Efficacy of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes.
Abstract: The efficacy of moxidectin 2 per cent equine gel against naturally acquired strongyle infections was assessed in 18 ponies which had grazed on contaminated pasture before being housed for eight weeks. Twenty-four hours before the treatment, two randomly selected ponies were euthanased and their worm burdens were determined. Eight of the remaining 16 ponies were treated with moxidectin 2 per cent gel while the other eight were given a placebo gel. Eight weeks later the 16 animals were necropsied and their worm burdens established. A 100 per cent efficacy was recorded against adult and lumenal L4 cyathostomes and adult Strongylus and Triodontophorus species. Digest recoveries of larval cyathostomes indicated a 90.8 per cent (P<0.002) reduction in early L3 and a 99.9 per cent (P<0.001) reduction in developing stages. There was a reduction in faecal egg output of between 96 and 100 per cent in the treated animals compared with the controls.
Publication Date: 2001-03-29 PubMed ID: 11271915DOI: 10.1136/vr.148.5.138Google Scholar: Lookup
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- Journal Article
Summary
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This research studied the effectiveness of a 2% moxidectin gel in treating horses for strongyle infections, particularly larval cyathostomes, showing high efficacy in reducing worm burdens and faecal egg output.
Research Background and Methodology
- The study aimed to assess the efficiency of 2% moxidectin gel against naturally acquired strongyle infections, a common type of parasitic worm found in horses.
- 18 ponies that previously grazed on contaminated pastures were used for the study. They were housed for eight weeks, simulating a controlled environment.
- Before starting the treatment, two randomly selected ponies were euthanized and their worm burdens were calculated to provide an initial comparative baseline.
Treatment Process
- Eight ponies were treated with a 2% moxidectin gel, while the other eight received a placebo gel as a control group.
- The study then continued for a further eight weeks, after which the 16 ponies were necropsied (a post-mortem examination) in order to measure and compare their worm burdens.
Study Findings
- The research found moxidectin gel to be 100% effective against adult and lumenal L4 cyathostomes and the adult stages of the Strongylus and Triodontophorus species, both types of horse parasites.
- Digest recovery results indicated a significant reduction in larval cyathostomes. Early L3 reductions were recorded at 90.8% (P<0.002) and the developing stages at 99.9% (P<0.001).
- Furthermore, the study recorded a reduction in faecal egg output, a measure of parasitic infestation, between 96 and 100% in treated animals compared to the control group, underscoring the effectiveness of the treatment.
Conclusion
- The research concluded that moxidectin 2% equine gel is highly effective against naturally acquired strongyle infections, particularly against larval cyathostomes.
- This result adds to the body of evidence supporting the use of moxidectin 2% gel in controlling and treating horse parasitic infections.
Cite This Article
APA
Bairden K, Brown SR, McGoldrick J, Parker LD, Talty PJ.
(2001).
Efficacy of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes.
Vet Rec, 148(5), 138-141.
https://doi.org/10.1136/vr.148.5.138 Publication
Researcher Affiliations
- Department of Veterinary Parasitology, University of Glasgow Veterinary School.
MeSH Terms
- Animals
- Anthelmintics / pharmacology
- Anthelmintics / therapeutic use
- Anti-Bacterial Agents / pharmacology
- Anti-Bacterial Agents / therapeutic use
- Feces / parasitology
- Female
- Horses
- Larva / drug effects
- Larva / growth & development
- Macrolides
- Male
- Strongyle Infections, Equine / drug therapy
- Strongyle Infections, Equine / parasitology
- Strongyloidea / drug effects
- Strongyloidea / growth & development
- Treatment Outcome
Citations
This article has been cited 4 times.- Abbas G, Ghafar A, Hurley J, Bauquier J, Beasley A, Wilkes EJA, Jacobson C, El-Hage C, Cudmore L, Carrigan P, Tennent-Brown B, Gauci CG, Nielsen MK, Hughes KJ, Beveridge I, Jabbar A. Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasit Vectors 2021 Dec 4;14(1):597.
- Elsener J, Villeneuve A. Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing. Can Vet J 2009 May;50(5):486-90.
- Lyons ET, Tolliver SC. Field test data on small strongyles in evaluation of activity of fenbendazole given once a day for 5 consecutive days to thoroughbred yearlings on two farms in Kentucky in 2002 and 2003. Parasitol Res 2003 Oct;91(4):312-5.
- Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
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