Effects of pre-shipping marbofloxacin administration on fever and blood properties in healthy Thoroughbreds transported a long distance.
Abstract: The present study evaluated the effects of single-dose marbofloxacin in protecting horses against fever associated with transportation using 48 healthy Thoroughbreds. All horses were premedicated with interferon-α (0.5 U/kg, sublingually, every 24 hr) for 2 days before transportation and on the day of transportation. Horses were randomly assigned to receive marbofloxacin (2 mg/kg, IV, once; MRFX group), enrofloxacin (5 mg/kg, IV, once; ERFX group) or saline (0.9% NaCl) solution (10 ml, IV, once; control group) ≤1 hr before being transportation. Each group contained 16 horses (8 males, 8 females). Horses were transported 1,210 km using commercial vans over the course of approximately 26 hr. Clinical examinations and hematologic analyses were performed on all horses both before and after transportation. Post-transportation neutrophil to lymphocyte ratios were significantly lower in horses in the MRFX group compared with the control horses. The serum amyloid A levels were significantly lower in horses in the MRFX group and ERFX group compared with the control horses. Regarding the post-transportation rectal temperatures, fever was detected in 0 horses and 1 horse in the MRFX and ERFX groups, respectively, whereas fevers exceeding 39.1°C were detected in 2 horses in the control group. Additionally, the number of essential post-transportation treatments provided by veterinarians was reduced 3-fold in the MRFX and ERFX groups compared with the saline group. MRFX provided ERFX-like protection against fever associated with long-distance transportation, yielding significantly better protection than saline. Administration of MRFX just before transportation deserves a further study for efficacy in preventing horse fever associated with transportation.
Publication Date: 2014-10-29 PubMed ID: 25720808PubMed Central: PMC4349540DOI: 10.1292/jvms.14-0336Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The research explores the effects of administering a single-dose of marbofloxacin to horses before long-distance transportation, finding it significantly reduces the occurrence of post-transportation fever.
Study Design
- The study included 48 healthy Thoroughbred horses which were all premedicated with interferon-α for two days before the scheduled transport and on the day of transportation.
- The horses were randomly divided into three groups: marbofloxacin (MRFX group), enrofloxacin (ERFX group), and a saline solution (control group). Each medication was administered intravenously one hour or less before the horses were transported.
- Each group contained an equal number of males and females (8 each). The horses traveled 1,210 km using commercial vans, a journey that took around 26 hours.
- Clinical examinations and hematologic analyses were performed on the horses both before and after their journeys.
Outcomes and Findings
- The ratio of neutrophils to lymphocytes (indicators of inflammation or infection) in the horses’ blood was significantly lower in the MRFX group compared to the control horses after transportation.
- The serum amyloid A levels (another marker of inflammation) were also significantly lower in the MRFX group and ERFX group compared to the control horses post-transport.
- Interestingly, none of the horses in the MRFX group experienced a post-transportation fever, and only one horse in the ERFX group had a fever. In contrast, two horses in the control group developed fevers exceeding 39.1°C after the journey.
- The researchers noted a reduction in the need for post-transportation veterinary treatments in the MRFX and ERFX groups, indicating a positive effect of the medications on the horses’ overall condition.
- The results showed a similar level of protection against post-transit fever provided by MRFX and ERFX, with both significantly more effective than a saline solution.
Conclusions and Future Directions
- These findings suggest that administering marbofloxacin just before transporting horses for long distances could effectively prevent fevers associated with such transportation.
- However, the researchers acknowledge the need for additional studies to further establish the efficiency of marbofloxacin administration in preventing transportation-related horse fever.
Cite This Article
APA
Endo Y, Tsuchiya T, Omura T, Nakai K, Korosue K, Ishimaru M, Ishikawa Y, Hobo S.
(2014).
Effects of pre-shipping marbofloxacin administration on fever and blood properties in healthy Thoroughbreds transported a long distance.
J Vet Med Sci, 77(1), 75-79.
https://doi.org/10.1292/jvms.14-0336 Publication
Researcher Affiliations
- Hidaka Training and Research Center, Japan Racing Association, 535-13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057-0171 Japan.
MeSH Terms
- Animals
- Anti-Bacterial Agents / administration & dosage
- Anti-Bacterial Agents / therapeutic use
- Enrofloxacin
- Female
- Fever / prevention & control
- Fever / veterinary
- Fluoroquinolones / administration & dosage
- Fluoroquinolones / therapeutic use
- Horse Diseases / blood
- Horse Diseases / prevention & control
- Horses
- Male
- Transportation
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Citations
This article has been cited 5 times.- Sato W, Sukmawinata E, Uemura R, Kanda T, Kusano K, Kambayashi Y, Sato T, Ishikawa Y, Toya R, Sueyoshi M. Antimicrobial resistance profiles and phylogenetic groups of Escherichia coli isolated from healthy Thoroughbred racehorses in Japan.. J Equine Sci 2020;31(4):85-91.
- Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
- Endo Y, Ishikawa Y, Arima D, Mae N, Iwamoto Y, Korosue K, Tsuzuki N, Hobo S. Effects of pre-shipping enrofloxacin administration on fever and blood properties in adult Thoroughbred racehorses transported a long distance.. J Vet Med Sci 2017 Mar 18;79(3):464-466.
- Endo Y, Hobo S, Korosue K, Ootsuka K, Kitauchi A, Kikkawa R, Hidaka Y, Hagio M, Tsuzuki N. Effects of low-dose G-CSF formulation on hematology in healthy horses after long-distance transportation.. J Vet Med Sci 2015 Apr;77(4):507-9.
- Endo Y, Tsuchiya T, Akiyama K, Takebe N, Nakai K, Korosue K, Ishimaru M, Tsuzuki N, Hobo S. Comparison of the Occurrence of Transportation-associated Fever in 2 Years Old Thoroughbreds before and after Introduction of Prophylactic Marbofloxacin Administration.. J Equine Sci 2014;25(4):79-81.
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