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The Veterinary record2005; 156(17); 538-542; doi: 10.1136/vr.156.17.538

Effects of surgery on the acute phase response in clinically normal and diseased horses.

Abstract: The serum concentrations of serum amyloid A, haptoglobin and fibrinogen were measured in a group of horses before and at intervals after elective and non-elective surgery, and in a control group of normal horses. There was a significant, rapid and repeatable increase in the concentration of serum amyloid A in response to both elective and non-elective surgery. In the control horses its serum concentration was within the normal range, from 0 to 0.2 microg/ml. Twenty-four hours after elective surgery its mean peak concentration was 16.4 microg/ml, and after non-elective surgery it was 27.3 microg/ml. In contrast, the serum concentrations of haptoglobin and fibrinogen increased more slowly after surgery and had not decreased by 72 hours after surgery.
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Publication Date: 2005-04-26 PubMed ID: 15849343DOI: 10.1136/vr.156.17.538Google Scholar: Lookup
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  • Clinical Trial
  • Journal Article
  • Randomized Controlled Trial

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines the effects of surgery-induced physiological changes on horses, particularly on the levels of serum amyloid A, haptoglobin and fibrinogen, to gain a better understanding of surgery-related inflammatory responses in equine medicine.

Study Procedure and Participants

  • The research included three groups of horses: horses undergoing elective surgery, horses undergoing non-elective surgery and a control group of healthy horses.
  • The set of horses scheduled for surgery (either elective or non-elective) were measured for serum concentrations of serum amyloid A, haptoglobin and fibrinogen before the procedure and at various intervals afterwards.
  • The researchers then compared these results with the control group of healthy horses.

Findings

  • The levels of serum amyloid A, a significant marker of inflammation, in horses that had undergone surgery was remarkably higher than in healthy horses.
  • The average peak concentration of serum amyloid A was considerably higher in horses that underwent elective and non-elective surgeries. For example, 24 hours after elective surgery, the average peak concentration was 16.4 microg/ml, and after non-elective surgery, it was 27.3 microg/ml.
  • Contrastingly, the control group of healthy horses had almost negligible levels of this protein, staying within the range of 0 to 0.2 microg/ml.

Serum Concentrations of Haptoglobin and Fibrinogen

  • The serum concentration levels of haptoglobin and fibrinogen increased gradually following surgery and remained elevated even 72 hours after surgery.
  • Unlike serum amyloid A, both haptoglobin and fibrinogen did not see a rapid and repeatable increase.

Implications of the Findings

  • The research indicates a substantial acute phase response in horses that have undergone surgery, as evidenced by increased serum concentrations of serum amyloid A, haptoglobin and fibrinogen.
  • The findings suggest that surgery, irrespective of being elective or non-elective, induces an inflammatory response in horses, which is reflected by significant changes in these proteins levels.
  • This study provides valuable insights that can contribute to the understanding of surgery-related inflammatory responses in horses and could potentially be used to enhance preoperative and postoperative care.

Cite This Article

APA
Pollock PJ, Prendergast M, Schumacher J, Bellenger CR. (2005). Effects of surgery on the acute phase response in clinically normal and diseased horses. Vet Rec, 156(17), 538-542. https://doi.org/10.1136/vr.156.17.538

Publication

The Veterinary record
ISSN: 0042-4900
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 156
Issue: 17
Pages: 538-542

Researcher Affiliations

Pollock, P J
  • Department of Veterinary Surgery, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland.
Prendergast, M
    Schumacher, J
      Bellenger, C R

        MeSH Terms

        • Acute-Phase Reaction / blood
        • Acute-Phase Reaction / veterinary
        • Animals
        • Elective Surgical Procedures / veterinary
        • Female
        • Fibrinogen / metabolism
        • Haptoglobins / metabolism
        • Hemoglobins
        • Horse Diseases / blood
        • Horse Diseases / surgery
        • Horses / blood
        • Horses / surgery
        • Male
        • Serum Amyloid A Protein / metabolism
        • Surgical Procedures, Operative / veterinary

        Citations

        This article has been cited 29 times.
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