Effect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horses.
Abstract: Sea buckthorn berries (Hippophae rhamnoides) are rich in vitamin C and E, carotenoids, flavonoids, fatty acids, plant sterols, lignans, and minerals. A feed supplement containing sea buckthorn berries might have efficacy in treatment and prevention of gastric ulcers in horses. Objective: To test the efficacy of a commercially available formulation of sea buckthorn berries and pulp (SeaBuck SBT Gastro-Plus) for treatment and prevention of gastric ulcers in stall-confined horses. Methods: Eight Thoroughbred and Thoroughbred-cross horses (3-10 years of age, 5 geldings and 3 mares, 380-600 kg body weight). Methods: This study was a 2-period crossover in which all horses received no treatment (untreated controls; n = 8) and treatment (SeaBuckSBT Gastro-Plus, 4 ounces [35.6 g berries and pulp], twice daily; n = 8) mixed with a pelleted complete feed (18% crude fiber; 9% starch; 14% crude protein). Horses were treated for 4 weeks followed by a 1-week (d28-d35) alternating feed-deprivation period to induce or worsen existing ulcers. Gastroscopic examinations were performed on days 0, 28, and 35. Gastric juice pH was measured and gastric ulcer number and severity scores were assigned by a masked investigator. Results: Mean nonglandular gastric ulcer scores significantly (P < .05) increased in all horses after day 28, as a result of intermittent feed deprivation. Mean nonglandular gastric ulcer number (P = .84) and severity (P = .51) were not significantly different between SBT-treated and untreated control horses. However, mean glandular ulcer number (P = .02) and glandular ulcer severity (P = .02) were significantly lower in the SBT-treated horses compared with the untreated control at week 5. Conclusions: SeaBuck SBT Gastro-Plus liquid fed to horses did not show efficacy in treatment or prevention of naturally occurring nonglandular ulcers in horses; however, glandular ulcer scores were significantly lower in SBT-treated horses after feed deprivation. Thus, SBT might have efficacy in prevention of glandular ulcers in horses housed in stalls and undergoing intermittent feeding.
Copyright © 2012 by the American College of Veterinary Internal Medicine.
Publication Date: 2012-07-28 PubMed ID: 22845737DOI: 10.1111/j.1939-1676.2012.00975.xGoogle Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The research study concluded that sea buckthorn berries and pulp (in a product known as SeaBuck SBT Gastro-Plus liquid) may not effectively prevent or treat non-glandular ulcers in horses. However, it showed potential in reducing the number and severity of glandular ulcers, especially in horses in stalls and experiencing intermittent feeding.
Methodology
- The experiment was conducted on eight thoroughbred and thoroughbred-cross horses ranging between 3 to 10 years of age and weighing between 380-600 kg.
- The study adopted a 2-period crossover method where all horses formed part of the untreated control group (n=8) and the treatment group (n=8).
- The horses in the treatment group were given SeaBuck SBT Gastro-Plus, which was mixed with their standard feed. This treatment regimen lasted for 4 weeks.
- After the 4 weeks of treatment, there followed a week-long (from day 28 to day 35) period of alternating feed deprivation to trigger or intensify any existing ulcers.
- Gastroscopic examinations were carried out on the start day, day 28, and day 35.
- The severity and number of gastric ulcers were determined by a masked investigator, who also measured the horses’ gastric juice pH.
Results
- The average nonglandular gastric ulcer scores of all horses showed a significant increase by day 28. This was attributed to the intermittent feed deprivation imposed on the horses.
- No significant difference was observed in terms of the number and severity of nonglandular ulcers between the horses who received SBT treatment and the untreated control horses.
- However, the average number and severity of glandular ulcers were significantly lower in the SBT-treated horses versus the untreated ones when measured at week 5.
Conclusion
- The conclusion based on the outcome is that SeaBuck SBT Gastro-Plus liquid did not significantly affect the treatment or prevention of nonglandular ulcers in horses.
- Yet, the treatment was found to reduce the severity and number of glandular ulcers significantly, specifically in horses housed in stalls and undergoing intermittent feeding.
- This suggests that SBT may potentially help prevent glandular ulcers in such scenarios.
Cite This Article
APA
Huff NK, Auer AD, Garza F, Keowen ML, Kearney MT, McMullin RB, Andrews FM.
(2012).
Effect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horses.
J Vet Intern Med, 26(5), 1186-1191.
https://doi.org/10.1111/j.1939-1676.2012.00975.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Equine Health Studies Program, Louisiana State University, Baton Rouge, LA 70803, USA.
MeSH Terms
- Animals
- Cross-Over Studies
- Female
- Fruit
- Gastric Juice / metabolism
- Gastroscopy / veterinary
- Hippophae
- Horse Diseases / drug therapy
- Horse Diseases / metabolism
- Horse Diseases / pathology
- Horses
- Hydrogen-Ion Concentration
- Least-Squares Analysis
- Male
- Phytotherapy / veterinary
- Seasons
- Stomach Ulcer / drug therapy
- Stomach Ulcer / metabolism
- Stomach Ulcer / pathology
- Stomach Ulcer / veterinary
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