Effects of dietary glycaemic response after exercise on blood concentrations of substrates used indirectly for muscle glycogenesis.
Abstract: Exercise depletes muscle glycogen stores, which could subsequently impair performance. Muscle glycogen replenishment is determined by substrate availability. Objective: To study the effects of feeding meals of varying glycaemic responses on blood concentrations of substrates used for glycogenesis in horses with exercise-induced glycogen depletion. Methods: In a 3-way crossover study, 7 horses received each of 3 isocaloric diets for 72 h after undergoing glycogen-depleting exercise: 1) a high soluble-carbohydrate diet, which induced a high-glycaemic (HGI) response; 2 and 3) a low soluble-carbohydrate or a mixed soluble-carbohydrate diet (control group), which both induced a similar low-to-moderate glycaemic (LGI) response. Muscle biopsies and venous samples were collected before and up to 72 h after exercise. Results: Feeding HGI diet resulted in a higher (P<0.001) rate of muscle glycogenesis over 72 h compared to LGI diets. Plasma glycerol, triglyceride, lactate, serum NEFA and total protein concentrations, and haematocrit were significantly (P<0.001) higher after compared to before exercise. Whereas no significant overall dietary effect was observed on these metabolites over 72 h, there was a tendency for glycerol, NEFA and triglyceride concentrations to be lower for LGI compared to HGI diets over 6 h after exercise (P<0.05; 1, 6 and 4-6 h after exercise, respectively). Conclusions: These data suggest that horses fed LGI meals after exercise had limited lipid utilisation without any significant shift of substrate utilisation toward gluconeogenesis, which could have contributed to the slower rate of muscle glycogenesis compared to horses fed HGI diets.
Publication Date: 2007-04-04 PubMed ID: 17402488DOI: 10.1111/j.2042-3306.2006.tb05609.xGoogle Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research investigated how different diets can affect the replenishment of muscle glycogen in horses after exercise. The study found that meals with a high glycaemic response lead to a faster recovery of muscle glycogen compared to meals with a low to moderate glycaemic response.
Research Methodology
- The study was conducted with a sample of seven horses and followed a three-way crossover design.
- Each horse was subjected to an exercise that depleted their muscle glycogen stores.
- After the exercise, the horses were given one of the three isocaloric diets: a high soluble carbohydrate diet that induced a high glycaemic response (HGI), a low soluble carbohydrate diet, or a mixed soluble carbohydrate diet, both of which induced a low to moderate glycaemic response (LGI).
- The diets were given for a period of 72 hours after the exercise.
- Throughout the duration of the study, muscle biopsies and venous samples were collected before and after the exercise.
Research Findings
- The high glycaemic index (HGI) diet led to a significantly higher rate of muscle glycogenesis over 72 hours than the low glycaemic index (LGI) diets.
- Metabolites such as plasma glycerol, triglyceride, lactate, serum NEFA and total protein concentrations, and haematocrit were significantly higher after compared to before the exercise.
- Even though no significant overall dietary effect was observed on these metabolites over 72 hours, there was a tendency for glycerol, NEFA, and triglyceride concentrations to be lower for LGI diets compared to HGI diets over the first six hours after exercise.
Conclusion
- The data suggested that horses fed on LGI meals after exercise had limited lipid utilization without a significant shift of substrate utilization towards gluconeogenesis.
- This could have contributed to the slower rate of muscle glycogenesis observed in horses fed LGI diets when compared to those fed HGI diets.
Cite This Article
APA
Lacombe VA, Hinchcliff KW, Kohn CW, Reed SM, Taylor LE.
(2007).
Effects of dietary glycaemic response after exercise on blood concentrations of substrates used indirectly for muscle glycogenesis.
Equine Vet J Suppl(36), 585-589.
https://doi.org/10.1111/j.2042-3306.2006.tb05609.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, USA.
MeSH Terms
- Animal Feed / analysis
- Animal Feed / classification
- Animal Nutritional Physiological Phenomena
- Animals
- Area Under Curve
- Cross-Over Studies
- Dietary Carbohydrates / administration & dosage
- Dietary Carbohydrates / classification
- Dietary Carbohydrates / metabolism
- Glycemic Index
- Glycogen / biosynthesis
- Horses / metabolism
- Horses / physiology
- Male
- Muscle, Skeletal / metabolism
- Physical Conditioning, Animal / physiology
- Time Factors
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