Effects of pre-shipping enrofloxacin administration on fever and blood properties in adult Thoroughbred racehorses transported a long distance.
Abstract: To evaluate the effects of single-dose enrofloxacin (ERFX) on fever and blood properties in 68 Thoroughbred racehorses after long-distance transportation, horses were assigned to receive ERFX (5 mg/kg, IV; ERFX group; n=52) or saline (0.9% NaCl) solution (50 ml, IV; control group; n=16) ≤1 hr before transportation. Horses were transported 1,122 km using commercial vans over the course of approximately 21 hr. Clinical examinations and hematologic analyses were performed before and after transportation. Rectal temperatures, white blood cell counts and serum amyloid A concentration of ERFX group were significantly lower than control group (P<0.01, P<0.01 and P<0.05, respectively). In conclusion, these results show ERFX administration just before transportation is effective at preventing transportation-associated fever in adult Thoroughbred racehorses.
Publication Date: 2017-01-22 PubMed ID: 28111418PubMed Central: PMC5383162DOI: 10.1292/jvms.16-0465Google Scholar: Lookup
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- Clinical Trial
- Journal Article
Summary
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The research article investigates the effects of administering the antibiotic enrofloxacin on fever and blood properties in Thoroughbred racehorses following long-distance transportation. The results indicate that the administration of enrofloxacin prior to transportation effectively prevents transportation-associated fever in these horses.
Methodology
- The study involved a total of 68 Thoroughbred racehorses, some of which were given a single dose of enrofloxacin (5 mg/kg, IV; ERFX group; n=52), while the remaining were given a saline (0.9% NaCl) solution (50 ml, IV; control group; n=16).
- The administration of either the antibiotic or the saline solution was performed no more than an hour before transportation.
- The horses were transported over a distance of 1,122 km using commercial vehicles, and the journey approximately lasted for 21 hours.
- Both before and after transportation, the horses underwent clinical examinations and hematologic analyses.
Outcomes
- The findings from the examination revealed that rectal temperatures, white blood cell counts, and serum amyloid A concentration (a marker of inflammation) in the horses from the ERFX group were significantly lower than the horses in the control group. The significance was measure using a statistical test with a threshold for P values less than 0.01 and 0.05.
- The results showed statistically significant differences between the ERFX group and the control group, which indicates that the administration of ERFX has a beneficial effect on the horses’ health following long-distance transportation.
Conclusion
- Based on the above findings, the study concludes that providing Thoroughbred racehorses with a dose of the antibiotic enrofloxacin before they are transported long distances is an effective measure in the prevention of a transportation-related fever.
- However, whether this approach can be generalized to horses of other breeds or those in different health conditions may require further research.
Cite This Article
APA
Endo Y, Ishikawa Y, Arima D, Mae N, Iwamoto Y, Korosue K, Tsuzuki N, Hobo S.
(2017).
Effects of pre-shipping enrofloxacin administration on fever and blood properties in adult Thoroughbred racehorses transported a long distance.
J Vet Med Sci, 79(3), 464-466.
https://doi.org/10.1292/jvms.16-0465 Publication
Researcher Affiliations
- Miyazaki Yearling Training Farm, Japan Racing Association, Miyazaki 880-0036, Japan.
MeSH Terms
- Animals
- Enrofloxacin
- Female
- Fever / blood
- Fever / etiology
- Fever / prevention & control
- Fever / veterinary
- Fluoroquinolones / therapeutic use
- Horse Diseases / blood
- Horse Diseases / etiology
- Horse Diseases / prevention & control
- Horses
- Male
- Stress, Physiological / drug effects
- Transportation
References
This article includes 15 references
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Citations
This article has been cited 3 times.- Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar Schmidt C, Michel V, Miranda Chueca MÁ, Padalino B, Pasquali P, Roberts HC, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Earley B, Edwards S, Faucitano L, Marti S, Miranda de La Lama GC, Costa LN, Thomsen PT, Ashe S, Mur L, Van der Stede Y, Herskin M. Welfare of equidae during transport. EFSA J 2022 Sep;20(9):e07444.
- Minamijima Y, Niwa H, Uchida E, Yamamoto K. Comparison of the proteomes in sera between healthy Thoroughbreds and Thoroughbreds with respiratory disease associated with transport using mass spectrometry-based proteomics. J Equine Sci 2021 Mar;32(1):11-15.
- Zhao H, Tang X, Wu M, Li Q, Yi X, Liu S, Jiang J, Wang S, Sun X. Transcriptome Characterization of Short Distance Transport Stress in Beef Cattle Blood. Front Genet 2021;12:616388.
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