Equine-derived bone mineral matrix for maxillary sinus floor augmentation: a clinical, radiographic, histologic, and histomorphometric case series.
Abstract: The objective of this proof-of-principle multicenter case series was to examine the bone regenerative potential of a newly introduced equine-derived bone mineral matrix (Equimatrix) to provide human sinus augmentation for the purpose of implant placement in the posterior maxilla. There were 10 patients requiring 12 maxillary sinus augmentations enrolled in this study. Histologic results at 6 months demonstrated abundant amounts of vital new bone in intimate contact with residual graft particles. Active bridging between residual graft particles with newly regenerated bone was routinely observed in intact core specimens. A mean value of 23.4% vital bone formation was observed at 6 months. This compared favorably with previous results using xenografts to produce bone in the maxillary sinus for the purpose of dental implant placement. Both the qualitative and quantitative results of this case series suggest comparable bone regenerative results at 6 months to bovine-derived xenografts.
Publication Date: 2013-07-04 PubMed ID: 23820708DOI: 10.11607/prd.1728Google Scholar: Lookup
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- Clinical Trial
- Comparative Study
- Journal Article
- Multicenter Study
- Research Support
- Non-U.S. Gov't
Summary
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This research studied the potential of a new equine-derived bone mineral matrix (Equimatrix) in regenerating bone for human sinus augmentation, with the aim of placing dental implants in the upper jaw. The results showed promising signs of vital new bone formation in contact with graft particles, comparable to previous methods using xenografts.
Objective and Methodology
- The main objective of this multicenter case series was to assess the bone regenerative capabilities of Equimatrix, a new equine-derived bone mineral matrix. This was done with the intention of using it for sinus augmentation in preparation for dental implant placement in the posterior maxilla (the upper jaw).
- The study enrolled 10 patients and performed a total of 12 maxillary sinus augmentations. The histologic results were taken at a period of 6 months.
Results and Findings
- After a period of 6 months, histologic results revealed substantial amounts of new, vital bone in close contact with the residual graft particles.
- Active bridging between the leftover graft particles and the newly regenerated bone was observed routinely in intact core samples.
- The mean value of vital bone formation observed at the end of the 6-month period was 23.4%. This is a significant proportion considering the relatively short period of observation.
- These results were found to be similar to those obtained through the use of xenografts – a process where tissue is transferred from one species to another – to grow bone in the maxillary sinus for dental implant purposes.
Conclusion
- According to both qualitative and quantitative results of this case series, the bone regenerative outcome of Equimatrix is comparable to that of bovine-derived xenografts after a 6-month period.
- These favorable results point to a promising new alternative for bone regeneration in dental implant procedures. The use of an equine-derived bone mineral matrix may offer equal, if not superior, efficacy as that of xenografts.
Cite This Article
APA
Nevins M, Heinemann F, Janke UW, Lombardi T, Nisand D, Rocchietta I, Santoro G, Schupbach P, Kim DM.
(2013).
Equine-derived bone mineral matrix for maxillary sinus floor augmentation: a clinical, radiographic, histologic, and histomorphometric case series.
Int J Periodontics Restorative Dent, 33(4), 483-489.
https://doi.org/10.11607/prd.1728 Publication
Researcher Affiliations
- Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Ave., Boston, MA 02115, USA. nevinsperimp@aol.com
MeSH Terms
- Adult
- Aged
- Animals
- Biopsy / methods
- Bone Density / physiology
- Bone Marrow / pathology
- Bone Matrix / diagnostic imaging
- Bone Matrix / pathology
- Bone Matrix / transplantation
- Bone Regeneration / physiology
- Bone Substitutes / therapeutic use
- Cattle
- Dental Implants
- Female
- Follow-Up Studies
- Heterografts / diagnostic imaging
- Heterografts / pathology
- Heterografts / transplantation
- Horses
- Humans
- Image Processing, Computer-Assisted / methods
- Male
- Maxilla / pathology
- Membranes, Artificial
- Middle Aged
- Osteocytes / pathology
- Osteogenesis / physiology
- Osteotomy / methods
- Radiography
- Sinus Floor Augmentation / methods
- Surgical Flaps / surgery
- Young Adult
Citations
This article has been cited 7 times.- Susin C, Lee J, Fiorini T, Koo KT, Schüpbach P, Finger Stadler A, Wikesjö UM. Screening of Hydroxyapatite Biomaterials for Alveolar Augmentation Using a Rat Calvaria Critical-Size Defect Model: Bone Formation/Maturation and Biomaterials Resolution.. Biomolecules 2022 Nov 12;12(11).
- Grasso G, Mummolo S, Bernardi S, Pietropaoli D, D'Ambrosio G, Iezzi G, Piattelli A, Bianchi S, Marchetti E. Histological and Histomorphometric Evaluation of New Bone Formation after Maxillary Sinus Augmentation with Two Different Osteoconductive Materials: A Randomized, Parallel, Double-Blind Clinical Trial.. Materials (Basel) 2020 Dec 3;13(23).
- D'Amato RD, Memeo A, Fusini F, Panuccio E, Peretti G. Treatment of simple bone cyst with bone marrow concentrate and equine-derived demineralized bone matrix injection versus methylprednisolone acetate injections: A retrospective comparative study.. Acta Orthop Traumatol Turc 2020 Jan;54(1):49-58.
- La Monaca G, Iezzi G, Cristalli MP, Pranno N, Sfasciotti GL, Vozza I. Comparative Histological and Histomorphometric Results of Six Biomaterials Used in Two-Stage Maxillary Sinus Augmentation Model after 6-Month Healing.. Biomed Res Int 2018;2018:9430989.
- Stacchi C, Lombardi T, Oreglia F, Alberghini Maltoni A, Traini T. Histologic and Histomorphometric Comparison between Sintered Nanohydroxyapatite and Anorganic Bovine Xenograft in Maxillary Sinus Grafting: A Split-Mouth Randomized Controlled Clinical Trial.. Biomed Res Int 2017;2017:9489825.
- Annibali S, Iezzi G, Sfasciotti GL, Cristalli MP, Vozza I, Mangano C, La Monaca G, Polimeni A. Histological and Histomorphometric Human Results of HA-Beta-TCP 30/70 Compared to Three Different Biomaterials in Maxillary Sinus Augmentation at 6 Months: A Preliminary Report.. Biomed Res Int 2015;2015:156850.
- Jamjoom A, Cohen RE. Grafts for Ridge Preservation.. J Funct Biomater 2015 Aug 7;6(3):833-48.
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