Efficacy of a morantel-abamectin combination for the treatment of resistant ascarids in foals.
Abstract: This study was performed to investigate the efficacy of a morantel-abamectin combination for the treatment of macrocyclic lactone (ML)-resistant Parascaris spp. infections in foals. Methods: Foals on five properties with a Parascaris faecal egg count (FEC) > 50 eggs per gram were used to estimate the FEC reduction (FECR) and efficacy of the anthelmintic combination. Conclusions: On all properties, resistance to ivermectin and abamectin was present and the Parascaris FECR in foals administered the morantel-abamectin combination was > 99%, indicating that this combination effectively controlled ML-resistant parasites.
© 2017 Australian Veterinary Association.
Publication Date: 2017-02-28 PubMed ID: 28239856DOI: 10.1111/avj.12559Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The research investigates how effective combining morantel and abamectin is in treating worm infections in young horses that are resistant to other typical treatments. The study found the combination to be over 99% efficient in all inspected properties, indicating it controls such resistant parasites effectively.
Methods of Research
The researchers utilised following methods in the study:
- They selected foals from five individual properties where the presence of Parasitic faecal egg count (Pro-Ascaris) was greater than 50 eggs per gram of faeces.
- They then calculated the reduction in faecal egg count (FECR) and the efficacy of the combination of morantel and abamectin as a de-wormer.
Findings of the Research
The findings from this study include:
- Resistance to commonly used de-worming agents, ivermectin and abamectin, was observed across all the properties.
- The use of a combo treatment: morantel-abamectin, resulted in a massive reduction in Parasitic faecal egg count (greater than 99%), indicating its effectiveness against worms that show resistance to the conventional treatments.
Conclusions of the study
Upon analyzing the data, the researchers concluded the following:
- The combination of morantel-abamectin has been highly effective against the macrocyclic lactone (ML)- resistant Parascaris spp. infections in foals.
- The efficiency of this combination treatment was consistent in all the properties they examined, suggesting that it is generally effective in controlling ML-resistant worms.
- This suggests that combining morantel and abamectin could be a viable alternative treatment for foals where the worms present resistance to traditional de-wormer medication.
Cite This Article
APA
Wilkes E, McConaghy FF, Thompson RL, Dawson K, Sangster NC, Hughes KJ.
(2017).
Efficacy of a morantel-abamectin combination for the treatment of resistant ascarids in foals.
Aust Vet J, 95(3), 85-88.
https://doi.org/10.1111/avj.12559 Publication
Researcher Affiliations
- School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
- Ceva Animal Health Pty Ltd, Glenorie, NSW, Australia.
- School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
- Dawbuts Pty Ltd, Camden, NSW, Australia.
- School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
- School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
MeSH Terms
- Animals
- Antinematodal Agents / administration & dosage
- Antinematodal Agents / therapeutic use
- Ascaridida Infections / drug therapy
- Ascaridida Infections / parasitology
- Ascaridida Infections / veterinary
- Ascaridoidea / drug effects
- Drug Combinations
- Drug Resistance
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horses / parasitology
- Ivermectin / administration & dosage
- Ivermectin / analogs & derivatives
- Ivermectin / therapeutic use
- Morantel / administration & dosage
- Morantel / therapeutic use
- Treatment Outcome
Citations
This article has been cited 7 times.- Cain JL, Norris JK, Ripley NE, Suri P, Finnerty CA, Gravatte HS, Nielsen MK. The microbial community associated with Parascaris spp. infecting juvenile horses. Parasit Vectors 2022 Nov 4;15(1):408.
- Cain JL, Nielsen MK. The equine ascarids: resuscitating historic model organisms for modern purposes. Parasitol Res 2022 Oct;121(10):2775-2791.
- Scare JA, Leathwick DM, Sauermann CW, Lyons ET, Steuer AE, Jones BA, Clark M, Nielsen MK. Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins. Int J Parasitol Drugs Drug Resist 2020 Apr;12:28-34.
- Saeed MA, Beveridge I, Abbas G, Beasley A, Bauquier J, Wilkes E, Jacobson C, Hughes KJ, El-Hage C, O'Handley R, Hurley J, Cudmore L, Carrigan P, Walter L, Tennent-Brown B, Nielsen MK, Jabbar A. Systematic review of gastrointestinal nematodes of horses from Australia. Parasit Vectors 2019 Apr 29;12(1):188.
- Abbas G, Nielsen MK, E-Hage C, Ghafar A, Beveridge I, Bauquier J, Beasley A, Wilkes EJA, Carrigan P, Cudmore L, Jacobson C, Hughes KJ, Jabbar A. Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions. Int J Parasitol Drugs Drug Resist 2025 Dec;29:100622.
- Abbas G, Stevenson MA, Bauquier J, Beasley A, Jacobson C, El-Hage C, Wilkes EJA, Carrigan P, Cudmore L, Hurley J, Beveridge I, Nielsen MK, Hughes KJ, Jabbar A. Assessment of worm control practices recommended by equine veterinarians in Australia. Front Vet Sci 2023;10:1305360.
- Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
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