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Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial.
Abstract: A multicentre, blinded, randomised complete-block, field trial was conducted with 140 horses and foals age 4 weeks-28 years to determine if omeprazole paste is effective and safe in promoting healing of spontaneous gastric ulcers under a variety of field conditions and in different breeds and ages of horses. Horses in the study had gastric ulceration as determined by gastroscopy and were divided into replicates of 4 or 5 animals. One horse in each replicate was assigned randomly to receive an empty omeprazole syringe (sham-dosed control) and the remaining horses received omeprazole paste once daily for 28 days. Gastroscopy was repeated at the end of the study. Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls. Ulcers were improved in 32.4 and 99.0% of the control and omeprazole groups, respectively. Ulcers were completely healed in 8.9 and 86.7% of the control and omeprazole groups, respectively. Under typical field conditions, omeprazole was effective at enhancing healing of spontaneous gastric ulcers in horses of a variety of ages and breeds.
Publication Date: 2000-03-04 PubMed ID: 10696300DOI: 10.1111/j.2042-3306.1999.tb05175.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Multicenter Study
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The study investigates the impact of omeprazole paste on the healing of spontaneous gastric ulcers in horses and foals. It establishes that omeprazole significantly improved ulcer healing in the tested animals compared to those left untreated.
Introduction
- The field trial was a multicentre, blinded, randomised complete-block research, carried out on a total of 140 horses and foals. The age of these animals ranged between 4 weeks to 28 years. The purpose was to determine the effectiveness and safety of omeprazole paste in enhancing the healing of spontaneous gastric ulcers.
Methodology
- The selected horses in the study had been diagnosed with gastric ulceration by gastroscopy. They were divided into groups of 4 or 5 animals.
- In each group, one horse was given a placebo, in the form of an empty omeprazole syringe. This horse acted as the sham-dosed control. The rest of the horses received omeprazole paste once every day for a period of 28 days.
- At the end of the study, a second gastroscopy was conducted.
Results
- Based on the results, there was a significant improvement (P < 0.01) in the ulcer scores for the horses that were treated with omeprazole paste when compared to the control group given the placebo.
- Improvements were noted in 32.4% and 99.0% of the control and omeprazole groups, respectively. This indicated a much higher rate of improvement in the group receiving the omeprazole treatment.
- Complete healing of ulcers was observed in 8.9% of the control group and 86.7% of the omeprazole group, underlining the effectiveness of the omeprazole paste.
Conclusion
- From the results, the study concludes that under normal field conditions, omeprazole paste is effective at improving the healing of spontaneous gastric ulcers. This finding was consistent across horses of different ages and breeds.
Cite This Article
APA
MacAllister CG, Sifferman RL, McClure SR, White GW, Vatistas NJ, Holste JE, Ericcson GF, Cox JL.
(2000).
Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial.
Equine Vet J Suppl(29), 77-80.
https://doi.org/10.1111/j.2042-3306.1999.tb05175.x Publication
Researcher Affiliations
- College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
MeSH Terms
- Administration, Oral
- Age Factors
- Animals
- Animals, Newborn
- Breeding
- Double-Blind Method
- Enzyme Inhibitors / administration & dosage
- Enzyme Inhibitors / therapeutic use
- Female
- Gastroscopy / veterinary
- Horse Diseases / drug therapy
- Horses
- Housing, Animal
- Male
- Ointments
- Omeprazole / administration & dosage
- Omeprazole / therapeutic use
- Severity of Illness Index
- Stomach Ulcer / drug therapy
- Stomach Ulcer / veterinary
- Treatment Outcome
- United States
Citations
This article has been cited 13 times.- Shan R, Steel CM, Sykes B. The Impact of Two Recommended Withholding Periods for Omeprazole and the Use of a Nutraceutical Supplement on Recurrence of Equine Gastric Ulcer Syndrome in Thoroughbred Racehorses. Animals (Basel) 2023 May 31;13(11).
- Williams Louie E, Nieto J, Wensley F, Morgan JM, Finno CJ, Berryhill EH. Efficacy of the oral supplement, Equine Omega Complete, for the prevention of gastric ulcers and alpha-tocopherol supplementation in horses. J Vet Intern Med 2023 Nov-Dec;37(6):2529-2534.
- Gough S, Hallowell G, Rendle D. Evaluation of the treatment of equine glandular gastric disease with either long-acting-injectable or oral omeprazole. Vet Med Sci 2022 Mar;8(2):561-567.
- Hewetson M, Tallon R. Equine Squamous Gastric Disease: Prevalence, Impact and Management. Vet Med (Auckl) 2021;12:381-399.
- Wise JC, Hughes KJ, Edwards S, Jacobson GA, Narkowicz CK, Raidal SL. Pharmacokinetic and pharmacodynamic effects of 2 registered omeprazole preparations and varying dose rates in horses. J Vet Intern Med 2021 Jan;35(1):620-631.
- Wise JC, Wilkes EJA, Raidal SL, Xie G, Crosby DE, Hale JN, Hughes KJ. Interobserver and intraobserver reliability for 2 grading systems for gastric ulcer syndrome in horses. J Vet Intern Med 2021 Jan;35(1):571-579.
- Gough S, Hallowell G, Rendle D. A study investigating the treatment of equine squamous gastric disease with long-acting injectable or oral omeprazole. Vet Med Sci 2020 May;6(2):235-241.
- Banse HE, Andrews FM. Equine glandular gastric disease: prevalence, impact and management strategies. Vet Med (Auckl) 2019;10:69-76.
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
- Woodward MC, Huff NK, Garza F Jr, Keowen ML, Kearney MT, Andrews FM. Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses. BMC Vet Res 2014;10 Suppl 1(Suppl 1):S4.
- Birkmann K, Junge HK, Maischberger E, Wehrli Eser M, Schwarzwald CC. Efficacy of omeprazole powder paste or enteric-coated formulation in healing of gastric ulcers in horses. J Vet Intern Med 2014 May-Jun;28(3):925-33.
- Hellings IR, Larsen S. ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand 2014 Mar 13;56(1):13.
- Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003 Jul;44(7):581-5.
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