Efficacy of intrauterine infusion of plasma for treatment of infertility and endometritis in mares.
Abstract: We evaluated the efficacy of intrauterine plasma infusion in mares as a treatment for infertility caused by endometritis and distinguished the effects of intrauterine infusion of plasma vs saline solution. Forty-three subfertile mares were randomly assigned to 1 of 3 treatment groups: untreated controls (n = 14), those treated by saline infusion (n = 14), and those treated by plasma infusion (n = 15). Reproductive status was assessed daily by transrectal ultrasonography. Uterine aspirates and biopsy specimens were obtained 8 days after ovulation for cytologic and histologic evaluation, and mares were treated on days 12 to 16. Uterine aspirates and biopsy specimens were obtained again on day 8 of the next estrous cycle, and the mares were bred at the subsequent estrus. A postovulation intrauterine infusion of either plasma or saline solution was administered to mares in their respective treatment groups. Biopsy specimens were scored from 1 (no indications of inflammation) to 6 (severe inflammation). The pregnancy rate was lower (P less than 0.005) for mares with scores 5 and 6 (0/5) than for those with scores 1 to 4 (17/35). There was no significant effect of treatment nor a treatment by biopsy score interaction on pregnancy rate; however, the pregnancy rate for mares treated with plasma or saline solution (9/27) tended to be lower than for the control (untreated) mares (8/13). There was no change in mean biopsy score between specimens obtained before treatment and those obtained after treatment for the control group and the group treated with saline solution; however, there was a significant increase (P less than 0.05) in scores in the group treated with plasma.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1989-02-01 PubMed ID: 2917906
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article evaluates the effectiveness of injecting plasma directly into the uterus of mares as a treatment for infertility resulting from endometritis. It compares the results of this treatment to that of a saline solution infusion and an untreated control group.
Study Design
- The research involved 43 subfertile mares, who were randomly assigned to one of three groups: an untreated control group, a saline solution infusion group, and a plasma infusion group.
- The reproductive status of the mares was checked daily via transrectal ultrasonography.
- Both uterine samples and biopsy specimens were collected eight days after ovulation for examination before the treatments were administered between days 12 to 16 of the cycle.
- All mares were bred at the next estrus, and a post-ovulation intrauterine infusion was given to the mares in the saline and plasma treatment groups.
Scoring and Results
- The biopsy specimens were scored from 1 to 6, ranging from no inflammation (1) to severe inflammation (6), to evaluate the progress of the treatment.
- Statistical analysis showed a significantly lower pregnancy rate in mares with a biopsy score of 5 and 6, representing severe inflammation.
- While no significant effect of either treatment on the pregnancy rate was observed, the researchers noted that the pregnancy rate tended to be lower in mares treated with plasma or saline solution than in the control group.
Treatment Effect on Biopsy Score
- No significant change in the biopsy scores was observed between the pre-treatment and post-treatment specimens for both the control group and the saline treatment group.
- Interestingly, there was a significant increase in biopsy scores for the plasma-treated group, indicating an increase in inflammation after plasma infusion treatment.
Conclusion
- The study’s findings suggest that intrauterine plasma infusion did not prove effective as a treatment for endometritis-induced infertility in mares.
- Contrary to expectations, mares treated with plasma displayed a notable increase in endometrial inflammation.
Cite This Article
APA
Adams GP, Ginther OJ.
(1989).
Efficacy of intrauterine infusion of plasma for treatment of infertility and endometritis in mares.
J Am Vet Med Assoc, 194(3), 372-378.
Publication
Researcher Affiliations
- Department of Veterinary Science, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706.
MeSH Terms
- Animals
- Biopsy / veterinary
- Endometritis / therapy
- Endometritis / veterinary
- Female
- Fertility
- Horse Diseases / therapy
- Horses
- Infertility, Female / therapy
- Infertility, Female / veterinary
- Plasma
- Pregnancy
- Sodium Chloride / therapeutic use
- Uterus / pathology
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