Effects of misoprostol and omeprazole on basal gastric pH and free acid content in horses.
Abstract: The basal gastric pH and free acid contents from five young adult healthy horses were determined at one hour intervals for eight hours. The basal gastric pH and free acid contents varied from 1.63 +/- 0.06 to 1.97 +/- 0.11 and 26.42 +/- 4.14 to 17.92 +/- 5.28 mmol litre-1, respectively. Misoprostol, a methylester analogue of prostaglandin (5 micrograms kg-1, orally) produced a time-dependent increase in the basal gastric pH to above 3.5 (P less than 0.05) at three, four and five hours after administration with a concomitant reduction of 80 to 90 per cent in the basal gastric free acid contents throughout the eight hour period monitored. Omeprazole, a benzimidazole derivative (0.5 mg kg-1, intravenously) increased the basal gastric pH to above 3.5 at two and three hours after administration with a concomitant reduction of 65 to 90 per cent in the basal gastric free acid contents for seven of the eight hour periods monitored. These results confirm that the horse is a basal acid secretor, and both misoprostol and omeprazole are effective inhibitors of the basal gastric acid secretion, thus establishing that both prostaglandins and H+/K+-ATPase play an important role in controlling parietal cell function of the equine gastric mucosa.
Publication Date: 1989-11-01 PubMed ID: 2512598
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study investigates the influence of two drugs, misoprostol and omeprazole, on the gastric pH and acid content in horses, ultimately revealing that both drugs successfully inhibit gastric acid secretion.
Study Details
- The study was performed on five young adult healthy horses. Their basal gastric pH and free acid content were measured every hour, for a period of eight hours.
- The observed pH and free acid content differed slightly per horse, with an overall average of 1.63 +/- 0.06 to 1.97 +/- 0.11 for pH, and 26.42 +/- 4.14 to 17.92 +/- 5.28 mmol litre-1 for the free acid content.
The Use of Misoprostol
- The horses were then given misoprostol, an analogue of prostaglandin, by oral administration. This drug is commonly used to prevent stomach ulcers and to induce labor or abortion in humans.
- The use of misoprostol resulted in a significant increase in the horses’ gastric pH, lasting about three to five hours post-administration. This was accompanied by a decrease of 80 to 90% in the gastric free acid content over the entire eight-hour observation period.
The Use of Omeprazole
- The researchers also tested the effects of omeprazole, a drug usually used in humans to reduce the amount of acid the stomach produces. This compound was given to the horses through intravenous administration.
- Just like misoprostol, omeprazole led to an increased gastric pH level, evidenced two to three hours after application. In addition, it brought about a decrease of 65 to 90% in the free acid content almost throughout the entire eight-hour period.
Conclusion
- The results confirmed the horses to be basal acid secretors, meaning they naturally produce a significant amount of gastric acid.
- Both drugs – misoprostol and omeprazole – were found to effectively inhibit this acid production in the stomach. This points to the crucial role of both prostaglandins and H+/K+-ATPase, an enzyme facilitating the exchange of hydrogen and potassium ions, in controlling the functionality of parietal cells in the horses’ gastric mucosa.
Cite This Article
APA
Sangiah S, MacAllister CC, Amouzadeh HR.
(1989).
Effects of misoprostol and omeprazole on basal gastric pH and free acid content in horses.
Res Vet Sci, 47(3), 350-354.
Publication
Researcher Affiliations
- Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, 74078.
MeSH Terms
- Administration, Oral
- Alprostadil / administration & dosage
- Alprostadil / analogs & derivatives
- Alprostadil / pharmacology
- Animals
- Anti-Ulcer Agents / administration & dosage
- Anti-Ulcer Agents / pharmacology
- Gastric Acid / metabolism
- Gastric Acidity Determination / veterinary
- Gastric Mucosa / drug effects
- Gastric Mucosa / metabolism
- Horses / metabolism
- Hydrogen-Ion Concentration
- Injections, Intravenous / veterinary
- Misoprostol
- Omeprazole / administration & dosage
- Omeprazole / pharmacology
- Random Allocation
Citations
This article has been cited 6 times.- Vokes J, Lovett A, Sykes B. Equine Gastric Ulcer Syndrome: An Update on Current Knowledge. Animals (Basel) 2023 Apr 5;13(7).
- Martin EM, Schirmer JM, Jones SL, Davis JL. Pharmacokinetics and ex vivo anti-inflammatory effects of oral misoprostol in horses. Equine Vet J 2019 May;51(3):415-421.
- Martin EM, Messenger KM, Sheats MK, Jones SL. Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes. Front Vet Sci 2017;4:160.
- Martin EM, Till RL, Sheats MK, Jones SL. Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation. Front Vet Sci 2017;4:159.
- Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003 Jul;44(7):581-5.
- Dowling PM. Therapy of gastrointestinal ulcers. Can Vet J 1995 May;36(5):276-7.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
