Effect of sucralfate on total carbon dioxide concentration in horses subjected to a simulated race test.
Abstract: The purpose of this study was to test the hypothesis that sucralfate, a gastric ulcer medication, would alter plasma concentrations of total carbon dioxide (tCO2), lactate (LA), sodium (Na+), potassium (K+), chloride (Cl-) and total protein (TP), as well as calculated plasma strong ion difference (SID) and packed cell volume (PCV) in horses subjected to a simulated race test (SRT). Six unfit Standardbred mares (approximately 520 kg, 9-18 years) were used in a randomized crossover design with the investigators blinded to the treatment given. The horses were assigned to either a control (40-50 mL apple sauce administered orally (PO)) or a sucralfate (20 mg/kg bodyweight dissolved in 40-50 mL apple sauce administered PO) group. Each horse completed a series of SRTs during which blood samples were taken via jugular venipuncture at five sampling intervals (prior to receiving treatment, prior to SRT, immediately following exercise, and at 60 and 90 min post-SRT). During the SRTs, each horse ran on a treadmill fixed on a 6% grade for 2 min at a warm-up speed (4 m/s) and then for 2 min at a velocity predetermined to produce VO2max. Each horse then walked at 4 m/s for 2 min to complete the SRT. Plasma tCO2, electrolytes, LA, and blood PCV and TP were analysed at all intervals. No differences (P>0.05) were detected between control and sucralfate for any of the measured variables. There were differences (P<0.05) in tCO2, SID, PCV, TP, LA and electrolyte concentrations relative to sampling time. However, these differences were attributable to the physiological pressures associated with acute exercise and were not an effect of the medication. It was concluded that sucralfate did not alter plasma tCO2 concentration in this study.
Copyright (c) 2008 Elsevier Ltd. All rights reserved.
Publication Date: 2008-10-23 PubMed ID: 18951051DOI: 10.1016/j.tvjl.2008.09.003Google Scholar: Lookup
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- Journal Article
Summary
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The research studied the effect of a gastric ulcer medication, sucralfate, on the total carbon dioxide (tCO2) concentration and other parameters in the blood of horses after a simulated race test. The results showed that sucralfate did not significantly change any of these variables.
Research Objectives and Design
- The study was conducted to test the effect of sucralfate, a drug commonly used to treat gastric ulcers, on the tCO2, lactate, sodium, potassium, chloride, and total protein concentrations in horse plasma. It also aimed to study its effect on the plasma strong ion difference (SID) and packed cell volume (PCV).
- A total of six unfit Standardbred mares (aged 9-18 years and weighing approximately 520 kg) were used for the research. The study employed a crossover design which means each horse was used in both the control and treatment groups at different times.
- The researchers carried out the study while being blinded to the group to which the horses were assigned to eliminate bias.
Procedure and Results
- The horses were randomly assigned to two groups: the control group received 40-50 mL of apple sauce, and the treatment group received sucralfate (20 mg/kg body weight dissolved in apple sauce).
- Each horse underwent a series of simulated race tests during which blood samples were obtained at five different intervals. These times included before treatment, before the race test, immediately after exercise, 60 minutes post-race, and 90 minutes post-race.
- These samples were analysed for electrolyte concentrations, lactate levels, plasma tCO2, and blood PCV and total protein.
- The research found no significant difference (P>0.05) between the control group and the sucralfate group for all the tested variables. There were variations in some values over the time but these were tied to exertion from exercise rather than the medication.
Conclusion
- The study concluded that sucralfate does not change plasma tCO2 concentration in horses. This suggests that the medication has no significant impact on the blood chemistry of horses after physical exertion.
Cite This Article
APA
Caltabilota TJ, Milizio JG, Malone S, Kenney JD, McKeever KH.
(2008).
Effect of sucralfate on total carbon dioxide concentration in horses subjected to a simulated race test.
Vet J, 183(2), 191-195.
https://doi.org/10.1016/j.tvjl.2008.09.003 Publication
Researcher Affiliations
- Equine Science Center, Department of Animal Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
MeSH Terms
- Acid-Base Equilibrium / drug effects
- Acid-Base Equilibrium / physiology
- Animals
- Anti-Ulcer Agents / pharmacology
- Anti-Ulcer Agents / therapeutic use
- Carbon Dioxide / blood
- Carbon Dioxide / metabolism
- Cross-Over Studies
- Exercise Test / veterinary
- Female
- Horse Diseases / drug therapy
- Horses
- Oxygen Consumption / drug effects
- Oxygen Consumption / physiology
- Physical Conditioning, Animal / physiology
- Random Allocation
- Stomach Ulcer / drug therapy
- Stomach Ulcer / veterinary
- Sucralfate / pharmacology
- Sucralfate / therapeutic use
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