Effects of an infusion of dopamine on the cardiopulmonary effects of Escherichia coli endotoxin in anaesthetised horses.
Abstract: Horses with colic may be endotoxaemic and subsequently develop hypotension during anaesthesia for surgical operation. The aim of this study was to evaluate the efficacy of dopamine as a means to improve cardiovascular function in anaesthetised endotoxaemic horses. Nine horses (five in group 1 and four in group 2) were anaesthetised with thiopentone and guaifenesin and anaesthesia was maintained with halothane. After approximately one hour, facial artery pressure, heart rate, pulmonary artery pressure, cardiac output, temperature, pHa, PaCO2, PaO2, base excess, packed cell volume, plasma protein concentration and white cell count were measured (time 0). Escherichia coli endotoxin was infused intravenously over 15 minutes in both groups. Group 2 horses were given an intravenous infusion of dopamine (5 micrograms kg-1 min-1) starting five minutes after the start of the endotoxin infusion and continuing for 60 minutes. Measurements were made at 15 minute intervals for 120 minutes. In group 1, one horse died during the endotoxin infusion and in two other horses mean facial artery pressures decreased to 50 mm Hg. Total pulmonary vascular resistance and packed cell volume were significantly increased. Cardiac output, cardiac index and change in mean arterial pressure were significantly greater in group 2 horses than in group 1 horses. Conversely, diastolic pulmonary artery pressure, total vascular resistance and total pulmonary resistance were significantly less in group 2 than in group 1. PaO2, base excess and white blood cell count were significantly decreased in both groups. It was concluded that dopamine improved cardiovascular function in the presence of endotoxaemia and attenuated the rate of haemoconcentration, but had no effect on the development of decreased PaO2 or metabolic acidosis.
Publication Date: 1991-01-01 PubMed ID: 2047592DOI: 10.1016/0034-5288(91)90053-qGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study investigated whether dopamine improved cardiovascular function in anesthetized horses suffering from endotoxemia, a common complication of colic. The findings revealed dopamine did enhance cardiovascular function and helped manage haemoconcentration but had no impact on low oxygen levels or metabolic acidosis.
Objective of the Research
- The study aimed to discover the efficacy of dopamine in enhancing cardiovascular function in horses experiencing endotoxemia during anaesthesia required due to colic.
Methods Used
- Nine horses were anesthetized and divided into two groups.
- All underwent the same anaesthesia process and had their initial vitals and conditions measured (Time 0).
- Both groups received an intravenous infusion of Escherichia coli endotoxin. Group 2 also received intravenous dopamine five minutes after the endotoxin infusion, with the infusion lasting 60 minutes.
- Vitals were measured every 15 minutes for two hours to observe changes.
Findings of the Research
- In group 1, one horse died during the process, and two others experienced a severe drop in facial artery pressure. Total pulmonary vascular resistance and packed cell volume also increased significantly.
- In contrast, group 2 horses displayed significantly greater cardiac output, cardiac index, and change in mean arterial pressure. They also had significantly lower diastolic pulmonary artery pressure, total vascular resistance, and total pulmonary resistance compared to group 1.
- Both groups showed a significant drop in oxygen levels, base excess, and white blood cell count.
Conclusions
- The research concluded that dopamine can indeed improve the cardiovascular function in horses dealing with endotoxemia. It also seems to manage the haemoconcentration rate effectively. However, it did not affect oxygen levels or metabolic acidosis development.
Cite This Article
APA
Trim CM, Moore JN, Hardee MM, Hardee GE, Slade EA.
(1991).
Effects of an infusion of dopamine on the cardiopulmonary effects of Escherichia coli endotoxin in anaesthetised horses.
Res Vet Sci, 50(1), 54-63.
https://doi.org/10.1016/0034-5288(91)90053-q Publication
Researcher Affiliations
- Department of Large Animal Medicine, University of Georgia, Athens 30602.
MeSH Terms
- Acid-Base Equilibrium / drug effects
- Anesthesia / veterinary
- Animals
- Blood Glucose / analysis
- Dopamine / pharmacology
- Endotoxins / toxicity
- Escherichia coli
- Female
- Halothane
- Hematocrit / veterinary
- Hemodynamics / drug effects
- Horse Diseases / physiopathology
- Horses
- Hydrogen-Ion Concentration
- Lactates / blood
- Leukocyte Count / veterinary
- Male
- Oxygen / blood
- Toxemia / physiopathology
- Toxemia / veterinary
Citations
This article has been cited 1 times.- Mendoza FJ, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara CA, De Las Heras A, Perez-Ecija A. Hemodynamic Response to Lipopolysaccharide Infusion and Effect of Meloxicam Administration on Cardiac Function in Donkeys. Animals (Basel) 2024 Dec 18;14(24).
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