Epiglottic augmentation in the horse.
Abstract: Epiglottic augmentation with injectable bovine collagen or an autogenous or allogenous auricular cartilage graft was performed in 12 horses with endoscopically and radiographically normal epiglottises. The grafting procedures were easy to perform and did not cause apparent discomfort. Cartilage graft extrusion or resorption may have occurred, but was not seen by endoscopy and lateral laryngeal radiography. Only collagen implants remained evident endoscopically, as smooth round submucosal bulges ventral to the epiglottic cartilage. Two horses with collagen implants, and all horses with cartilage autografts and allografts, were euthanatized at week 16. One horse with a collagen implant was euthanatized at week 4 and one at week 6. The epiglottis appeared thickened in three horses with collagen implants, two horses with autogenous grafts, and three horses with allogenous grafts. Pharyngeal lymphoid tissue was hyperplastic in two horses with autografts and three horses with allografts, but not in horses with collagen implants. Collagen grafts persisted as one or two smooth bulges 8 mm in diameter. Collagen incited a brisk foreign body reaction that was surrounded by a fibrous connective tissue capsule. Epiglottises of the horses with collagen implants were significantly thicker 20 mm from the tip than those of normal horses and horses with allografts. Cartilage graft incorporation was not evident grossly and was seen on microscopic examination in only one autograft. Thickening was caused by submucosal fibrosis.
Publication Date: 1990-05-01 PubMed ID: 2349773DOI: 10.1111/j.1532-950x.1990.tb01164.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research article focuses on the study of epiglottic augmentation in horses using injectable bovine collagen or autogenous or allogenous auricular cartilage graft. The effectiveness and outcomes of these procedures were assessed in twelve horses.
Research Method
- Twelve horses with normal epiglottises, ascertained through endoscopic and radiographic examinations, were subjected to epiglottic augmentation procedures.
- Bovine collagen injections or cartilage grafts obtained from the same horse (autogenous) or a different horse (allogenous) were used.
Procedure Outcomes
- The procedures were reported to be quite straightforward and didn’t cause any visible discomfort to the horses.
- There could have been possible extrusion or resorption of the cartilage graft, but these weren’t observed through endoscopy and lateral laryngeal radiography.
- Only the collagen implants were particularly noticeable as smooth, round bulges beneath the mucous membrane, located ventrally to the epiglottic cartilage.
Euthanasia and Post-Mortem Observations
- A total of two horses with collagen implants and all horses with cartilage grafts (autografts and allografts) were euthanised on the 16th week for further examination.
- Increased thickness of the epiglottis was observed in three horses with collagen implants, two with autografts, and three with allografts.
- In some cases, pharyngeal lymphoid tissue showed hyperplasia (increased cell production) in the horses with autografts and allografts but not in those with collagen implants.
Analysis of Collagen Implants
- Collagen grafts remained as one or two smooth bulges around 8 mm in diameter.
- Critically, they incited a strong foreign body reaction, leading to encasement in a fibrous connective tissue capsule.
- Epiglottises of horses with collagen implants were significantly thicker at a distance of 20 mm from the tip compared to normal horses and horses with allografts, suggesting an impact of the collagen graft.
Outcomes of Cartilage Grafts
- Incorporation of cartilage grafts into the host tissue wasn’t explicitly evident and was detected only upon microscopic examination in a single autograft case.
- The thickening observed was attributed to submucosal fibrosis.
Cite This Article
APA
Tulleners E, Mann P, Raker CW.
(1990).
Epiglottic augmentation in the horse.
Vet Surg, 19(3), 181-190.
https://doi.org/10.1111/j.1532-950x.1990.tb01164.x Publication
Researcher Affiliations
- Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square.
MeSH Terms
- Animals
- Cartilage / transplantation
- Collagen
- Ear
- Epiglottis / anatomy & histology
- Epiglottis / surgery
- Female
- Horses / surgery
- Laryngoscopy / veterinary
- Male
- Postoperative Care / veterinary
- Prostheses and Implants / veterinary
- Transplantation, Autologous / veterinary
- Transplantation, Homologous / veterinary
Citations
This article has been cited 2 times.- Brown BN, Siebenlist NJ, Cheetham J, Ducharme NG, Rawlinson JJ, Bonassar LJ. Computed tomography-guided tissue engineering of upper airway cartilage. Tissue Eng Part C Methods 2014 Jun;20(6):506-13.
- Grevemeyer B, Bogdanovic L, Canton S, St Jean G, Cercone M, Ducharme NG, Brown BN. Regenerative medicine approach to reconstruction of the equine upper airway. Tissue Eng Part A 2014 Apr;20(7-8):1213-21.
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