Journal of veterinary internal medicine2008; 22(4); 826-831; doi: 10.1111/j.1939-1676.2008.0117.x

Electrochemotherapy in veterinary oncology.

Cemazar, M
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Tamzali, Y
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Sersa, G
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Tozon, N
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Mir, LM
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Miklavcic, D
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Lowe, R
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Teissie, J

Abstract: Electropermeabilization is a method that uses electric field pulses to induce an electrically mediated reorganization of the plasma membrane of cells. Electrochemotherapy combines local or systemic administration of chemotherapeutic drugs such as bleomycin or cisplatin that have poor membrane permeability with electropermeabilization by direct application of electric pulses to the tumors. Preclinical studies have demonstrated excellent antitumor effectiveness of electrochemotherapy on different animal models and various tumor types, minimal toxicity, and safety of the procedure. Based on results of preclinical studies, clinical studies were conducted in human patients, which demonstrated pronounced antitumor effectiveness of electrochemotherapy with 80-85% objective responses of the treated cutaneous and SC tumors. Clinical studies in veterinary oncology have demonstrated that electrochemotherapy is very effective in the treatment of cutaneous and SC tumors of different histologic types in cats, dogs, and horses. The results of these studies have also demonstrated approximately 80% long-lasting objective responses of tumors treated by electrochemotherapy. Primary tumors of different histologic types were treated. Electrochemotherapy in veterinary oncology has future promise to be highly effective, and could be used to treat primary or recurrent solitary or multiple cutaneous and SC tumors of different histology or as an adjuvant treatment to surgery.

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Publication Date: 2008-06-10 PubMed ID: 18537879DOI: 10.1111/j.1939-1676.2008.0117.xGoogle Scholar: Lookup

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This research article presents a study on the effectiveness of electrochemotherapy, a method that combines chemotherapy with electricity, for the treatment of tumors in animals. The study found that electrochemotherapy, when used to treat various tumor types in cats, dogs, and horses, showed promising results, with around 80% long-lasting responses and minimal toxicity, indicating that it could potentially be a highly effective treatment method in veterinary oncology.

Understanding Electrochemotherapy

Electrochemotherapy is a treatment method that combines the use of chemotherapeutic drugs with electropermeabilization, a procedure that involves the use of electric fields to rearrange the cells’ plasma membrane. This facilitates the entry of the chemotherapeutic drugs, which normally have poor membrane permeability, into the cells.
This technique is particularly used with drugs such as bleomycin or cisplatin, which are typically used in chemotherapy. The electric pulses are directly applied to the tumors.

Preclinical and Clinical Studies

The article highlights that preclinical studies on different animal models have shown that electrochemotherapy is extremely effective against various types of tumors, demonstrating minimal toxicity and safety of the procedure.
In addition to the preclinical studies, clinical studies were also conducted on human patients, which further corroborated the high efficacy of electrochemotherapy. Around 80-85% objective responses were observed in the treated cutaneous and subcutaneous (SC) tumors.