Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model.
Abstract: The objective of this study was to determine the effects of intra-articularly administered triamcinolone acetonide (TA) in exercised equine athletes with carpal osteochondral fragmentation. Eighteen horses were randomly assigned to each of 3 groups. An osteochondral chip fragment was created in one randomly chosen intercarpal joint of each horse. Both intercarpal joints in the placebo control group (CNT) horses were injected with intra-articular administration (IA) of polyionic fluid. Both joints in the TA control group (TA CNT) horses were treated with 12 mg of TA in the intercarpal joint without an osteochondral fragment, and the opposite intercarpal joint was injected with a similar volume of polyionic fluid. The TA treated group (TA TX) horses were treated with 12 mg of TA in the joint that contained the osteochondral fragment and the opposite intercarpal joint was injected with a similar volume of polyionic fluid. All horses were treated IA on days 13 and 27 after surgery and exercised on a high speed treadmill for 6 weeks starting on Day 14. Horses in the TA TX group were significantly less lame than horses in the CNT and TA CNT groups. Horses in either TA CNT or TA TX groups had lower total protein, and higher hyaluronan, and glycosaminoglycan concentrations in synovial fluid than did those in the CNT group. Synovial membrane collected from subjects in TA CNT and TA TX groups had significantly less inflammatory cell infiltration, subintimal hyperplasia and subintimal fibrosis compared to the CNT group. Articular cartilage histomorphological parameters were significantly better from the TA CNT and TA TX groups compared to the CNT group. In conclusions, results from this study support favourable effects of TA on degree of clinically detectable lameness, and on synovial fluid, synovial membrane, and articular cartilage morphological parameters, both with direct intra-articular administration and remote site administration as compared to placebo treatment. The clinical use of IA administered TA in horses may be therapeutically beneficial in selected cases of osteochondral fragmentation and osteoarthritis.
Publication Date: 1997-11-05 PubMed ID: 9306060DOI: 10.1111/j.2042-3306.1997.tb03138.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research article discusses the impact of triamcinolone acetonide (TA), when administered intra-articularly, on horses with carpal osteochondral fragmentation who are also undergoing exercise. The study suggests that the use of TA could be therapeutically beneficial in certain instances of osteochondral fragmentation and osteoarthritis.
Research Methodology
- The study included 18 horses that were split randomly into three groups.
- In each horse, an osteochondral chip fragment was intentionally established in one of the intercarpal joints, chosen at random.
- In the control group (CNT), both intercarpal joints were treated with an intra-articular injection of polyionic fluid.
- For horses in the TA control group (TA CNT), one joint – which didn’t have the osteochondral fragment – was injected with 12 mg of TA, and the other was treated with a similar amount of the polyionic fluid.
- The TA treated group (TA TX) comprised horses which had 12 mg of TA administered into the intercarpal joint containing the fragment, while the other joint received a similar volume of polyionic fluid.
- All horses had treatments administered on days 13 and 27 after surgery and commenced a six-week high-speed treadmill exercise from day 14 onwards.
Research Findings
- Horses in the TA TX group exhibited significantly less lameness compared to the CNT and TA CNT groups.
- The total protein was lower, while hyaluronan and glycosaminoglycan concentrations in the synovial fluid were higher in horses from either the TA CNT or TA groups than those in the CNT group.
- A lower rate of inflammatory cell infiltration, subintimal hyperplasia, and subintimal fibrosis were observed in the synovial membrane collected from those in TA CNT and TA TX groups compared to the CNT group.
- Articular cartilage histomorphological parameters were significantly improved in the TA CNT and TA TX groups compared to the CNT group.
Conclusion
- The findings from the study support the beneficial effects of TA in reducing clinically detectable lameness, and improving synovial fluid, synovial membrane, and articular cartilage morphological parameters, with both direct intra-articular administration and remote site administration.
- These results suggest that intra-articularly administered TA could be a potential therapeutic aid for certain cases of osteochondral fragmentation and osteoarthritis in horses.
Cite This Article
APA
Frisbie DD, Kawcak CE, Trotter GW, Powers BE, Walton RM, McIlwraith CW.
(1997).
Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model.
Equine Vet J, 29(5), 349-359.
https://doi.org/10.1111/j.2042-3306.1997.tb03138.x Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
MeSH Terms
- Animals
- Anti-Inflammatory Agents / administration & dosage
- Anti-Inflammatory Agents / pharmacology
- Cartilage Diseases / drug therapy
- Cartilage Diseases / etiology
- Cartilage Diseases / veterinary
- Cartilage, Articular / chemistry
- Cartilage, Articular / drug effects
- Cartilage, Articular / injuries
- Glycosaminoglycans / analysis
- Glycosaminoglycans / metabolism
- Horse Diseases / drug therapy
- Horse Diseases / etiology
- Horse Diseases / metabolism
- Horses / injuries
- Horses / metabolism
- Horses / physiology
- Hyaluronic Acid / analysis
- Hyaluronic Acid / metabolism
- Hyperplasia / drug therapy
- Hyperplasia / etiology
- Hyperplasia / veterinary
- Injections, Intra-Articular / methods
- Injections, Intra-Articular / veterinary
- Physical Conditioning, Animal / adverse effects
- Physical Conditioning, Animal / physiology
- Synovial Fluid / chemistry
- Synovial Fluid / drug effects
- Synovial Fluid / metabolism
- Synovial Membrane / chemistry
- Synovial Membrane / drug effects
- Synovial Membrane / metabolism
- Triamcinolone Acetonide / administration & dosage
- Triamcinolone Acetonide / pharmacology
Citations
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