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Home / Equine Research Bank / Aust Vet J / Effects of topical treatment of cannabidiol extract in a uni...
Australian veterinary journal2020; 98(6); 250-255; doi: 10.1111/avj.12932

Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study.

Abstract: Evaluate the effect of topical 1% cannabidiol on second intention wound healing in distal limb wounds of horses. Methods: Experimental. Methods: Six Standardbred horses. Methods: A total of five 2.5 cm × 2.5 cm full thickness skin wounds were created on the dorsomedial aspect of the metacarpi of 6 horses. Wounds were contaminated with faeces on the day of wound creation. Each wound was then assigned to a treatment group; compounded 1% cannabidiol in unique manuka factor (UMF) 5 manuka honey, UMF 5 manuka honey, UMF 20 manuka honey or saline. Each treatment was applied topically daily for a total of 42 days. Legs were bandaged and bandages were changed, daily, for 13 days postoperatively. Digital photographs of each wound were taken on day 1 then weekly for 6 weeks. Wound size, daily healing rate and total time to healing were recorded and compared statistically. Results: Irrespective of the treatment, wounds did not retract as expected in the first 7 days after wound creation. There was no difference in wound area, daily healing rate, days to complete healing between treatment groups. Conclusions: This preliminary study failed to demonstrate any difference in wound healing variables between treatment groups in this model of second intention wound healing. This was unexpected due to the established effects of UMF 20 manuka honey on wound healing using the same model. This may be due to systemic effects of cannabidiol and study design. Further research into the use of cannabidiol in equine wounds is warranted.
© 2020 Australian Veterinary Association.
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Publication Date: 2020-02-24 PubMed ID: 32096215DOI: 10.1111/avj.12932Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The abstract discusses a preliminary investigation that examined the effect of 1% cannabidiol in a manuka honey carrier on the healing of horses’ leg wounds. The results, however, didn’t show any notable difference in healing rates between various treatment groups.

Research Design and Participants

  • The study used an experimental approach and was conducted on six Standardbred horses.
  • The researchers created a total of five 2.5cm x 2.5cm full thickness skin wounds on the dorsomedial aspect (the upper, inner surface) of the metacarpi (the part of a horse’s leg equivalent to the human hand and fingers) of each horse.
  • To mimic real-world conditions where wounds might not be entirely clean, the wounds were intentionally contaminated with faeces on the day they were made.

Methods and Treatments

  • The wounds were sorted into treatment groups, each of which was assigned a different treatment: 1% cannabidiol mixed with UMF 5 manuka honey, UMF 5 manuka honey alone, UMF 20 manuka honey alone, and saline.
  • The chosen treatment was applied topically to the wounds every day for 42 days.
  • The horses’ legs were bandaged and the bandages changed daily for the first 13 days after the operation.
  • For measurement and monitoring purposes, digital photos were taken of all the wounds on the first day and then weekly for six weeks.

Measurements and Comparison

  • The researchers noted wound size, daily healing rate, and the total time needed for complete healing.
  • The treatments were compared statistically to observe any differences in wound healing periods or efficiency.

Results and Conclusion

  • Regardless of the treatment given, the researchers found that all wounds did not retract as expected within the first week of wound creation.
  • The study found no difference in wound area, daily healing rate, or the total time to complete healing between the different treatment groups, contrary to their expectations given the recognized effects of UMF 20 manuka honey on wound healing.
  • The initial analysis could not establish any significant variability in wound healing factors among the treatment groups using this model of second intention wound healing.
  • The researchers suggest that the lack of observable difference might be due to the systemic effects of cannabidiol and the design of the study.
  • They conclude that further research is needed to explore the potential benefits and effectiveness of using cannabidiol for equine wound treatment.

Cite This Article

APA
McIver VC, Tsang AS, Symonds NE, Perkins NR, Uquillas E, Dart CM, Jeffcott LB, Dart AJ. (2020). Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study. Aust Vet J, 98(6), 250-255. https://doi.org/10.1111/avj.12932

Publication

Australian veterinary journal
ISSN: 1751-0813
NlmUniqueID: 0370616
Country: England
Language: English
Volume: 98
Issue: 6
Pages: 250-255

Researcher Affiliations

McIver, V C
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.
Tsang, A S
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.
Symonds, N E
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.
Perkins, N R
  • School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland, Australia.
Uquillas, E
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.
Dart, C M
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.
Jeffcott, L B
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.
Dart, A J
  • Research and Clinical Training Unit, University Veterinary Teaching Hospital, The University of Sydney, Camden, New South Wales, Australia.

MeSH Terms

  • Animals
  • Cannabidiol
  • Factor V
  • Honey
  • Horses
  • Intention
  • Plant Extracts
  • Wound Healing

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