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Home / Equine Research Bank / Equine Vet J / Efficacy of inhaled budesonide for the treatment of severe e...
Equine veterinary journal2018; 51(3); 401-407; doi: 10.1111/evj.13018

Efficacy of inhaled budesonide for the treatment of severe equine asthma.

Abstract: Corticosteroids are the most potent drugs for the control of severe equine asthma, but adverse effects limit their chronic systemic administration. Inhaled medications allow for drug delivery directly into the airways, reducing the harmful effects of these drugs. Objective: To evaluate the efficacy of inhaled budesonide specifically formulated for the equine use and administered by a novel inhalation device in horses with severe asthma. Methods: Experimental studies in horses with naturally occurring asthma with cross-over, randomised, blinded experimental designs. Methods: In Study 1, budesonide (1800 μg twice daily) administered using a novel Respimat based inhaler was compared to i.v. dexamethasone (0.04 mg/kg). In Study 2, 3 doses of budesonide (450, 900, and 1800 μg) were compared to oral dexamethasone (0.066 mg/kg). Lung function, bronchoalveolar fluid cytology (Study 1), CBC, serum chemistry, and serum cortisol and adrenocorticotropic hormone (ACTH) values were evaluated. Results: In Study 1, there was a marked and significant improvement in the lung function of all horses treated with budesonide and dexamethasone. Neutrophil percentages in bronchoalveolar fluid decreased in all horses treated with dexamethasone and in four of six horses treated with budesonide. Serum cortisol and blood ACTH concentrations decreased with both treatments. In Study 2, there was a significant improvement in the lung function with all dosages of budesonide, and the effects of higher dosages were comparable to those of dexamethasone. Dexamethasone and budesonide at the two higher dosages induced a significant decrease of cortisol concentrations. Conclusions: The Respimat based inhaler is not currently commercially available. Conclusions: Administration of budesonide with the Respimat based inhaler provided dose-dependent relief of airway obstruction in horses with severe asthma, but also a suppression of serum cortisol.
© 2018 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
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Publication Date: 2018-09-25 PubMed ID: 30203854PubMed Central: PMC6585971DOI: 10.1111/evj.13018Google Scholar: Lookup
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  • Clinical Trial
  • Veterinary
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research scrutinizes the efficacy of using inhaled budesonide to treat severe equine asthma. Budesonide was compared with common corticosteroids in its ability to improve lung function while mitigating adverse effects.

Objective and Methodology

  • The primary objective of the study was to investigate the effectiveness of inhaled budesonide, specifically formulated for equines and dispensed with a new Respimat based inhaler, in treating severe asthma in horses.
  • The approach employed experimental studies on horses suffering from natural asthma. The studies followed cross-over, randomized, and blinded experimental designs.
  • Two studies were conducted. In Study 1, budesonide, administered with the Respimat inhaler, was compared to intravenous dexamethasone. In Study 2, budesonide was compared to oral dexamethasone but with varying doses of budesonide.
  • Different analyses were performed which included evaluation of lung function, bronchoalveolar fluid cytology, complete blood count, serum chemistry, and serum cortisol and adrenocorticotropic hormone (ACTH) values.

Findings of the Study

  • Study 1 revealed a substantial improvement in lung function of horses treated with both budesonide and dexamethasone. Furthermore, the percentage of neutrophils in bronchoalveolar fluid decreased in all horses treated with dexamethasone and in four of six horses treated with budesonide. Blood ACTH and serum cortisol concentrations also decreased with both treatments.
  • Study 2 suggested significant improvement of lung function across all dosages of budesonide, with the effects of high dosages demonstrating comparability to dexamethasone. Both dexamethasone and high-dose budesonide caused a significant reduction in cortisol concentrations.

Conclusions

  • The Respimat based inhaler, although it is not currently commercially available, proved viable for the administration of budesonide.
  • Inhaled budesonide provided dose-dependent relief from airway obstruction in horses suffering from severe asthma. However, the treatment also suppressed serum cortisol.

Implications

  • This research demonstrates the potential of inhaled budesonide as a viable treatment for severe equine asthma. It helps reduce obstruction in the airways, improving airflow and thus, their lung function.
  • While budesonide shows promising results, it’s effect on serum cortisol indicates a need to monitor potential side effects during use. This can ensure that the benefits do not come at the expense of causing other problems in the treated animals.

Cite This Article

APA
Lavoie JP, Leclere M, Rodrigues N, Lemos KR, Bourzac C, Lefebvre-Lavoie J, Beauchamp G, Albrecht B. (2018). Efficacy of inhaled budesonide for the treatment of severe equine asthma. Equine Vet J, 51(3), 401-407. https://doi.org/10.1111/evj.13018

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 51
Issue: 3
Pages: 401-407

Researcher Affiliations

Lavoie, J P
  • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Leclere, M
  • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Rodrigues, N
  • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Lemos, K R
  • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Bourzac, C
  • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Lefebvre-Lavoie, J
  • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Beauchamp, G
  • Department of Veterinary Biomedicine, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Q, Canada.
Albrecht, B
  • Boehringer Ingelheim Vetmedica GmbH, Ingelheim am Rhein, Germany.

MeSH Terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use
  • Asthma / drug therapy
  • Asthma / veterinary
  • Budesonide / administration & dosage
  • Budesonide / therapeutic use
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Horse Diseases / drug therapy
  • Horses
  • Random Allocation

Grant Funding

  • Boehringer Ingelheim Vetmedica GmbH

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Citations

This article has been cited 8 times.
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