
- Enzyme Inhibitors / administration & dosage
- Enzyme Inhibitors / pharmacokinetics
- Enzyme Inhibitors / pharmacology
- Female
- Florida
- Gastric Acid / metabolism
- Gastrointestinal Agents / pharmacology
- Horses / metabolism
- Intubation, Gastrointestinal / veterinary
- Male
- New Jersey
- Ointments
- Omeprazole / administration & dosage
- Omeprazole / pharmacokinetics
- Omeprazole / pharmacology
- Pentagastrin / pharmacology
- Proton Pump Inhibitors
- Tennessee
Citations
This article has been cited 8 times.- Gough S, Hallowell G, Rendle D. Evaluation of the treatment of equine glandular gastric disease with either long-acting-injectable or oral omeprazole. Vet Med Sci 2022 Mar;8(2):561-567.
- Hewetson M, Tallon R. Equine Squamous Gastric Disease: Prevalence, Impact and Management. Vet Med (Auckl) 2021;12:381-399.
- Wise JC, Hughes KJ, Edwards S, Jacobson GA, Narkowicz CK, Raidal SL. Pharmacokinetic and pharmacodynamic effects of 2 registered omeprazole preparations and varying dose rates in horses. J Vet Intern Med 2021 Jan;35(1):620-631.
- Gough S, Hallowell G, Rendle D. A study investigating the treatment of equine squamous gastric disease with long-acting injectable or oral omeprazole. Vet Med Sci 2020 May;6(2):235-241.
- Munsterman AS, Dias Moreira AS, Marqués FJ. Evaluation of a Chinese herbal supplement on equine squamous gastric disease and gastric fluid pH in mares. J Vet Intern Med 2019 Sep;33(5):2280-2285.
- Banse HE, Andrews FM. Equine glandular gastric disease: prevalence, impact and management strategies. Vet Med (Auckl) 2019;10:69-76.
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
- Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003 Jul;44(7):581-5.
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