Effect of ranitidine on gastric acid secretion in young male horses.
Abstract: Gastric cannulas were placed surgically in 5 young male horses. After a 2-week recovery period, horses were studied once a week. Horses were fasted for 24 hours, and gastric fluid output was collected for 5 continuous hours. Volumes were recorded every 15 minutes, and pH and hydrogen ion concentration were determined in an aliquot from each period. In 10 basal experiments, using 5 horses, volume, pH, and hydrogen ion concentration were continuously variable. Mean acid output was 45.1 +/- 2.02 microEq/15 min/kg (mean +/- SEM). In 6 experiments, using 3 horses, 0.5 mg of ranitidine/kg of body weight, given as an IV bolus after a 1-hour basal collection, significantly (P less than 0.02) inhibited hourly total acid output for 4 hours, but did not significantly change pH. The cannulation technique was done without complications, and horses tolerated the cannula for several months. Seemingly, the horse has a continuously variable gastric acid secretion, and histamine type-2 receptors have a role in this process.
Publication Date: 1987-10-01 PubMed ID: 3674562
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
Summary
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The research study is basically investigating the effects of a drug called ranitidine on the production of stomach acid in young male horses.
Methodology
- The researchers started by surgically inserting gastric cannulas into five young male horses. A gastric cannula is a tube inserted into the stomach to collect gastric fluid.
- After allowing the horses a two-week recovery period, the horses were studied once a week.
- Prior to the study, the horses were fasted for 24 hours. Gastric fluid output was then collected from the horses for a continuous period of 5 hours.
- The fluid volumes recorded came from 15-minute intervals, with pH and hydrogen ion concentration determined from each collection period.
Results
- In ten basal experiments using the five horses, the researchers found that the volume, pH, and hydrogen ion concentration were continuously variable. This basically means that these factors were constantly changing and not stable.
- The average acid output was calculated to be 45.1 +/- 2.02 microEq/15 min/kg (mean +/- SEM).
- In six additional experiments using three horses, the researchers administered an intravenous bolus of 0.5 mg of ranitidine per kg of body weight. This was given after a 1-hour basal collection.
- The administration of ranitidine significantly inhibited the total acid output for 4 hours (P less than 0.02), but it did not significantly change the pH of the gastric fluid.
- The technique used to cannulate the horses was executed without complications, and the horses were able to tolerate the cannula for several months.
Conclusion
- From the results of the study, the researchers concluded that the horse has a continuously variable gastric acid secretion. This means that the amount of stomach acid a horse produces can vary over time.
- Furthermore, the study showed that ranitidine was effective in reducing the total output of stomach acid in the horses, suggesting that histamine type-2 receptors play a role in this process. Histamine type-2 receptors are found in the stomach lining and are activated to release stomach acid. Ranitidine is a type of drug known as an H2-receptor antagonist, meaning it works by blocking these receptors and reducing the amount of stomach acid produced.
Cite This Article
APA
Campbell-Thompson ML, Merritt AM.
(1987).
Effect of ranitidine on gastric acid secretion in young male horses.
Am J Vet Res, 48(10), 1511-1515.
Publication
Researcher Affiliations
- Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
MeSH Terms
- Animals
- Catheterization / methods
- Catheterization / veterinary
- Gastric Acid / metabolism
- Horses / physiology
- Male
- Ranitidine / pharmacology
- Stomach / drug effects
- Stomach / physiology
Citations
This article has been cited 4 times.- Hewetson M, Tallon R. Equine Squamous Gastric Disease: Prevalence, Impact and Management.. Vet Med (Auckl) 2021;12:381-399.
- Orsini JA, Spencer PA. Effects of a histamine type 2 receptor antagonist, BMY-26539-01, on equine gastric acid secretion.. Can J Vet Res 2001 Jan;65(1):55-9.
- Murray MJ. Equine model of inducing ulceration in alimentary squamous epithelial mucosa.. Dig Dis Sci 1994 Dec;39(12):2530-5.
- Geor RJ, Petrie L, Papich MG, Rousseaux C. The protective effects of sucralfate and ranitidine in foals experimentally intoxicated with phenylbutazone.. Can J Vet Res 1989 Apr;53(2):231-8.
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