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Journal of animal science and technology2022; 64(5); 997-1007; doi: 10.5187/jast.2022.e52

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses.

Abstract: Delayed healing associated with distal limb wounds is highly challenging in equine clinical practice. This study aimed to evaluate healing rates between chronic non-granulating wounds of horse distal limbs that were treated with maltodextrin/ascorbic acid gel alone or in combination with povidone-iodine 1% solution and those treated with povidone-iodine 1% only throughout the study period (35 days) in clinical settings. The study was conducted on 18 adult horses (3-15 years old). Based on the treatment regimen utilized, the horses were divided into three groups (n = 6), with each group having a similar mean wound area. The percentages of wound contraction, epithelialization, and overall wound healing were determined weekly for each wound. By the end of the study, the total wound healing percentage was significantly increased between the study groups (p < 0.05). The use of maltodextrin/ascorbic acid gel resulted in considerable wound contraction, rapid epithelialization, and complication-free wound healing. Based on the findings of this study, maltodextrin/ascorbic acid gel, independently or in combination with a 1% povidone-iodine solution, might be applied as a safe and effective wound healing promoting agent in horses with chronic non-granulating wounds.
© Copyright 2022 Korean Society of Animal Science and Technology.
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Publication Date: 2022-09-30 PubMed ID: 36287738PubMed Central: PMC9574608DOI: 10.5187/jast.2022.e52Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on investigating the effectiveness of maltodextrin/ascorbic acid gel in enhancing the healing of distal limb chronic wounds in horses. The study compared wounds treated with this gel either alone or with a povidone-iodine 1% solution against wounds treated only with the povidone-iodine solution.

Study Design and Participants

  • The research was conducted on 18 adult horses aged between 3 and 15 years, who had chronic non-granulating wounds on their distal limbs.
  • The horses were divided into three groups (each made up of 6 horses) based on different treatment regimens. The initial size of wounds in all the groups was roughly the same.

Treatment Regimens

  • The first group of horses was treated with the maltodextrin/ascorbic acid gel only.
  • The second one was treated with a combination of the maltodextrin/ascorbic acid gel and a povidone-iodine 1% solution.
  • The third group was treated with the povidone-iodine 1% solution only, serving as a control group.

Evaluation Methodology

  • The treatment phase lasted for 35 days.
  • Each week, researchers evaluated the percentage contraction, epithelialization (the process by which skin cells grow over a wound), and the overall wound healing in each horse.

Results and Conclusion

  • At the end of the study, the researchers found that the use of maltodextrin/ascorbic acid gel treatments significantly increased the total wound healing percentage.
  • The researchers concluded that treatment with this gel, either by itself or alongside the povidone-iodine solution, resulted in a more significant wound contraction, quicker skin cell growth over the wound, and more complication-free healing than with povidone-iodine solution alone.
  • Therefore, the study suggests that maltodextrin/ascorbic acid gel usage can be an effective and safe method for treating chronic non-granulating wounds in horses.

Cite This Article

APA
Helal IE, Al-Abbadi HA, El-Daharawy MH, Ahmed MF. (2022). Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses. J Anim Sci Technol, 64(5), 997-1007. https://doi.org/10.5187/jast.2022.e52

Publication

Journal of animal science and technology
ISSN: 2055-0391
NlmUniqueID: 101661694
Country: Korea (South)
Language: English
Volume: 64
Issue: 5
Pages: 997-1007

Researcher Affiliations

Helal, Ibrahim E
  • Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
  • Equestrian Center Clinic, King Abdulaziz University, Jeddah 80212, Saudi Arabia.
Al-Abbadi, Hatim A
  • University Hospital, Faculty of Medicine, King Abdulaziz University, Jeddah 80212, Saudi Arabia.
El-Daharawy, Mohamed H
  • Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Ahmed, Mahmoud F
  • Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

Conflict of Interest Statement

No potential conflict of interest relevant to this article was reported.

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Citations

This article has been cited 3 times.
  1. Jha B, Majie A, Roy K, Gorain B. Functional and molecular insights in topical wound healing by ascorbic acid. Naunyn Schmiedebergs Arch Pharmacol 2025 Oct;398(10):13371-13396.
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  2. Ribeiro G, Carvalho L, Borges J, Prazeres J. The Best Protocol to Treat Equine Skin Wounds by Second Intention Healing: A Scoping Review of the Literature. Animals (Basel) 2024 May 18;14(10).
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  3. Afonso AC, Sousa M, Pinto AR, Cotovio M, Simões M, Saavedra MJ. Biofilm Production by Critical Antibiotic-Resistant Pathogens from an Equine Wound. Animals (Basel) 2023 Apr 13;13(8).
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