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Veterinary microbiology2013; 167(1-2); 135-144; doi: 10.1016/j.vetmic.2013.07.010

Equine rotaviruses–current understanding and continuing challenges.

Abstract: Equine rotaviruses were first detected in foals over 30 years ago and remain a major cause of infectious diarrhoea in foals. During this time, there has been substantial progress in the development of sensitive methods to detect rotaviruses in foals, enabling surveillance of the genotypes present in various horse populations. However, there has been limited epidemiological investigation into the significance of these circulating genotypes, their correlation with disease and the use of vaccination in these animal populations. Our knowledge of the pathogenesis of rotavirus infection in foals is based on a limited number of studies on a small number of foals and, therefore, most of our understanding in this area has been extrapolated from studies in other species. Questions such as the concentrations of rotavirus particles shed in the faeces of infected foals, both with and without diarrhoea, and factors determining the presence or absence of clinical disease remain to be investigated, as does the relative and absolute efficacy of currently available vaccines. The answer to these questions may help direct research into the development of more effective control measures.
Copyright © 2013 Elsevier B.V. All rights reserved.
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Publication Date: 2013-07-22 PubMed ID: 23932076PubMed Central: PMC7117381DOI: 10.1016/j.vetmic.2013.07.010Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the current understanding and ongoing challenges in dealing with equine rotaviruses which are a leading cause of infectious diarrhea in young horses. It highlights the advancements made in detecting these viruses in horse populations, the need for further epidemiological research, and the gaps in our current knowledge regarding the pathogenesis of rotavirus infections in foals.

Improved Detection Methods and Surveillance

  • The article points out that development in the methods to identify rotaviruses in foals has seen significant advancement in the last 30 years. This has facilitated surveillance of the virus genotypes present in different horse populations, creating a more comprehensive understanding of the viral diversity.

Limited Epidemiological Investigation

  • The author mentions that despite progress in detection, there has been a lack of extensive epidemiological research into the relevance of circulating genotypes and their correlation with the disease. It’s crucial to understand whether specific genotypes are linked to higher disease severity to inform treatment and prevention strategies.

Understanding of Pathogenesis

  • Our limited understanding of how rotavirus infection develops in foals also poses challenges. Much of our knowledge is derived from extrapolation from studies of other species, as there have not been many studies conducted directly on foals. This could lead to inaccuracies in our understanding given the potential species-specific differences.
  • The article emphasizes that there are outstanding questions such as the concentrations of rotavirus particles found in the feces of infected foals and the factors determining the presence or absence of clinical disease, which need investigating.

Vaccination and Control Measures

  • Further, the efficacy of currently available vaccines is also yet to be fully understood. Determining the vaccines’ relative and absolute effectiveness will be key to developing more effective preventative measures.
  • Researching these areas will help guide future efforts towards developing more effective control measures, addressing the ongoing challenge of managing equine rotaviruses.

Cite This Article

APA
Bailey KE, Gilkerson JR, Browning GF. (2013). Equine rotaviruses–current understanding and continuing challenges. Vet Microbiol, 167(1-2), 135-144. https://doi.org/10.1016/j.vetmic.2013.07.010

Publication

Veterinary microbiology
ISSN: 1873-2542
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 167
Issue: 1-2
Pages: 135-144

Researcher Affiliations

Bailey, Kirsten E
  • Centre for Equine Infectious Diseases, Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: baileyk@unimelb.edu.au.
Gilkerson, James R
    Browning, Glenn F

      MeSH Terms

      • Animals
      • Horse Diseases / diagnosis
      • Horse Diseases / epidemiology
      • Horse Diseases / pathology
      • Horse Diseases / virology
      • Horses
      • Rotavirus / classification
      • Rotavirus / immunology
      • Rotavirus / physiology
      • Rotavirus Infections / diagnosis
      • Rotavirus Infections / epidemiology
      • Rotavirus Infections / pathology
      • Rotavirus Infections / veterinary
      • Rotavirus Infections / virology

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