Effect of Topical 1% Cyclopentolate Hydrochloride on Tear Production, Intraocular Pressure, and Pupil Size in Healthy Turkman Horses.
Abstract: This study was performed to evaluate the effect of topical 1% cyclopentolate hydrochloride on tear production (STT), intraocular pressure (IOP), and vertical pupil diameter (VPD) in healthy Turkman horses. Forty eyes of 20 clinically normal horses were used for this study, which were randomly assigned to two groups. Before instillation of 1% cyclopentolate, the baseline STT, IOP, and VPD of each group were recorded. Then, one drop of cyclopentolate was instilled randomly into one eye of each animal, and the contralateral eye served as control. Measurements were repeated at 20 minutes, 60 minutes, 90 minutes, 120 minutes, 12 hours, and 24 hours, and every 24 hours up to 120 hours post drug instillation in all animals. There was no significant effect on STT over the time course measured in both the treated and untreated eyes of the treatment groups after unilateral instillation of 1% cyclopentolate when compared to baseline values. A significant increase in the IOP was observed after 20 minutes, which persisted for more than 90 minutes; then, the IOP insignificantly decreased below the baseline values after 120 minutes. Maximum VPD was recognized at 12 hours post instillation in treated eyes (15.8 ± 2.3 mm), which was significantly different in comparison to the baseline (P = .07). Cyclopentolate could be considered as a long term and potent cycloplegic drug in horses when taking into account the possible side effect of atropine.
Copyright © 2019 Elsevier Inc. All rights reserved.
Publication Date: 2019-01-29 PubMed ID: 31002088DOI: 10.1016/j.jevs.2019.01.002Google Scholar: Lookup
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- Journal Article
Summary
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The study investigates the impacts of using a 1% solution of cyclopentolate hydrochloride eye drops on healthy Turkman horses, focusing on changes to tear production, intraocular pressure, and pupil size.
Research Setup
- The research was conducted using 40 eyes from 20 physically normal Turkman horses.
- These were divided into two sets randomly.
- Before applying the 1% cyclopentolate solution, the baseline measurements for tear production, intraocular pressure, and vertical pupil diameter were recorded in each group.
- In each animal, cyclopentolate was instilled into one eye, while the other eye acted as a control group.
- Measurements were recorded again at different time periods ranging from 20 minutes to 120 hours post-application.
Findings
- Tear production, measured by Schirmer Tear Test (STT), remained unaffected over time in both cyclopentolate-treated and untreated eyes when compared to the baseline measurements.
- Intraocular pressure (IOP), however, showed a significant increase 20 minutes after application. This heightened pressure lasted for more than 90 minutes. Post 120 minutes, the IOP dropped below the baseline, though not significantly.
- Changes in vertical pupil diameter (VPD) were most noticeable 12 hours after application of the drug, with a noteworthy size increase to 15.8 ± 2.3 mm in comparison to the original measurements (P = .07).
Conclusion
- Giving the outcomes, Cyclopentolate was identified as a potent long-term cycloplegic (pupil-dilating) drug for horses. It is suggested as a possible alternative to atropine, which may cause side effects.
- However, due consideration should be given to its effect on intraocular pressure before administration.
Cite This Article
APA
Ansari Mood M, Rajaei SM, Faghihi H, Ghiadi A.
(2019).
Effect of Topical 1% Cyclopentolate Hydrochloride on Tear Production, Intraocular Pressure, and Pupil Size in Healthy Turkman Horses.
J Equine Vet Sci, 75, 25-29.
https://doi.org/10.1016/j.jevs.2019.01.002 Publication
Researcher Affiliations
- Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran.
- Ophthalmology Section, Negah Veterinary Centre, Tehran, Iran. Electronic address: Mehdi_13r@hotmail.com.
- Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran; Ophthalmology Section, Negah Veterinary Centre, Tehran, Iran.
- Member of Turkmen Horse Breeding & Consulting Co. (THBC), Jargalan, North Khorasan Province, Iran.
MeSH Terms
- Animals
- Cyclopentolate
- Horses
- Intraocular Pressure
- Mydriatics
- Pupil
- Tonometry, Ocular
Citations
This article has been cited 1 times.- Kovalcuka L, Nikolajenko M. Changes in intraocular pressure, horizontal pupil diameter, and tear production during the use of topical 1% cyclopentolate in cats and rabbits.. Open Vet J 2020 Apr;10(1):59-67.
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