Effect of topical ophthalmic latanoprost on intraocular pressure in normal horses.

This study investigates the impact of a daily dose of latanoprost ocular solution over a five-day period on intraocular pressure and pupillary diameter in horses, concluding that this therapy had no significant effect on normal horse eyes in comparison to a control group.

Research Objectives

• The study aims to understand the effects of latanoprost ophthalmic solution on intraocular pressure and pupillary diameter in horses.
• The investigation involved conducting two distinct studies, with eight horses participating in each.
• A side-by-side comparison was created by applying the latanoprost ophthalmic solution to one eye of each horse, while the other eye received a sterile eyewash control solution.

Methodology and Measurements

• The treatment with latanoprost ophthalmic solution was carried out once daily over the course of five days.
• Both intraocular pressure and the diameter of the pupil were recorded for five consecutive days following the treatment.

Results

• The research found that latanoprost had no significant impact on either intraocular pressure or pupillary diameter in normal horse eyes, compared to the control group.
• In an interesting ancillary outcome, it was observed that the use of an eyelid nerve block resulted in a noticeable decrease in intraocular pressure.

Conclusions

• Overall, the use of latanoprost ophthalmic solution as a daily treatment over a five-day period exhibited no significant effect on either the intraocular pressure or the diameter of the pupil in horses.
• This outcome is contrasted by the apparent lowering of intraocular pressure observed following the placement of an eyelid nerve block.