Effect of ranitidine on healing of experimentally induced gastric ulcers in ponies.
Abstract: Thirty young ponies were examined endoscopically for evidence of gastric ulceration. Seven ponies had noninduced gastric ulcers present at the initial examination and were eliminated from the study. In an attempt to induce gastric ulcers experimentally, flunixin meglumine (1.1 mg/kg of body weight, IM, q 8 h) was administered for 7 days to the 23 ponies with endoscopically normal gastric mucosa. During the 7 days of flunixin administration, 11 ponies developed gastric ulcers that were appropriate for study. The 11 ponies were randomly allotted to 2 groups. Group-A (n = 5) and group-B (n = 6) ponies received ranitidine (4.4 mg/kg, PO, q 8 h) and corn syrup, respectively, until ulcers healed or for a maximum of 40 days. General anesthesia was induced every 3 to 5 days for visual evaluation of ulcer healing by use of a video endoscope. The earliest complete healing of gastric lesions observed in a corn syrup-treated pony was at 17 days. At 40 days, 3 of 5 and 3 of 6 ponies of the ranitidine and corn syrup-treated groups, respectively, had healed ulcers. Results of this study indicate that: noninduced gastric ulcers may be common in young ponies, flunixin meglumine may be effective in inducing gastric ulcers for gastric healing studies in young ponies, and ranitidine (4.4 mg/kg, q 8 h) is not significantly effective in accelerating healing of experimentally induced gastric ulcers in ponies under conditions of this study.
Publication Date: 1993-07-01 PubMed ID: 8368605
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research is about studying the effects of ranitidine on healing gastric ulcers in ponies. It was found that ranitidine is not significantly effective in accelerating the healing process of experimentally induced gastric ulcers in ponies.
Participants and Initial Findings
- The study involved thirty young ponies where they were examined for signs of gastric ulceration using an endoscope.
- Of these, seven ponies had pre-existing non-induced gastric ulcers and were, therefore, excluded from the study, leaving only 23 ponies.
Ulcer Induction
- To induce gastric ulcers artificially in these healthy ponies, flunixin meglumine was administered at a concentration of 1.1 mg/kg of body weight via intramuscular injections every eight hours for a week.
- At the end of this administration period, eleven ponies developed gastric ulcers suitable for the study and were selected further.
Treatment Groups
- These 11 ponies were randomly divided into two groups, Groups A and B, comprising of five and six ponies respectively.
- Ponies in Group A were given oral ranitidine at a dose of 4.4 mg/kg every eight hours, while those in Group B were administered with corn syrup for the same period, serving as a control group. This continued until the ulcers healed or for a maximum of 40 days.
Observation of Healing
- Anesthesia was induced in the ponies every three to five days to enable visual evaluation of the healing progress of the ulcers using a video endoscope.
- The earliest occurrence of complete healing in a pony from the corn syrup treated group was noted at 17 days.
- After the stipulated 40 days, three out of five ponies from the ranitidine group, and three out of six ponies from the corn syrup group had healed ulcers.
Conclusions
- The researchers concluded that gastric ulcers may occur frequently in young ponies without being artificially induced.
- Flunixin meglumine was found to be effective in inducing gastric ulcers in these ponies, making it useful for conducting gastric healing studies.
- However, the most significant finding was that ranitidine did not play a significant role in accelerating the healing of the artificially induced ulcers in the ponies under the conditions of this study.
Cite This Article
APA
MacAllister CG, Sangiah S.
(1993).
Effect of ranitidine on healing of experimentally induced gastric ulcers in ponies.
Am J Vet Res, 54(7), 1103-1107.
Publication
Researcher Affiliations
- Department of Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Clonixin / analogs & derivatives
- Horse Diseases
- Horses
- Ranitidine / therapeutic use
- Stomach Ulcer / chemically induced
- Stomach Ulcer / drug therapy
- Stomach Ulcer / veterinary
- Time Factors
- Wound Healing / drug effects
Citations
This article has been cited 2 times.- Albanese V, Munsterman A, Klohnen A. Prevalence of Gastric Ulceration in Horses with Enterolithiasis Compared with Horses with Simple Large Intestinal Obstruction. Vet Sci 2022 Oct 25;9(11).
- Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003 Jul;44(7):581-5.
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