Effect of postoperative xylazine administration on cardiopulmonary function and recovery quality after isoflurane anesthesia in horses.
Abstract: To evaluate equine cardiopulmonary function and recovery quality after administration of 0.25 or 0.50 mg/kg xylazine intravenously (IV) during recovery. Methods: Randomized, blinded, prospective, clinical study. Methods: Horses (n = 20). Methods: During recovery after 3 hours of isoflurane anesthesia for arthroscopic surgery, horses were administered either 0.25 mg/kg (G25, n = 10) or 0.50 mg/kg (G50, n = 10) xylazine intravenously. Vital signs and arterial blood samples were obtained during recovery before sedation (baseline), 5, 10, 20, 30, and 45 minutes after xylazine and 30 minutes after standing. The quality of recovery scores ranged from 10 to 72 (10 = best, 72 = worst). Results: G25 horses recovered faster (mean ± SD, 33 ± 5 min) than G50 horses (50 ± 7 min, P < .0001). Mean maximal decrease in arterial oxygen tension was 55 ± 11 mmHg in G25 (at 10 minutes; P < .05) and 54 ± 7 mmHg in G50 (at 20 minutes; P < .01). G25 group had a total recovery score (23 [range 18-29]) and number of attempts to stand (4 ± 2) greater than the G50 group (18 [10-23] and 1 ± 1, respectively; P < .001). Conclusions: Both doses of xylazine promoted a moderate and transient hypoxemia during recovery; however, the 0.5 mg/kg dose produced a longer and improved quality of recovery from anesthesia.
© Copyright 2013 by The American College of Veterinary Surgeons.
Publication Date: 2013-09-03 PubMed ID: 24033770DOI: 10.1111/j.1532-950X.2013.12050.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The study explores the impact of administering different doses of the drug xylazine on the heart and lung functions of horses recovering from isoflurane anesthesia after arthroscopic surgery. The research found that lower doses result in quicker recovery times, though the quality of recovery is better when higher doses are administered.
Methodology
- The research was set up as a randomized, blinded, prospective, clinical study involving 20 horses.
- Following 3 hours of isoflurane anesthesia for arthroscopic surgery, the horses were split into two groups, each receiving different doses of xylazine intravenously during their recovery. Ten horses were given 0.25 mg/kg of xylazine (G25), while the remaining ten horses received 0.50 mg/kg of xylazine (G50).
- Vital signs and arterial blood samples were collected at several intervals during the recovery and post-sedation period, these being: before sedation (baseline), 5, 10, 20, 30, and 45 minutes after xylazine administration and another 30 minutes after standing.
Findings
- Horses in the G25 group were found to recover faster (mean of 33 minutes) than those in the G50 group (mean of 50 minutes). However, the recovery scores – a higher score indicating slower recovery – were better in the G50 group.
- Both groups experienced a significant decrease in arterial oxygen tension after receiving xylazine, indicating somewhat similar levels of hypoxemia (low oxygen level in the blood).
- The G25 group exhibited more attempts to stand but had a higher total recovery score, suggesting recovery quality was poorer than the G50 group.
Conclusions
- The study concluded that both doses of xylazine cause a moderate and transient occurrence of hypoxemia during the recovery period.
- Despite the longer recovery time, the higher dosage (0.50 mg/kg) of xylazine resulted in an improved quality of recovery from anesthesia compared to the lower dosage (0.25 mg/kg).
Cite This Article
APA
Ida KK, Fantoni DT, Ibiapina BT, Souto MT, Zoppa AL, Silva LC, Ambrósio AM.
(2013).
Effect of postoperative xylazine administration on cardiopulmonary function and recovery quality after isoflurane anesthesia in horses.
Vet Surg, 42(7), 877-884.
https://doi.org/10.1111/j.1532-950X.2013.12050.x Publication
Researcher Affiliations
- Laboratório de Investigação Médica LIM-08, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, Brazil.
MeSH Terms
- Analgesics / pharmacology
- Anesthesia Recovery Period
- Anesthesia, Inhalation / veterinary
- Anesthetics, Inhalation / pharmacology
- Animals
- Arthroscopy / adverse effects
- Arthroscopy / veterinary
- Bicarbonates / blood
- Blood Chemical Analysis / veterinary
- Blood Glucose
- Body Temperature
- Carbon Dioxide / blood
- Heart Rate / drug effects
- Horses
- Hydrogen-Ion Concentration
- Isoflurane / pharmacology
- Oxygen / blood
- Pain, Postoperative / prevention & control
- Pain, Postoperative / veterinary
- Xylazine / pharmacology
Citations
This article has been cited 2 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
- Aoki M, Wakuno A, Kushiro A, Mae N, Kakizaki M, Nagata SI, Ohta M. Evaluation of total intravenous anesthesia with propofol-guaifenesin-medetomidine and alfaxalone-guaifenesin-medetomidine in Thoroughbred horses undergoing castration.. J Vet Med Sci 2017 Dec 22;79(12):2011-2018.
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