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Home / Equine Research Bank / Vet Res Commun / Effects of cromolyn in horses with chronic obstructive pulmo...
Veterinary research communications1987; 11(4); 339-351; doi: 10.1007/BF00346192

Effects of cromolyn in horses with chronic obstructive pulmonary disease.

Abstract: The effect of disodium cromoglycate (cromolyn) in preventing the pulmonary dysfunction caused by the inhalation of barn and hay dust was studied in 5 horses with confirmed chronic obstructive pulmonary disease (COPD). The horses were studied before (Con) and after exposure to hay and dust allergens (Expos) and after pretreatment with cromolyn followed by exposure (Cr-Expos). There was a significant reduction in PaO2 from 86.8 +/- 8.3 to 73.1 +/- 8.8 when the horses were exposed to hay and dust allergens. The PaO2 after pretreatment with cromolyn and exposures was 78.1 +/- 5.5. There were no significant changes in PaCO2, FRC, pH and A-aDO2 when the Con, Expos, and Cr-Expos periods were compared. There were significant increases in VE from a control value of 77.9 +/- 18.2 to 128.7 +/- 55.1 and 133.7 +/- 17.1 L/min during the exposures, which was due primarily to increases in respiratory frequency. Respiratory dead space (VD/VT) increased from 0.55 +/- 0.10 to 0.71 +/- 0.07 and 0.65 +/- 0.05, and alveolar ventilation (VA) remained constant. Pulmonary resistance (RL) and transpulmonary pressure (Ptr) increased from a control of 0.77 +/- 0.28 cm H2O/L/sec and 7.73 +/- 3.38 cm H2O to 2.93 +/- 1.01 and 20.17 +/- 4.81 during the Expos period and tidal volume (VT) fell from 7.5 +/- 1.0 to 5.7 +/- 1.3 L. The pre-treatment with cromolyn before exposures significantly reduced the increase in RL and Ptr and returned VT to Con levels.
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Publication Date: 1987-01-01 PubMed ID: 3118560DOI: 10.1007/BF00346192Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study explores the effectiveness of Cromolyn in alleviating pulmonary dysfunction in horses due to the inhalation of barn and hay dust. In horses with confirmed Chronic Obstructive Pulmonary Disease (COPD), Cromolyn was found to significantly mitigate detriments in oxygen level and helped maintain consistent levels of breath volume and lung function.

Methodology

  • The experiment was conducted on five horses which were confirmed to have Chronic Obstructive Pulmonary Disease (COPD).
  • The horses were studied in three stages: before exposure to hay and dust allergens (Con), after exposure to allergens (Expos), and after pre-treatment with the drug Cromolyn followed by exposure (Cr-Expos).

Exposure to Allergens

  • Following allergen exposure, it was observed that the oxygen level or PaO2 in the horses fell significantly, from an average of 86.8 (± 8.3) to 73.1 (± 8.8).
  • No significant changes were observed in PaCO2, FRC, pH and A-aDO2 during the Con, Expos and Cr-Expos stages.
  • During exposure to allergens, a significant increase in ventilation (VE) was observed, from a control level of 77.9 (± 18.2) to 128.7 (± 55.1) and 133.7 (± 17.1) L/min.
  • Respiratory dead space (VD/VT) increased from an average of 0.55 (± 0.10) to 0.71 (± 0.07) and 0.65 (± 0.05), while alveolar ventilation (VA) remained constant.
  • Pulmonary resistance (RL) and transpulmonary pressure (Ptr) also increased from a control value of 0.77 (± 0.28) cm H2O/L/sec and 7.73 (± 3.38) cm H2O to 2.93 (± 1.01) and 20.17 (± 4.81) during the exposure period.
  • Additionally, the tidal volume (VT) fell from 7.5 (± 1.0) to 5.7 (± 1.3) L during the exposure period.

Application of Cromolyn

  • Carrying out pre-treatment with Cromolyn before the allergen exposure revealed that Cromolyn was effective in reducing the increase in RL and Ptr witnessed during the exposure period.
  • After the Cromolyn pre-treatment, the horses’ oxygen level or PaO2 was found to be 78.1 (± 5.5), which was significantly improved compared to when the horses were exposed to allergens without pre-treatment.
  • Notably, the use of Cromolyn also helped bring the tidal volume (VT) back to control levels.

Cite This Article

APA
Soma LR, Beech J, Gerber NH. (1987). Effects of cromolyn in horses with chronic obstructive pulmonary disease. Vet Res Commun, 11(4), 339-351. https://doi.org/10.1007/BF00346192

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 11
Issue: 4
Pages: 339-351

Researcher Affiliations

Soma, L R
  • Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square 19348.
Beech, J
    Gerber, N H

      MeSH Terms

      • Animals
      • Cromolyn Sodium / therapeutic use
      • Female
      • Horse Diseases / blood
      • Horse Diseases / drug therapy
      • Horse Diseases / physiopathology
      • Horses
      • Lung Diseases, Obstructive / blood
      • Lung Diseases, Obstructive / drug therapy
      • Lung Diseases, Obstructive / physiopathology
      • Lung Diseases, Obstructive / veterinary
      • Male
      • Respiration

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      Citations

      This article has been cited 2 times.
      1. Hare JE, Viel L, Conlon PD, Marshall JS. Evaluation of an in vitro degranulation challenge procedure for equine pulmonary mast cells. Can J Vet Res 1998 Apr;62(2):133-9.
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