Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease.
Abstract: Effects of triamcinolone acetonide (TA) on pulmonary function, bronchoalveolar lavage cytologic features and serum cortisol concentration, were studied in 5 control horses and 5 horses with chronic obstructive pulmonary disease (COPD). In experiment 1, horses were brought in from pasture 3 weeks before administration of 1 injection of TA (0.09 mg/kg of body weight, IM), and were stabled in dusty conditions throughout the experimental period. Measurements of respiratory rate (f), tidal volume, minute ventilation, expiratory-to-inspiratory time ratio, maximal change in transpulmonary pressure (delta PL), pulmonary resistance (RL), and dynamic compliance (Cdyn) were obtained during quiet breathing, immediately before (baseline) and 1, 2, 3, 5, and 9 weeks after administration of TA. Pulmonary airway cells were collected by bronchoalveolar lavage while horses were at pasture, at baseline, and 2, 5, and 9 weeks after TA administration. Serum cortisol concentration was measured before and after adrenocortical stimulation with 100 IU of adrenocorticotropic hormone, 1 week prior to TA administration, and 4 and 8 weeks thereafter. In experiment 2, 4 months after TA injection, pulmonary function measurements were repeated in all horses immediately before and 30 minutes after administration of atropine (0.015 mg/kg, IV), to evaluate the reversibility of airway obstruction. In experiment 1 at baseline, COPD-affected horses had significantly (P < 0.05) higher values than did controls for f, delta PL, RL, and percentage of neutrophils, and had lower values for Cdyn and percentage of lymphocytes and macrophages. There was significant reductions in delta PL and RL, and increase in macrophage percentage after TA administration in COPD-affected horses only.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1993-08-01 PubMed ID: 8214902
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research examines the impact of triamcinolone acetonide (TA) on the pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease (COPD). The findings suggest that TA administration resulted in significant improvements in the lung function of COPD-affected horses.
Introduction and Objectives
- This study aims to investigate the influence of triamcinolone acetonide (TA) on the pulmonary function, bronchoalveolar lavage cytologic features, and serum cortisol concentration in horses.
- The research involves two groups: control horses and horses suffering from chronic obstructive pulmonary disease (COPD).
Materials and Methods
- Ten horses were divided into two groups: five healthy control horses and five with COPD.
- Three weeks prior to the experiment, all horses were taken from pasture and moved into stabled, dusty conditions.
- TA was administered to the horses, after which various respiratory measurements were taken over a period of nine weeks.
- In addition, bronchoalveolar lavage was conducted to collect pulmonary airway cells, and serum cortisol concentration was measured.
- In a second experiment, testing was repeated four months after the TA administration to evaluate the persisting effects of the drug.
Results and Discussion
- Baseline measurements revealed that COPD-affected horses had significantly higher respiratory rate, transpulmonary pressure changes, pulmonary resistance, and neutrophil percentages compared to the control group.
- Conversely, COPD-affected horses had lower values for dynamic lung compliance and percentages of lymphocytes and macrophages.
- Following TA administration, significant reductions in transpulmonary pressure changes and pulmonary resistance were found, along with an increase in macrophage percentage, but only in the COPD-affected horses.
Conclusion
- The study thus indicates that TA administration significantly influences pulmonary function in horses with COPD, leading to improvements in lung function.
- More research is needed to further examine the safety and efficacy of triamcinolone acetonide in managing COPD in horses.
Cite This Article
APA
Lapointe JM, Lavoie JP, Vrins AA.
(1993).
Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease.
Am J Vet Res, 54(8), 1310-1316.
Publication
Researcher Affiliations
- Department of Medicine, Faculty of Veterinary Medicine, University of Montréal, St-Hyacinthe, Québec, Canada.
MeSH Terms
- Animals
- Bronchoalveolar Lavage Fluid / cytology
- Female
- Horse Diseases / drug therapy
- Horses
- Hydrocortisone / blood
- Lung Diseases, Obstructive / drug therapy
- Lung Diseases, Obstructive / veterinary
- Lymphocytes / drug effects
- Male
- Phagocytes / drug effects
- Respiration / drug effects
- Respiratory Function Tests / veterinary
- Triamcinolone Acetonide / therapeutic use
Citations
This article has been cited 7 times.- Mainguy-Seers S, Lavoie JP. Glucocorticoid treatment in horses with asthma: A narrative review.. J Vet Intern Med 2021 Jul;35(4):2045-2057.
- Pirie RS, Mueller HW, Engel O, Albrecht B, von Salis-Soglio M. Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial.. Equine Vet J 2021 Nov;53(6):1094-1104.
- Manguin E, Pépin E, Boivin R, Leclere M. Tracheal microbial populations in horses with moderate asthma.. J Vet Intern Med 2020 Mar;34(2):986-995.
- Bond S, Léguillette R, Richard EA, Couetil L, Lavoie JP, Martin JG, Pirie RS. Equine asthma: Integrative biologic relevance of a recently proposed nomenclature.. J Vet Intern Med 2018 Nov;32(6):2088-2098.
- Lavoie JP, Leclere M, Rodrigues N, Lemos KR, Bourzac C, Lefebvre-Lavoie J, Beauchamp G, Albrecht B. Efficacy of inhaled budesonide for the treatment of severe equine asthma.. Equine Vet J 2019 May;51(3):401-407.
- Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ. Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease.. J Vet Intern Med 2017 Jul;31(4):1193-1201.
- Couëtil LL, Cardwell JM, Gerber V, Lavoie JP, Léguillette R, Richard EA. Inflammatory Airway Disease of Horses--Revised Consensus Statement.. J Vet Intern Med 2016 Mar-Apr;30(2):503-15.
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