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Home / Equine Research Bank / Open Vet J / Electrochemotherapy increases local control after incomplete...
Open veterinary journal2016; 6(3); 234-237; doi: 10.4314/ovj.v6i3.12

Electrochemotherapy increases local control after incomplete excision of a recurring penile fibrosarcoma in a stallion.

Abstract: An eleven-year-old stallion was referred for adjuvant treatment of an incompletely excised, recurring penile fibrosarcoma. The horse was bright, alert and responsive with a 15 x 12 cm ulcerated lesion on the ventral side of the penis. The lesion was the tumor bed of an incompletely excised fibrosarcoma. After complete staging procedures, the owner elected to treat the horse with electrochemotherapy (ECT) using cisplatin as chemotherapy agent. Two sessions of ECT were performed at two-week intervals using local cisplatin followed by trains of biphasic electric pulses applied using different electrodes until complete coverage of the area was achieved. The treatment was well tolerated, and the patient is still disease free after 12 months. ECT resulted in improved local control and should be considered among the available adjuvant treatments in equines carrying soft tissue tumors.
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Publication Date: 2016-11-26 PubMed ID: 27995080PubMed Central: PMC5155137DOI: 10.4314/ovj.v6i3.12Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research features a successful case of treating a recurring penile fibrosarcoma in a stallion using Electrochemotherapy (ECT), resulting in the horse being disease-free for 12 months post-treatment.

Introduction

  • The study revolves around an eleven-year-old stallion who was brought in for additional treatment after the incomplete removal of a recurring penile fibrosarcoma, a form of cancerous tumor.
  • An ulcerated lesion, measuring 15 x 12 cm, was present on the underside of the penis. This lesion was the bed of the incompletely excised fibrosarcoma.

Treatment Methodology

  • After performing complete staging procedures, the owner decided to treat the horse with Electrochemotherapy (ECT) using cisplatin, a chemotherapy agent.
  • The ECT treatment involved two sessions that were spaced two weeks apart. Each session comprised the local administration of cisplatin followed by biphasic electric pulses.
  • Different electrodes were used throughout the treatment to ensure the full coverage of the area.

Results and Conclusion

  • The treatment was reported to be well tolerated by the stallion.
  • The patient remained disease-free after 12 months, demonstrating the effectiveness of ECT as a treatment option.
  • Based on the findings from this case, it was suggested that ECT be considered as one of the potential adjuvant treatments in equines carrying soft tissue tumors.

Significance of the Study

  • This study is significant as it presents ECT not just as a feasible but also as an effective therapeutic strategy for treating tumors in equines.
  • It provides an evidence-based recommendation for ECT as a promising adjuvant treatment for similar cases of fibrosarcoma in stallions.
  • The case study further helps to illuminate the potential of ECT and cisplatin in the field of equine oncology.

Cite This Article

APA
Spugnini EP, Bolaffio C, Scacco L, Baldi A. (2016). Electrochemotherapy increases local control after incomplete excision of a recurring penile fibrosarcoma in a stallion. Open Vet J, 6(3), 234-237. https://doi.org/10.4314/ovj.v6i3.12

Publication

Open veterinary journal
ISSN: 2226-4485
NlmUniqueID: 101653182
Country: Libya
Language: English
Volume: 6
Issue: 3
Pages: 234-237

Researcher Affiliations

Spugnini, E P
  • Biopulse S.r.l., Naples, Italy.
Bolaffio, C
  • Equivet Roma Hospital, Rome, Italy.
Scacco, L
  • Equivet Roma Hospital, Rome, Italy.
Baldi, A
  • Biopulse S.r.l., Naples, Italy; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Italy.

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Citations

This article has been cited 3 times.
  1. Spugnini EP, Scacco L, Bolaffio C, Baldi A. Electrochemotherapy for the treatment of cutaneous solid tumors in equids: A retrospective study. Open Vet J 2021 Jul-Sep;11(3):385-389.
    doi: 10.5455/OVJ.2021.v11.i3.8pubmed: 34722200google scholar: lookup
  2. Condello M, D'Avack G, Vona R, Spugnini EP, Scacco L, Meschini S. Electrochemotherapy with Mitomycin C Potentiates Apoptosis Death by Inhibiting Autophagy in Squamous Carcinoma Cells. Cancers (Basel) 2021 Jul 31;13(15).
    doi: 10.3390/cancers13153867pubmed: 34359775google scholar: lookup
  3. Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J 2017;7(2):192-196.
    doi: 10.4314/ovj.v7i2.18pubmed: 28717603google scholar: lookup
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