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Home / Equine Research Bank / Can Vet J / Effectiveness of oxibendazole against benzimidazole-resistan...
The Canadian veterinary journal = La revue veterinaire canadienne1989; 30(8); 663-665;

Effectiveness of oxibendazole against benzimidazole-resistant strongyles in horses.

Abstract: Twenty-eight horses with a residual burden of strongyle eggs in the faces after treatment with mebendazole (MBZ) paste were treated with a suspension of either MBZ or oxibendazole (OBZ). Fecal samples were collected before and 14 days after these treatments. The number of strongyle eggs/g (epg) of feces for each horse was estimated using the Cornell-McMaster dilution and the Cornell-Wisconsin double centrifugation procedures. The epg for each horse was transformed using log (x + 1) and in an analysis of variance of the reduction in egg count for each horse on the logarithmic scale, there was a highly significant difference between the treatments. The mean epg was increased in the MBZ-treated horses and reduced in the OBZ-treated horses, but the reduction was only by 82% with an upper confidence limit of 89%. Subsequently, the horses were retreated with MBZ and OBZ suspensions without significant reduction in the mean epg for OBZ-treated horses.
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Publication Date: 1989-08-01 PubMed ID: 17423395PubMed Central: PMC1681156
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the effectiveness of oxibendazole in treating horses infected by strongyles, which have shown resistance to mebendazole.

Understanding the experimental design

  • The researchers started with 28 horses that still show signs of strongyle infection after being treated with mebendazole (MBZ).
  • These horses were then treated either with a new dose of MBZ or a new drug, oxibendazole (OBZ).
  • Fecal samples were collected from the horses before and 14 days after the treatments. The fecal samples were analyzed to estimate the number of strongyle eggs per gram (epg) of feces.
  • The researchers used two statistical procedures called the Cornell-McMaster dilution and the Cornell-Wisconsin double centrifugation to analyze the data collected.

Observations and findings

  • The results showed a significant difference in the effectiveness of the two treatments. MBZ treatment resulted in an increase in epg while OBZ treatment led to a decrease.
  • The reduction in epg in OBZ-treated horses was about 82%, with a confidence limit of 89%. This suggests that OBZ was effective in decreasing the strongyle burden in horses.

Subsequent treatment and conclusion

  • After observing these results, the researchers conducted a second round of treatments with MBZ and OBZ.
  • No significant reduction in epg was found in the OBZ-treated horses. This might imply that while OBZ initially showed effectiveness against the strongyles, repeated use might not result in further reduction of the infection.

In conclusion, the research found that oxibendazole shows potential effectiveness in treating horses infected by strongyles that are resistant to mebendazole. Further research may be needed to determine the long-term effectiveness and the best dosage or frequency of OBZ treatment.

Cite This Article

APA
Slocombe JO, Cote JF, McMillan I. (1989). Effectiveness of oxibendazole against benzimidazole-resistant strongyles in horses. Can Vet J, 30(8), 663-665.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 30
Issue: 8
Pages: 663-665

Researcher Affiliations

Slocombe, J O
    Cote, J F
      McMillan, I

        References

        This article includes 16 references
        1. Drudge JH, Lyons ET, Tolliver SC, Kubis JE. Clinical trials with fenbendazole and oxibendazole for Strongyloides westeri infection in foals.. Am J Vet Res 1981 Mar;42(3):526-7.
          pubmed: 7023296
        2. Theodorides VJ, Nawalinski T, Chimes N, Weideman C, Free SM. Anthelmintic efficacy of oxibendazole in ponies: comparison of methods.. Am J Vet Res 1982 May;43(5):892-4.
          pubmed: 7091856
        3. Egwang TG, Slocombe JO. Evaluation of the Cornell-Wisconsin centrifugal flotation technique for recovering trichostrongylid eggs from bovine feces.. Can J Comp Med 1982 Apr;46(2):133-7.
          pubmed: 7093809
        4. Webster JH, Baird JD, Gunawan M, Martin IC, Kelly JD. Resistance to benzimidazole anthelmintics in equine strongyles. 2. Evidence of side-resistance, and susceptibility of benzimidazole-resistant strongyles to non-benzimidazole compounds.. Aust Vet J 1981 Apr;57(4):172-81.
          pubmed: 7271606doi: 10.1111/j.1751-0813.1981.tb00504.xgoogle scholar: lookup
        5. Wescott RB. Anthelmintics and drug resistance.. Vet Clin North Am Equine Pract 1986 Aug;2(2):367-80.
          pubmed: 3527378doi: 10.1016/s0749-0739(17)30722-8google scholar: lookup
        6. Drudge JH, Lyons ET, Tolliver SC, Swerczek TW. Use of oxibendazole for control of cambendazole-resistant small strongyles in a band of ponies: a six-year study.. Am J Vet Res 1985 Dec;46(12):2507-11.
          pubmed: 4083584
        7. Drudge JH, Lyons ET, Tolliver SC. Critical and clinical test evaluations of mebendazole against internal parasites of the horse.. Am J Vet Res 1974 Nov;35(11):1409-12.
          pubmed: 4429242
        8. Round MC, Simpson DJ, Haselden CS, GlendinningES, Baskerville RE. Horse strongyles' tolerance to anthelmintics.. Vet Rec 1974 Nov 30;95(22):517-8.
          pubmed: 4462733doi: 10.1136/vr.95.22.517google scholar: lookup
        9. Drudge JH, Lyons ET, Tolliver SC, Kubis JE. Clinical trials of oxibendazole for control of equine internal parasites including benzimidazole-resistant small strongyles.. Mod Vet Pract 1981 Sep;62(9):679-82.
          pubmed: 7022161
        10. Drudge JH, Lyons ET, Tolliver SC, Kubis JE. Critical tests and clinical trials on oxibendazole in horses with special reference to removal of Parascaris equorum.. Am J Vet Res 1979 Jun;40(6):758-61.
          pubmed: 475125
        11. Drudge JH, Lyons ET, Tolliver SC. Benzimidazole resistance of equine stronygles--critical tests of six compounds against population B.. Am J Vet Res 1979 Apr;40(4):590-4.
          pubmed: 517836
        12. Barger IA, Lisle KA. Benzimidazole resistance in small strongyles of horses.. Aust Vet J 1979 Dec;55(12):594-5.
          pubmed: 539943doi: 10.1111/j.1751-0813.1979.tb07056.xgoogle scholar: lookup
        13. Nawalinski T, Theodorides VJ. Efficacy of three forms of oxibendazole against gastrointestinal parasites of ponies.. Vet Med Small Anim Clin 1977 Jan;72(1):96-101.
          pubmed: 584106
        14. Slocombe JO, Cote JF. Small strongyles of horses with cross resistance to benzimidazole anthelmintics and susceptibility to unrelated compounds.. Can Vet J 1977 Aug;18(8):212-7.
          pubmed: 890649
        15. Kates KC, Colglazier ML, Enzie FD. Oxibendazole: critical anthelmintic trials in equids.. Vet Rec 1975 Dec 6;97(23):442-4.
          pubmed: 1216434
        16. Nawalinski T, Theodorides VJ. Critical tests with oxibendazole against gastrointestinal parasites of ponies.. Am J Vet Res 1976 Apr;37(4):469-71.
          pubmed: 1267243

        Citations

        This article has been cited 2 times.
        1. Elsener J, Villeneuve A. Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.. Can Vet J 2009 May;50(5):486-90.
          pubmed: 19436633
        2. Slocombe JO, Coté JF, de Gannes RV. The persistence of benzimidazole-resistant cyathostomes on horse farms in Ontario over 10 years and the effectiveness of ivermectin and moxidectin against these resistant strains.. Can Vet J 2008 Jan;49(1):56-60.
          pubmed: 18320979
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