Effect of sodium methyl arsinate and imidocarb dipropionate antiprotozoal drugs on the pharmacokinetic of gentamicin in equines.

The research article investigates how antiprotozoal drugs, specifically sodium methyl arsinate and imidocarb dipropionate, affect the absorption, distribution, and elimination of the antibiotic gentamicin in horses.

Research Methodology

• The researchers conducted their experiment on two groups of horses. One group was given an intramuscular injection of gentamicin sulphate alone, while the others were premedicated with either sodium methyl arsinate or imidocarb dipropionate before receiving the gentamicin sulphate.
• Gentamicin sulphate was administered at a dose of 3.4 mg/kg of body weight (bwt), while sodium methyl arsinate and imidocarb dipropionate were given at doses of 2 mg/kg bwt and 4.8 mg/kg bwt respectively.
• The researchers then observed the pharmacokinetic behavior of gentamicin in the two groups of horses, with a focus on its peak serum concentration and elimination half-life.

Research Findings

• Differences in the pharmacokinetics of gentamicin were observed between the horses premedicated with antiprotozoal drugs and those that received the antibiotic alone.
• The peak serum concentration of gentamicin was reached faster in horses premedicated with either sodium methyl arsinate or imidocarb dipropionate, compared to non-medicated horses.
• Furthermore, gentamicin was eliminated more quickly from the bodies of horses premedicated with the antiprotozoal drugs, hence indicating a faster gentamicin elimination half-life.
• Additionally, the interval between doses, or interdose interval, needed to maintain a therapeutic level of gentamicin was found to be shorter in premedicated animals compared to those that weren’t premedicated.

Research Conclusion

• The study confirmed that the pharmacokinetics of gentamicin are impacted when horses are also being treated with the antiprotozoal drugs sodium methyl arsinate and imidocarb dipropionate.
• These findings imply that when planning a combined therapy involving these drugs, dosage adjustments may be needed to account for changes in the absorption, distribution, and elimination of gentamicin.