FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Equine Vet J / Effects of alpha-2 adrenoceptor agonists during recovery fro...
Equine veterinary journal2003; 35(2); 170-175; doi: 10.2746/042516403776114117

Effects of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses.

Abstract: Recovery from inhalant anaesthesia in the horse is a critical and difficult period to manage; however, several factors could help to obtain a calm recovery period including choice of anaesthetic and analgesic procedure used and the conditions under which anaesthetic maintenance and recovery occur. Objective: The objective of this study was to evaluate and compare the quality of recovery in horses administered saline, xylazine, detomidine or romifidine during recovery from isoflurane anaesthesia. Methods: Six mature and healthy horses were premedicated with i.v. xylazine and butorphanol, and anaesthesia induced using ketamine. After 2 h of inhalant anaesthesia with isoflurane vaporised in oxygen, saline solution, xylazine (0.1 mg/kg bwt), detomidine (2 microg/kg bwt) or romifidine (8 pg/kg bwt) were administered. The quality of recovery of each horse and the degree of sedation and ataxia were evaluated. Cardiovascular and respiratory parameters were recorded, and arterial blood samples obtained and analysed for pH, PO2 and PCO2 during recovery. Results: Quality of recovery was better in groups treated with alpha-2 adrenergic receptors agonists, showing less ataxia. Degree of sedation was greater in the romifidine group. Conclusions: We concluded that the administration of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses prolonged and improved the quality of recovery without producing significant cardiorespiratory effects. Conclusions: Administration of alpha-2 adrenoceptor agonists after inhalent anaesthesia could prevent complications during the recovery period.
Get Full Text
Publication Date: 2003-03-18 PubMed ID: 12638794DOI: 10.2746/042516403776114117Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study evaluated the use of alpha-2 adrenoceptor agonists in improving the recovery period of horses after isoflurane anaesthesia, with results showing that these drugs, particularly romifidine, enhanced recovery with little impact on cardiorespiratory criteria.

Study Objective and Methodology

  • The goal of this experiment was to assess and compare the recovery of horses given a saline solution, xylazine, detomidine, or romifidine after isoflurane anaesthesia.
  • In the research, six mature and healthy horses were pre-medicated with intravenous xylazine and butorphanol, and anaesthetised using ketamine.
  • After two hours of inhalant anaesthesia with isoflurane vaporised in oxygen, the horses were administered with either a saline solution, xylazine, detomidine or romifidine at different concentrations.

Evaluation and Results

  • Researchers evaluated the horses’ recovery conditions by observing their degree of sedation and ataxia (lack of muscle control).
  • Cardiovascular and respiratory measures were recorded, and arterial blood samples collected for analysis of pH, PO2 and PCO2 during recovery.
  • The results showed that the use of alpha-2 adrenergic receptor agonists (xylazine, detomidine, or romifidine) improved the condition of recovery, with the horses exhibiting less ataxia.
  • The romifidine-treated group showed a higher degree of sedation than the other groups.

Conclusions

  • The findings suggested that alpha-2 adrenoceptor agonists can enhance the recovery process from isoflurane anaesthesia in horses without causing significant cardiorespiratory effects.
  • The use of these drugs post-inhalant anaesthesia could potentially prevent complications during the recovery period, offering a more calm recovery for horses undergoing anaesthesia.

Cite This Article

APA
Santos M, Fuente M, Garcia-Iturralde R, Herran R, Lopez-Sanroman J, Tendillo FJ. (2003). Effects of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses. Equine Vet J, 35(2), 170-175. https://doi.org/10.2746/042516403776114117

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 35
Issue: 2
Pages: 170-175

Researcher Affiliations

Santos, M
  • Departamento de Patologia Animal II, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda Puerta de Hierro, 28035 Madrid, Spain.
Fuente, M
    Garcia-Iturralde, R
      Herran, R
        Lopez-Sanroman, J
          Tendillo, F J

            MeSH Terms

            • Adrenergic alpha-2 Receptor Agonists
            • Adrenergic alpha-Agonists / administration & dosage
            • Adrenergic alpha-Agonists / pharmacology
            • Anesthesia Recovery Period
            • Anesthesia, General / veterinary
            • Anesthetics, Inhalation
            • Animals
            • Blood Pressure / drug effects
            • Female
            • Heart Rate / drug effects
            • Horses / physiology
            • Imidazoles / administration & dosage
            • Isoflurane
            • Male
            • Receptors, Adrenergic, alpha-2 / drug effects
            • Sodium Chloride / administration & dosage
            • Xylazine / administration & dosage

            Citations

            This article has been cited 13 times.
            1. Murillo C, Weng HY, Weil AB, Kreuzer M, Ko JC. Perioperative Brain Function Monitoring with Electroencephalography in Horses Anesthetized with Multimodal Balanced Anesthetic Protocol Subjected to Surgeries.. Animals (Basel) 2022 Oct 20;12(20).
              doi: 10.3390/ani12202851pubmed: 36290236google scholar: lookup
            2. Rabbogliatti V, Amari M, Brioschi FA, Di Cesare F, Zani DD, De Zani D, Di Giancamillo M, Cagnardi P, Ravasio G. Use of dexmedetomidine repeated subcutaneous administration for balanced anaesthesia in horses.. BMC Vet Res 2022 Jul 11;18(1):269.
              doi: 10.1186/s12917-022-03350-0pubmed: 35818051google scholar: lookup
            3. Gozalo-Marcilla M, Bettschart-Wolfensberger R, Johnston M, Taylor PM, Redondo JI. Data Collection for the Fourth Multicentre Confidential Enquiry into Perioperative Equine Fatalities (CEPEF4) Study: New Technology and Preliminary Results.. Animals (Basel) 2021 Aug 30;11(9).
              doi: 10.3390/ani11092549pubmed: 34573515google scholar: lookup
            4. Vermedal H, Valverde A, Sears W. Effect of anesthesia duration on the quality of recovery in horses undergoing elective and emergency surgeries using the same anesthetic protocol.. Can J Vet Res 2021 Jul;85(3):193-200.
              pubmed: 34248263
            5. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
              doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
            6. Di Salvo A, Chiaradia E, Della Rocca G, Giorgi M, Mancini F, Marenzoni ML, Conti MB, Nannarone S. Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings.. Vet Q 2018 Dec;38(1):129-137.
              doi: 10.1080/01652176.2018.1546963pubmed: 30773122google scholar: lookup
            7. Tokushige H, Okano A, Arima D, Ito H, Kambayashi Y, Minamijima Y, Ohta M. Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery.. Acta Vet Scand 2018 Nov 5;60(1):71.
              doi: 10.1186/s13028-018-0426-0pubmed: 30396363google scholar: lookup
            8. Niimura Del Barrio MC, David F, Hughes JML, Clifford D, Wilderjans H, Bennett R. A retrospective report (2003-2013) of the complications associated with the use of a one-man (head and tail) rope recovery system in horses following general anaesthesia.. Ir Vet J 2018;71:6.
              doi: 10.1186/s13620-018-0117-1pubmed: 29456834google scholar: lookup
            9. Hopster K, Wittenberg-Voges L, Kästner SBR. Xylazine infusion in isoflurane-anesthetized and ventilated healthy horses: Effects on cardiovascular parameters and intestinal perfusion.. Can J Vet Res 2017 Oct;81(4):249-254.
              pubmed: 29081581
            10. Aoki M, Wakuno A, Kushiro A, Mae N, Kakizaki M, Nagata SI, Ohta M. Evaluation of total intravenous anesthesia with propofol-guaifenesin-medetomidine and alfaxalone-guaifenesin-medetomidine in Thoroughbred horses undergoing castration.. J Vet Med Sci 2017 Dec 22;79(12):2011-2018.
              doi: 10.1292/jvms.16-0658pubmed: 29057764google scholar: lookup
            11. Aarnes TK, Bednarski RM, Bertone AL, Hubbell JA, Lerche P. Recovery from desflurane anesthesia in horses with and without post-anesthetic xylazine.. Can J Vet Res 2014 Apr;78(2):103-9.
              pubmed: 24688171
            12. Rioja E, Cernicchiaro N, Costa MC, Valverde A. Perioperative risk factors for mortality and length of hospitalization in mares with dystocia undergoing general anesthesia: a retrospective study.. Can Vet J 2012 May;53(5):502-10.
              pubmed: 23115362
            13. Bauquier SH, Kona-Boun JJ. [Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses].. Can Vet J 2011 Sep;52(9):987-93.
              pubmed: 22379199
            Subscribe to our newsletter
            Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.