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Home / Equine Research Bank / Am J Vet Res / Equine cerebrospinal fluid: reference values of normal horse...
American journal of veterinary research1977; 38(8); 1271-1274;

Equine cerebrospinal fluid: reference values of normal horses.

Abstract: Cerebrospinal fluid (CSF) samples were collected from the atlanto-occipital (AO) and lumbosacral (LS) subarachnoid spaces of 24 horses and 21 ponies that had no clinical evidence of neurologic disease. Depth of needle insertion, pressures, refractive index, rapid reagent strip test (protein, glucose, blood, pH) results, cell counts, content of protein, glucose, sodium, potassium, chloride, calcium, phosphorus, urea nitrogen, and cholesterol, and activities of creatine phosphokinase, aspartate transaminase, lactic dehydrogenase, and alkaline phosphatase were determined. The resulting clinical reference values obtained were discussed in light of the published normal values for CSF from horses, other animals, and man. White cell counts in CSF were found to be from 0 to 6/microliters. Values for protein content were distributed between wider limits than previously reported values. The LS-AO difference is proposed as a criterion for clinical evaluation of CSF protein content. Ponies were found to have more protein in their CSF than did the horses, and CSF from the LS site contained more glucose than that from the AO site. The CSF electrolyte composition was similar to that of previous reports. Enzyme activities in equine CSF are reported for the 1st time.
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Publication Date: 1977-08-01 PubMed ID: 911095
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research presents an analysis of the cerebrospinal fluid (CSF) from healthy horses and ponies with the aim to establish reference values for various elements present in the fluid.

Objective of the Research

  • The main purpose of this study was to collect and analyze cerebrospinal fluid (CSF) samples from 24 horses and 21 ponies that exhibited no clinical signs of neurological diseases. The objective was to establish reference points for several CSF components, to assist veterinary practitioners and researchers in recognising abnormal conditions.

Methodology

  • CSF samples were collected from two different regions – the atlanto-occipital (AO) and the lumbosacral (LS) subarachnoid spaces – of the subjects.
  • The depth of needle insertion, pressures, refractive index, and results of the rapid reagent strip test were noted. The strip test evaluated the presence and levels of protein, glucose, blood, and pH in the collected samples.
  • Further, cell counts, as well as the content of numerous substances including protein, glucose, sodium, potassium, chloride, calcium, phosphorus, urea nitrogen, and cholesterol were determined. In addition, the research also measured the activities of certain enzymes such as creatine phosphokinase, aspartate transaminase, lactic dehydrogenase, and alkaline phosphatase in the CSF – reported for the first time in horses.

Findings

  • The white cell count in the CSF was discovered to be from 0 to 6 per micro-liter.
  • The range of protein content in the CSF was found to be wider than previously reported. It was suggested to use the difference in protein content between the LS and AO sites as a criterion for clinical evaluation of CSF protein.
  • Ponies showed a higher protein content in their CSF compared to the horses.
  • CSF from the LS site contained more glucose compared to that from the AO site.
  • The chemical composition (electrolytes) of the CSF samples was found to be similar to previously reported studies.

Implications

  • The findings offer important insights and reference values for crucial components in the CSF of healthy horses and ponies. They provide a baseline for comparison with figures from animals suspected to have neurological disorders, potentially helping in the diagnosis and treatment of said disorders.

Cite This Article

APA
Mayhew IG, Whitlock RH, Tasker JB. (1977). Equine cerebrospinal fluid: reference values of normal horses. Am J Vet Res, 38(8), 1271-1274.

Publication

American journal of veterinary research
ISSN: 0002-9645
NlmUniqueID: 0375011
Country: United States
Language: English
Volume: 38
Issue: 8
Pages: 1271-1274

Researcher Affiliations

Mayhew, I G
    Whitlock, R H
      Tasker, J B

        MeSH Terms

        • Animals
        • Female
        • Glucose / cerebrospinal fluid
        • Horses / cerebrospinal fluid
        • Male
        • Reference Values
        • Specimen Handling / veterinary

        Citations

        This article has been cited 17 times.
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