EHV-1-induced abortion in mice and its relationship to stage of gestation.
Abstract: The most important consequence of equine herpesvirus-1 (EHV-1) infection is abortion. The object of the present study was to characteristic further a murine EHV-1 abortion model and to make comparisons with the natural host with particular reference to the stage of gestation during which the infection occurs. BALB/c mice at different stages of pregnancy were infected intranasally with EHV-1 (strain AB4); they suffered respiratory distress, weight loss, and other constitutional signs of infection. When the virus was inoculated in the late second or early third week of gestation dead or dying fetuses were aborted, whereas infection between seven and nine days of pregnancy led to fetal death and resorption. During the process of resorption, complications were observed. Virus was frequently isolated from the placentas and occasionally from the tissues of the aborting fetuses, depending on the severity of the infection of the placentas. In some cases, therefore, the inoculation resulted in abortion although the infection was restricted to the placenta. Virus antigen was detected in the placentas, lungs and occasionally in other tissues of the aborting fetuses. The potential of this murine model for testing methods for the diagnosis and control of equine abortion is discussed.
Publication Date: 1995-09-01 PubMed ID: 8525103DOI: 10.1016/0034-5288(95)90048-9Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper discusses an experiment studying the effects of equine herpesvirus-1 (EHV-1) infections and their correlation to abortions during specific stages of gestation, conducted utilizing a murine model.
Overview of the EHV-1 Consequence
- This research examines the consequences of equine herpesvirus-1 (EHV-1) infection, with a particular focus on its most serious outcome, causing abortion in pregnant subjects.
Murine Model for EHV-1 Infection
- The researchers employed BALB/c mice as their model. The mice were at various stages of pregnancy and were infected with EHV-1 via intranasal means.
- Upon infection, the mice showed evident signs of respiratory distress, weight loss, and other signatures of an infection.
Impact on pregnancy related to Stage of Gestation
- The timing of the infection proved to be crucial in impacting the fate of the fetuses. When the virus was introduced in the later stages of the second week or in the early third week of gestation, it led to the abortion of dead or dying fetuses.
- In contrast, when the infection was carried out between the seventh and ninth days of gestation, it resulted in the death and subsequent resorption of the fetuses, sometimes with further complications.
Interaction of Virus with Placentas and Fetuses
- In their investigation, the researchers found the virus frequently present in the placentas and occasionally within the tissue of the aborted fetuses, dependent on the severity of the placental infection.
- In some cases, even though the infection was localized to the placenta, it still resulted in abortion.
Detection of Virus Antigens
- The detection of virus antigens was primarily found in the placentas and lungs. However, it was occasionally found in the tissues of the fetuses that aborted.
Potential Applications of the Model
- The researchers suggested that this murine model could have potential use in diagnosing and controlling equine abortion, by allowing for the testing of various methods.
Cite This Article
APA
Awan AR, Baxi M, Field HJ.
(1995).
EHV-1-induced abortion in mice and its relationship to stage of gestation.
Res Vet Sci, 59(2), 139-145.
https://doi.org/10.1016/0034-5288(95)90048-9 Publication
Researcher Affiliations
- Department of Clinical Veterinary Medicine, University of Cambridge.
MeSH Terms
- Abortion, Veterinary / virology
- Animals
- DNA, Viral / analysis
- Female
- Fetus / pathology
- Fetus / virology
- Gestational Age
- Herpesviridae Infections / embryology
- Herpesviridae Infections / pathology
- Herpesvirus 1, Equid / isolation & purification
- Horses
- In Situ Hybridization
- Mice
- Mice, Inbred BALB C
- Placenta / pathology
- Placenta / virology
- Pregnancy
Citations
This article has been cited 2 times.- Abas O, Abdo W, Kasem S, Alwazzan A, Saleh AG, Saleh IG, Fukushi H, Yanai T, Haridy M. Time Course-Dependent Study on Equine Herpes Virus 9-Induced Abortion in Syrian Hamsters. Animals (Basel) 2020 Aug 7;10(8).
- Buendía AJ, Sánchez J, Martínez MC, Cámara P, Navarro JA, Rodolakis A, Salinas J. Kinetics of infection and effects on placental cell populations in a murine model of Chlamydia psittaci-induced abortion. Infect Immun 1998 May;66(5):2128-34.
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