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The Veterinary clinics of North America. Equine practice2011; 27(1); 35-47; doi: 10.1016/j.cveq.2010.12.011

Endocrine dysregulation in critically ill foals and horses.

Abstract: Critical illness challenges many endocrine homeostatic systems to overcome diseases, stress, and hostile conditions that threaten survival. Coordinated and consecutive responses by the autonomic nervous system, endocrine metabolic adaptations to mobilize and conserve energy and electrolytes, cardiovascular adjustments to maintain organ perfusion, and immunomodulation to overcome infections and inflammation are required. Because most admissions to equine intensive care units are related to horses with gastrointestinal disease and septic foals, most endocrine information during critical disease are generated from these populations. This article presents an overview on endocrine responses to critical illness in horses and foals and also some comparative information.
Publication Date: 2011-03-12 PubMed ID: 21392652DOI: 10.1016/j.cveq.2010.12.011Google Scholar: Lookup
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Summary

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The article discusses the various endocrine system responses in critically ill horses and foals, particularly those with gastrointestinal diseases or sepsis, and provides a comparative analysis.

Endocrine Responses and Critical Illness

  • When a horse or foal is critically ill, there’s a considerable strain on the endocrine system. The body needs to maintain balance in response to disease, stress, and other potentially lethal conditions.
  • Many of the responses are based on the interaction of the autonomic nervous system and the endocrine system. These systems work to regulate energy and electrolyte use, keep blood flow to the organs stable, and modulate the immune response to control inflammation and infection.

Endocrine Studies on Critically Ill Equine

  • Most of the research on endocrine responses in critically ill horses and foals stems from those admitted to equine intensive care units with gastrointestinal diseases or sepsis.
  • The collected data is important because it helps to understand the complex relationships and interactions between the endocrine system and disease in these animals.

Comparative Information

  • The article also provides comparative information, giving context to the endocrine responses seen in horses and foals in critical conditions.
  • Such comparative studies are crucial in better understanding how different species’ bodies respond to critical illnesses and finding connection patterns that could lead to better treatment strategies.

Cite This Article

APA
Toribio RE. (2011). Endocrine dysregulation in critically ill foals and horses. Vet Clin North Am Equine Pract, 27(1), 35-47. https://doi.org/10.1016/j.cveq.2010.12.011

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 27
Issue: 1
Pages: 35-47

Researcher Affiliations

Toribio, Ramiro E
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp Street, Columbus, OH 43210, USA. toribio.1@osu.edu

MeSH Terms

  • Animals
  • Animals, Newborn
  • Critical Illness
  • Endocrine System Diseases / blood
  • Endocrine System Diseases / metabolism
  • Endocrine System Diseases / mortality
  • Endocrine System Diseases / veterinary
  • Female
  • Horse Diseases / blood
  • Horse Diseases / metabolism
  • Horse Diseases / mortality
  • Horses
  • Male
  • Prognosis
  • Sepsis / blood
  • Sepsis / metabolism
  • Sepsis / mortality
  • Sepsis / veterinary
  • Severity of Illness Index
  • Survival Analysis
  • Thyroid Hormones / blood
  • Water-Electrolyte Balance / physiology

Citations

This article has been cited 9 times.
  1. Ellero N, Lanci A, Baldassarro VA, Alastra G, Mariella J, Cescatti M, Castagnetti C, Giardino L. Study on NGF and VEGF during the Equine Perinatal Period-Part 2: Foals Affected by Neonatal Encephalopathy.. Vet Sci 2022 Aug 26;9(9).
    doi: 10.3390/vetsci9090459pubmed: 36136675google scholar: lookup
  2. Lanci A, Mariella J, Ellero N, Faoro A, Peric T, Prandi A, Freccero F, Castagnetti C. Hair Cortisol and DHEA-S in Foals and Mares as a Retrospective Picture of Feto-Maternal Relationship under Physiological and Pathological Conditions.. Animals (Basel) 2022 May 14;12(10).
    doi: 10.3390/ani12101266pubmed: 35625111google scholar: lookup
  3. Lauteri E, Mariella J, Beccati F, Roelfsema E, Castagnetti C, Pepe M, Peric T, Barbato O, Montillo M, Rouge S, Freccero F. Adrenal Gland Ultrasonographic Measurements and Plasma Hormone Concentrations in Clinically Healthy Newborn Thoroughbred and Standardbred Foals.. Animals (Basel) 2021 Jun 19;11(6).
    doi: 10.3390/ani11061832pubmed: 34205258google scholar: lookup
  4. Vitale V, Berg LC, Larsen BB, Hannesdottir A, Dybdahl Thomsen P, Laursen SH, Verwilghen D, van Galen G. Blood glucose and subcutaneous continuous glucose monitoring in critically ill horses: A pilot study.. PLoS One 2021;16(2):e0247561.
    doi: 10.1371/journal.pone.0247561pubmed: 33626099google scholar: lookup
  5. Swink JM, Rings LM, Snyder HA, McAuley RC, Burns TA, Dembek KA, Gilsenan WF, Browne N, Toribio RE. Dynamics of androgens in healthy and hospitalized newborn foals.. J Vet Intern Med 2021 Jan;35(1):538-549.
    doi: 10.1111/jvim.15974pubmed: 33277956google scholar: lookup
  6. Müller V, Toribio RE, Dembek K, Moraes BSS, Mousquer MA, Curcio BR, Nogueira CEW. Serum cortisol and thyroid hormone concentrations and survival in foals born from mares with experimentally induced ascending placentitis.. J Vet Intern Med 2020 May;34(3):1332-1338.
    doi: 10.1111/jvim.15758pubmed: 32339347google scholar: lookup
  7. Dembek KA, Johnson LM, Timko KJ, Minuto JS, Hart KA, Barr BS, Toribio RE. Multiple adrenocortical steroid response to administration of exogenous adrenocorticotropic hormone to hospitalized foals.. J Vet Intern Med 2019 Jul;33(4):1766-1774.
    doi: 10.1111/jvim.15527pubmed: 31111575google scholar: lookup
  8. Barton AK, Pelli A, Rieger M, Gehlen H. Procalcitonin as a biomarker in equine chronic pneumopathies.. BMC Vet Res 2016 Dec 9;12(1):281.
    doi: 10.1186/s12917-016-0912-4pubmed: 27938364google scholar: lookup
  9. Kamr AM, Dembek KA, Reed SM, Slovis NM, Zaghawa AA, Rosol TJ, Toribio RE. Vitamin D Metabolites and Their Association with Calcium, Phosphorus, and PTH Concentrations, Severity of Illness, and Mortality in Hospitalized Equine Neonates.. PLoS One 2015;10(6):e0127684.
    doi: 10.1371/journal.pone.0127684pubmed: 26046642google scholar: lookup