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American journal of veterinary research2005; 66(4); 569-573; doi: 10.2460/ajvr.2005.66.569

Effects of caffeine on exercise performance of physically fit Thoroughbreds.

Abstract: To determine the effects of a dose of caffeine (2.5 mg/kg, IV) administered to physically fit Thoroughbreds during incremental exercise testing to fatigue on a treadmill. Methods: 10 conditioned Thoroughbreds. Methods: Horses were randomly assigned to receive caffeine or a control solution. Each horse received both treatments in a crossover design with a 3-week interval between treatments. Each horse was administered caffeine (2.5 mg/kg) or an equivalent amount of a control solution IV. One hour after injection, each horse performed an incremental exercise test to exhaustion. Hematologic values, heart rate, oxygen consumption, carbon dioxide production, plasma lactate concentration, urine and serum concentrations of caffeine and metabolites, and time until exhaustion were monitored. Statistical analysis was performed by use of a mixed-effects linear model. Results: Significant differences in measured values when horses were treated with caffeine or the control solution were not detected. Conclusions: A dose of caffeine (2.5 mg/kg, IV) appears to have no effect on any performance variable of physically fit Thoroughbreds during incremental exercise testing to fatigue.
Publication Date: 2005-05-20 PubMed ID: 15900934DOI: 10.2460/ajvr.2005.66.569Google Scholar: Lookup
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  • Journal Article

Summary

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The research aimed to investigate the effect of caffeine dosage on the performance of physically fit Thoroughbred horses. Surprisingly, the results indicated that caffeine had no significant impact on performance variables during exhaustive incremental exercise testing.

Research Methods

  • The research involved 10 physically fit Thoroughbreds subjected to exercise testing that escalated in intensity until each horse reached fatigue.
  • A randomized crossover design was used to compare effects of caffeine with a control solution, with each horse receiving both treatments. A three-week interval was assigned between each treatment to ensure any residual effects of the first substance had waned.
  • Each participant horse was injected with a dose of 2.5 mg/kg of caffeine or an equivalent amount of the control solution.
  • About an hour after the administration of respective treatments, the thoroughbreds underwent an incremental exercise test aimed at inducing exhaustion.

Measurements and Results

  • The report focused on various parameters such as hematological values, heart rate, oxygen consumption, carbon dioxide production, plasma lactate concentration, and the time until exhaustion. In addition, urine and serum concentrations of caffeine and its metabolites were also monitored.
  • All data were then statistically analyzed using a mixed-effects linear model to detect any significant variance between the caffeine and control groups.
  • The results revealed no discernible difference in any of the performance variables measured between the horses that received caffeine and those that received the control solution.
  • Hence, it was concluded that a dose of caffeine (2.5 mg/kg, IV) does not significantly affect any performance variable of physically fit Thoroughbreds under exhaustive incremental exercise testing.

Implications and Conclusions

  • The findings of this study challenge the traditional belief that caffeine enhances athletic performance. In this study’s context, caffeine does not seem to affect physically fit Thoroughbreds’ performance parameters during extreme exercise.
  • However, further research may be necessary to explore if variations in the dosage, administration method, or timing of caffeine intake would result in noticeable performance shifts.

Cite This Article

APA
Savage KA, Colahan PT, Tebbett IR, Rice BL, Freshwater LL, Jackson CA. (2005). Effects of caffeine on exercise performance of physically fit Thoroughbreds. Am J Vet Res, 66(4), 569-573. https://doi.org/10.2460/ajvr.2005.66.569

Publication

ISSN: 0002-9645
NlmUniqueID: 0375011
Country: United States
Language: English
Volume: 66
Issue: 4
Pages: 569-573

Researcher Affiliations

Savage, Kathleen A
  • Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136, USA.
Colahan, Patrick T
    Tebbett, Ian R
      Rice, Brett L
        Freshwater, Lester L
          Jackson, Christie A

            MeSH Terms

            • Animals
            • Caffeine / blood
            • Caffeine / pharmacology
            • Caffeine / urine
            • Carbon Dioxide / metabolism
            • Central Nervous System Stimulants / blood
            • Central Nervous System Stimulants / pharmacology
            • Central Nervous System Stimulants / urine
            • Cross-Over Studies
            • Female
            • Heart Rate / drug effects
            • Heart Rate / physiology
            • Horses / blood
            • Horses / physiology
            • Horses / urine
            • Lactic Acid / blood
            • Male
            • Oxygen Consumption / drug effects
            • Oxygen Consumption / physiology
            • Physical Conditioning, Animal / physiology
            • Random Allocation

            Citations

            This article has been cited 1 times.
            1. Darbandi H, Munsters C, Parmentier J, Havinga P. Detecting fatigue of sport horses with biomechanical gait features using inertial sensors.. PLoS One 2023;18(4):e0284554.
              doi: 10.1371/journal.pone.0284554pubmed: 37058516google scholar: lookup