Equine herpesviruses 2 and 5: comparisons with other members of the subfamily gammaherpesvirinae.
Abstract: This chapter describes the molecular and biological properties of equine herpesviruses (EHV)2 and EHV5. It highlights advances in the study of EHV2 and EHV5. The reclassification of EHV2 and EHV5 as gammaherpesviruses rather than betaherpesviruses has profound implications for future approaches to the study of the two equine herpesviruses. The chapter places emphasis on a comparison between the properties of EHV2 and EHV5 and those of other gammaherpesviruses, especially Epstein-Barr virus (EBV), which is the causative agent of infectious mononucleosis/glandular fever in humans. Studies of the molecular biology of EHVB and EHV5 have led to an understanding of the genome and, to a lesser extent, protein compositions of the viruses. Significant differences exist between EHVB and EHV5 at both levels. Determination of DNA sequences within the EHVB and EHV5 genomes has not only confirmed the separate identities of these two equine viruses, but has shown that they are not betaherpesviruses as previously thought. Instead, EHVB and EHV5 are more properly classified as members of the Gammaherpesvirinae.
Publication Date: 1994-01-01 PubMed ID: 7817877DOI: 10.1016/s0065-3527(08)60333-4Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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This research article delves into the properties of equine herpesviruses (EHV) 2 and 5, comparing them with other member viruses of the gammaherpesvirinae subfamily, and discusses their reclassification from betaherpesviruses to gammaherpesviruses.
Understanding EHV2 and EHV5
- This section of the research article deals with the molecular and biological properties of EHV2 and EHV5. The study aims to bring forward the advances in understanding these viruses.
- The shift from betaherpesvirinae to gammaherpesvirinae for EHV2 and EHV5, based on recent studies, is an important point of discussion. The authors propose that this switch carries significant implications for future research into these equine viruses.
Comparisons with other gammaherpesviruses
- The article provides a comparative analysis of EHV2 and EHV5 with other gammaherpesviruses—specifically, the Epstein-Barr virus (EBV)—which is responsible for causing infectious mononucleosis or glandular fever in humans.
- The study also discusses how the investigation into the molecular biology of EBV has led to a better understanding of the genomic and protein compositions of EHV2 and EHV5.
Differences and Reclassification
- Considerable differences exist between EBV and EHV2 and EHV5 in terms of their genomic sequences and protein makeup.
- The determination of DNA sequences and their analysis within EBV and the two equine viruses confirmed that they have separate identities. This revelation prompted the reconsideration of their classification, ultimately leading to the conclusion that EHV2 and EHV5 are not betaherpesviruses, as initially thought.
- Based on the specific characteristics and the genomic sequence data gathered, the article concludes that EHV2 and EHV5 are more accurately classified under the Gammaherpesvirinae subfamily.
Cite This Article
APA
Agius CT, Studdert MJ.
(1994).
Equine herpesviruses 2 and 5: comparisons with other members of the subfamily gammaherpesvirinae.
Adv Virus Res, 44, 357-379.
https://doi.org/10.1016/s0065-3527(08)60333-4 Publication
Researcher Affiliations
- School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
MeSH Terms
- Animals
- Genome, Viral
- Herpesviridae / classification
- Herpesviridae / genetics
- Herpesviridae / growth & development
- Horses / virology
Citations
This article has been cited 7 times.- Wang T, Xi C, Yu Y, Liu W, Akhtar MF, Li Y, Wang C, Li L. Characteristics and epidemiological investigation of equid herpesvirus 8 in donkeys in Shandong, China.. Arch Virol 2023 Mar 4;168(3):99.
- Craig MI, Barrandeguy ME, Fernández FM. Equine herpesvirus 2 (EHV-2) infection in thoroughbred horses in Argentina.. BMC Vet Res 2005 Nov 9;1:9.
- Camarda G, Spinetti G, Bernardini G, Mair C, Davis-Poynter N, Capogrossi MC, Napolitano M. The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor.. J Virol 1999 Dec;73(12):9843-8.
- Wang X, Hutt-Fletcher LM. Epstein-Barr virus lacking glycoprotein gp42 can bind to B cells but is not able to infect.. J Virol 1998 Jan;72(1):158-63.
- Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.. Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1172-6.
- Drummer HE, Reubel GH, Studdert MJ. Equine gammaherpesvirus 2 (EHV2) is latent in B lymphocytes.. Arch Virol 1996;141(3-4):495-504.
- Secchiero P, Nicholas J, Deng H, Xiaopeng T, van Loon N, Ruvolo VR, Berneman ZN, Reitz MS Jr, Dewhurst S. Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity.. J Virol 1995 Dec;69(12):8041-5.
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