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Home / Equine Research Bank / Vet Ophthalmol / Eosinophilic keratitis in 46 eyes of 27 horses in the Mid-At...
Veterinary ophthalmology2013; 17(5); 311-320; doi: 10.1111/vop.12076

Eosinophilic keratitis in 46 eyes of 27 horses in the Mid-Atlantic United States (2008-2012).

Abstract: To review the signalment, clinical characteristics, treatment, and outcome of equine EK cases in the Mid-Atlantic United States; to evaluate the effects of topical or systemic corticosteroid treatment, oral cetirizine treatment and secondary corneal infection on disease duration; and to evaluate the association between corticosteroid and cetirizine treatment and likelihood of recurrence. Methods: Twenty-seven horses (47 eyes) diagnosed with EK from 2008 to 2012. Methods: Retrospective medical record review followed by phone interview to obtain recurrence data. Results: Average age of affected horses was 8.2 years, SD 5.8 years. Eleven of 27 horses (41%) were diagnosed with EK in July. Twelve horses (44%) had been affected in previous years. Time to resolution averaged 3.7 months, SD 2.3 months. Ten horses (18 eyes) were treated with systemic dexamethasone, with a significantly shorter time to resolution, P = 0.03, averaging 2.23 months, SD 1.13 months, relative to horses not so treated, averaging 4.20 months, SD 1.47 months. Secondary infection led to a significant increase in time to resolution, P = 0.03, average 4.1 months, SD 1.7 months, relative to horses without secondary infection, average 3.0 months, SD 1.5 months. All eyes were visual at resolution. Horses treated with cetirizine were less likely to have recurrence during the follow-up period (1/13, or 8%) relative to horses not so treated (8/14, or 57%). Conclusions: Eosinophilic keratitis has a seasonal occurrence in summer in the Mid-Atlantic United States. Systemic but not topical corticosteroid treatment may decrease therapy duration. Treatment with cetirizine may be associated with a decreased risk of recurrence.
© 2013 American College of Veterinary Ophthalmologists.
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Publication Date: 2013-06-14 PubMed ID: 23763548DOI: 10.1111/vop.12076Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study on eosinophilic keratitis (EK) in horses, specifically in the mid-Atlantic region of the United States, evaluating its characteristics, treatment methods, outcomes, and recurrence likelihood.

Study Overview

  • The study revolves around reviewing and investigating cases of eosinophilic keratitis (EK), a disease affecting the eyes in horses, occurring in the Mid-Atlantic region of the United States over a five-year period between 2008 and 2012.
  • A total of 46 eyes of 27 horses diagnosed with EK were studied retrospectively by reviewing medical records and performing phone interviews to gather evidence of recurrence.

Main Findings

  • The research discovered an average age of 8.2 years for affected horses, with 41% of horses diagnosed in July, indicating a potential seasonal occurrence in the summer.
  • It found that 44% of the horses had been affected in previous years, suggesting susceptibility to recurrence.
  • The disease’s resolution time averaged 3.7 months, but treatments could alter this duration. Specifically, systemic administration of a corticosteroid named dexamethasone led to quicker resolution.
  • Secondary infections extended the duration before the disease’s resolution.
  • At the end of the disease, all affected eyes regained their sight.
  • The study provided evidence that a medication named cetirizine, when used in treatment, could lower the likelihood of the disease recurring.

Conclusions

  • The study concludes that EK occurs seasonally in summer in the Mid-Atlantic United States.
  • Treatment with systemic corticosteroids, specifically dexamethasone, can help reduce the duration of therapy, whereas secondary infection can increase it.
  • The use of cetirizine in treatment may be associated with a decrease in the risk of EK recurrence.

Cite This Article

APA
Lassaline-Utter M, Miller C, Wotman KL. (2013). Eosinophilic keratitis in 46 eyes of 27 horses in the Mid-Atlantic United States (2008-2012). Vet Ophthalmol, 17(5), 311-320. https://doi.org/10.1111/vop.12076

Publication

Veterinary ophthalmology
ISSN: 1463-5224
NlmUniqueID: 100887377
Country: England
Language: English
Volume: 17
Issue: 5
Pages: 311-320

Researcher Affiliations

Lassaline-Utter, Mary
  • New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA, 19348, USA.
Miller, Chelsey
    Wotman, Kathryn L

      MeSH Terms

      • Administration, Oral
      • Animals
      • Anti-Allergic Agents / administration & dosage
      • Anti-Inflammatory Agents / administration & dosage
      • Cetirizine / administration & dosage
      • Dexamethasone / administration & dosage
      • Diagnostic Techniques, Ophthalmological / veterinary
      • Female
      • Horse Diseases / diagnosis
      • Horse Diseases / drug therapy
      • Horses
      • Keratitis / drug therapy
      • Keratitis / veterinary
      • Male
      • Mid-Atlantic Region
      • Ophthalmic Solutions
      • Recurrence
      • Retrospective Studies

      Citations

      This article has been cited 7 times.
      1. Romaneck AK, Sebbag L. Case Report: Clinical Remission in a Cat With Severe Bilateral Eosinophilic Keratitis Receiving Combined Immunosuppressive Therapy (Triamcinolone Acetonide and Tacrolimus). Front Vet Sci 2021;8:580396.
        doi: 10.3389/fvets.2021.580396pubmed: 33996955google scholar: lookup
      2. Flores MM, Del Piero F, Habecker PL, Langohr IM. A retrospective histologic study of 140 cases of clinically significant equine ocular disorders. J Vet Diagn Invest 2020 May;32(3):382-388.
        doi: 10.1177/1040638720912698pubmed: 32207378google scholar: lookup
      3. Knickelbein KE, Luethy D, Thomasy SM, Reilly C, Strom AR, Lassaline ME. Equine eosinophilic keratoconjunctivitis in California: retrospective study of 47 eyes from 29 cases (1993-2017). Vet Ophthalmol 2019 Jul;22(4):510-519.
        doi: 10.1111/vop.12621pubmed: 30706617google scholar: lookup
      4. Villatoro AJ, Claros S, Fernández V, Alcoholado C, Fariñas F, Moreno A, Becerra J, Andrades JA. Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment. BMC Vet Res 2018 Mar 27;14(1):116.
        doi: 10.1186/s12917-018-1413-4pubmed: 29587744google scholar: lookup
      5. Edwards S, Clode AB, Gilger BC. Equine eosinophilic keratitis in horses: 28 cases (2003-2013). Clin Case Rep 2015 Dec;3(12):1000-6.
        doi: 10.1002/ccr3.350pubmed: 26734136google scholar: lookup
      6. Sharkey LC, Seelig DM, Overmann J. All lesions great and small, part 2. Diagnostic cytology in veterinary medicine. Diagn Cytopathol 2014 Jun;42(6):544-52.
        doi: 10.1002/dc.23090pubmed: 24554415google scholar: lookup
      7. Sharun K, Banu SA, Alifsha B, Abualigah L, Pawde AM, Dhama K, Pal A. Mesenchymal stem cell therapy in veterinary ophthalmology: clinical evidence and prospects. Vet Res Commun 2024 Dec;48(6):3517-3531.
        doi: 10.1007/s11259-024-10522-wpubmed: 39212813google scholar: lookup
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