Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly.
Abstract: An unmet need remains for a bone graft substitute material that is biocompatible, biodegradable and capable of promoting osteogenesis safely in vivo. The aim of this study was to investigate the use of a novel collagen-hydroxyapatite (CHA) bone graft substitute in the clinical treatment of a mandibular bone cyst in a young horse and to assess its potential to enhance repair of the affected bone. A 2 year-old thoroughbred filly, presenting with a multilobulated aneurysmal bone cyst, was treated using the CHA scaffold. Post-operative clinical follow-up was carried out at 2 weeks and 3, 6 and 14 months. Cortical thickening in the affected area was observed from computed tomography (CT) examination as early as 3 months post-surgery. At 14 months, reduced enlargement of the operated mandible was observed, with no fluid-filled area. The expansile cavity was occupied by moderately dense mineralized tissue and fat and the compact bone was remodelled, with a clearer definition between cortex and medulla observed. This report demonstrates the promotion of enhanced bone repair following application of the CHA scaffold material in this craniomaxillofacial indication, and thus the potential of this material for translation to human applications.
Copyright © 2015 John Wiley & Sons, Ltd.
Publication Date: 2015-02-25 PubMed ID: 25712436DOI: 10.1002/term.2006Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study aimed to assess the effectiveness of a newly developed collagen-hydroxyapatite bone graft substitute for treating a bone cyst in a horse’s jaw. The results showed improved bone repair after using the substitute in surgery, suggesting its potential usefulness in human applications.
Research Objective
- The main goal of this study was to evaluate the efficiency of a novel collagen-hydroxyapatite (CHA) bone graft substitute for clinical treatment of a bone cyst in a horse’s jaw. The researchers were interested to see if this new graft substitute could promote better bone repair.
Methodology
- Using a 2-year-old thoroughbred filly suffering from a multilobulated aneurysmal bone cyst, the researchers implanted the CHA scaffold into the affected area.
- Post-operative check-ups were conducted at intervals of two weeks, three months, six months, and 14 months to assess the healing progress.
- A computed tomography (CT) examination allowed researchers to observe any changes in the affected area, including thickening or thinning of the cortical bone.
Results
- Three months after surgery, CT scans revealed cortical thickening in the treated area. By the 14-month mark, the researchers noted a decrease in enlargement of the operated jaw area, with no more fluid-filled region.
- The cavity initially occupied by the cyst was filled with moderately dense mineralized tissue and fat. The compact bone in the area appeared to have been remodelled, with a clearer definition seen between the cortex and medulla.
Conclusion
- In demonstrating the promotion of enhanced bone repair following the use of a CHA scaffold material, this study suggests the potential of this material for broader clinical use, including potentially for human applications.
Cite This Article
APA
David F, Levingstone TJ, Schneeweiss W, de Swarte M, Jahns H, Gleeson JP, O'Brien FJ.
(2015).
Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly.
J Tissue Eng Regen Med, 9(10), 1193-1199.
https://doi.org/10.1002/term.2006 Publication
Researcher Affiliations
- University College Dublin Veterinary Hospital, University College Dublin, Ireland.
- Mid-Atlantic Equine Medical Center, Ringoes, NJ, USA.
- Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.
- Trinity Centre for Bioengineering, Trinity College Dublin, Ireland.
- Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin, Ireland.
- University College Dublin Veterinary Hospital, University College Dublin, Ireland.
- Pferdeklinik Pegasus, Breitenfurt, Austria.
- University College Dublin Veterinary Hospital, University College Dublin, Ireland.
- University College Dublin Veterinary Hospital, University College Dublin, Ireland.
- Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.
- Trinity Centre for Bioengineering, Trinity College Dublin, Ireland.
- Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin, Ireland.
- SurgaColl Technologies Ltd, Invent, Dublin City University, Dublin, Ireland.
- Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.
- Trinity Centre for Bioengineering, Trinity College Dublin, Ireland.
- Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin, Ireland.
MeSH Terms
- Animals
- Bone Cysts, Aneurysmal / diagnostic imaging
- Bone Cysts, Aneurysmal / pathology
- Bone Cysts, Aneurysmal / surgery
- Bone Cysts, Aneurysmal / veterinary
- Bone Transplantation
- Bone and Bones / physiopathology
- Collagen
- Durapatite
- Female
- Horse Diseases / diagnostic imaging
- Horse Diseases / pathology
- Horse Diseases / surgery
- Horses
- Mandibular Diseases / diagnostic imaging
- Mandibular Diseases / pathology
- Mandibular Diseases / surgery
- Mandibular Diseases / veterinary
- Tissue Scaffolds
- Tomography, X-Ray Computed
Citations
This article has been cited 8 times.- Kolliopoulos V, Dewey MJ, Polanek M, Xu H, Harley BAC. Amnion and chorion matrix maintain hMSC osteogenic response and enhance immunomodulatory and angiogenic potential in a mineralized collagen scaffold.. Front Bioeng Biotechnol 2022;10:1034701.
- Power RN, Cavanagh BL, Dixon JE, Curtin CM, O'Brien FJ. Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications.. Int J Mol Sci 2022 Jan 27;23(3).
- Brady RT, O'Brien FJ, Hoey DA. The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line.. Bioengineering (Basel) 2022 Jan 13;9(1).
- Grzeskowiak RM, Alghazali KM, Hecht S, Donnell RL, Doherty TJ, Smith CK, Anderson DE, Biris AS, Adair HS. Influence of a novel scaffold composed of polyurethane, hydroxyapatite, and decellularized bone particles on the healing of fourth metacarpal defects in mares.. Vet Surg 2021 Jul;50(5):1117-1127.
- Dewey MJ, Nosatov AV, Subedi K, Shah R, Jakus A, Harley BAC. Inclusion of a 3D-printed Hyperelastic Bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold.. Acta Biomater 2021 Feb;121:224-236.
- Tiffany AS, Gray DL, Woods TJ, Subedi K, Harley BAC. The inclusion of zinc into mineralized collagen scaffolds for craniofacial bone repair applications.. Acta Biomater 2019 Jul 15;93:86-96.
- Dewey MJ, Johnson EM, Weisgerber DW, Wheeler MB, Harley BAC. Shape-fitting collagen-PLA composite promotes osteogenic differentiation of porcine adipose stem cells.. J Mech Behav Biomed Mater 2019 Jul;95:21-33.
- Lei P, Sun R, Wang L, Zhou J, Wan L, Zhou T, Hu Y. A New Method for Xenogeneic Bone Graft Deproteinization: Comparative Study of Radius Defects in a Rabbit Model.. PLoS One 2015;10(12):e0146005.
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