Equine sarcoid of the glans penis with bovine papillomavirus type 1 in a miniature horse (Falabella).
Abstract: A 23-year-old Falabella gelding kept in Tochigi, Japan, for more than 20 years presented with a recurrent mass of the glans penis that was first noticed about a year earlier. Partial phallectomy was performed with no adjunctive therapy for local regrowth of the mass. The horse was euthanized 3 months after surgery for urinary retention due to suspected regrowth. The resected mass affected the genital and urethral mucosa of the glans penis, and was diagnosed as equine sarcoid by histopathology and identification of bovine papillomavirus (BPV) DNA. Phylogenetic analysis of the BPV genome of the sarcoid showed high sequence homology to BPV type 1 (BPV-1) from Hokkaido, Japan, suggesting a geographical relationship for BPV-1 in Japan.
Publication Date: 2021-04-28 PubMed ID: 33907057PubMed Central: PMC8267208DOI: 10.1292/jvms.21-0170Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research involves a case study on a horse that had a recurring tumor, equine sarcoid, on its penis, which was found to have genetic similarities with a bovine papillomavirus type 1 (BPV-1) identified in another geographical part of Japan.
Case Details
- The subject of the study was a 23-year-old small-sized horse breed, referred to as Falabell geldinga, which was kept in Tochigi, Japan, for over 20 years.
- A recurrent tumor-like mass was identified on the horse’s penis, approximately a year before the study was conducted.
- Despite partial removal of the penis (partial phallectomy), the mass reappeared, causing urinary retention that necessitated the euthanization of the horse three months after surgery.
Findings
- The researchers investigated the resected tumor mass that was affecting both the genital and urethral mucosa of the horse’s penis.
- The tumor was diagnosed as equine sarcoid, a common type of skin tumor in horses, through histopathological analysis. Accompanying DNA tests identified the presence of bovine papillomavirus (BPV), a virus known to cause such tumors.
- Upon further phylogenetic scrutiny, it was found that the BPV genome from the tumor had a high sequence similarity to BPV type 1 (BPV-1), found in Hokkaido, Japan. This points towards a possible geographical linkage of this virus strain within Japan.
Implications
- The study expands our understanding of equine sarcoid, offering insights into its association with BPV looms.
- Notably, the study exposes a potential geographical relationship for BPV-1 in Japan, hinting at a regional viral spread.
This could prove crucial in developing strategies to control the spread of BPV and minimize equine sarcoid cases in the country.
Cite This Article
APA
Ogihara K, Ishihara A, Nagai M, Yamada K, Mizutani T, Harafuji M, Nishio H, Madarame H.
(2021).
Equine sarcoid of the glans penis with bovine papillomavirus type 1 in a miniature horse (Falabella).
J Vet Med Sci, 83(6), 1016-1021.
https://doi.org/10.1292/jvms.21-0170 Publication
Researcher Affiliations
- Laboratory of Pathology, School of Life and Environmental Science, Azabu University, Kanagawa 252-5201, Japan.
- Laboratory of Farm Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
- Laboratory of Infectious Diseases, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
- Laboratory of Clinical Diagnosis, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
- Research and Education Center for Prevention of Global Infectious Diseases of Animal, Tokyo University of Agriculture and Technology, Tokyo 183-0054, Japan.
- Nasu Animal Kingdom, Tochigi 329-3223, Japan.
- Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, Kanagawa 252-5201, Japan.
- Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, Kanagawa 252-5201, Japan.
MeSH Terms
- Animals
- Bovine papillomavirus 1 / genetics
- DNA, Viral
- Horse Diseases
- Horses
- Japan
- Male
- Papillomavirus Infections / veterinary
- Penis / surgery
- Phylogeny
- Skin Neoplasms / veterinary
Conflict of Interest Statement
The authors declare no conflicts of interest regarding the publicationof this manuscript.
References
This article includes 29 references
- Altamura G, Tommasino M, Borzacchiello G. Cutaneous vs. mucosal tropism: the papillomavirus paradigm comes to an “and”. Front. Microbiol. 11: 588663.
- Bogaert L, Martens A, Depoorter P, Gasthuys F. Equine sarcoids−part 1: clinical presentation and epidemiology. Vlaams Diergeneeskd. Tijdschr. 77: 2–9.
- Bogaert L, Heerden M V, Cock H E V, Martens A, Chiers K. Molecular and immunohistochemical distinction of equine sarcoid from schwannoma. Vet. Pathol. 48: 737–741.
- de Villiers E M. Cross-roads in the classification of papillomaviruses. Virology 445: 2–10.
- Epperson E D, Castleman W L. Bovine papillomavirus DNA and S100 profiles in sarcoids and other cutaneous spindle cell tumors in horses. Vet. Pathol. 54: 44–52.
- Felsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39: 783–791.
- Gardiner D W, Teifke J P, Podell B K, Kamstock D A. Fibropapilloma of the glans penis in a horse. J. Vet. Diagn. Invest. 20: 816–819.
- Hendrick M J. Mesenchymal tumors of the skin and soft tissues. pp. 142–175. In: Tumors in Domestic Animals, 5th ed. (Meuten, D. J. ed.), John Wiley & Sons, Ames.
- Jackson C. The incidence and pathology of tumors of domesticated animals in South Africa. Onderstepoort. J. Vet. Sci. Anim. Indust. 6: 378–385.
- Kish G F, Nazhvani S D, Namazi F, Jalali Y. Penile sarcoid in horse: clinicopathological characteristics with brief literature review. Comp. Clin. Pathol. 23: 459–462.
- Ko K, Arora P, Lee W, McCulloch C. Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am. J. Physiol. Cell Physiol. 279: C147–C157.
- Kumar S, Stecher G, Tamura K. MEGA7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol. Biol. Evol. 33: 1870–1874.
- Manos M M, Ting Y, Wright D K, Lewis A I, Broker T R, Wolinsky S M. The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. Cancer Cells 7: 209–214.
- Mauldin E A, Peters-Kennedy J. Papilloma and papillomavirus-induced lesions. pp. 706–712. In: Jubb, Kennedy and Palmer’s Pathology of Domestic Animals (Volume 1), 6th ed. (Maxie, M. G. ed.), Elsevier Science, St. Louis.
- Munday J, Pesavento P. Chapter 11 Papillomaviridae and Polyomaviridae. pp. 229–243. In: Fenner’s Veterinary Virology, 5th ed. (MacLachlan, N. J. and Dubovi, E. J. eds.), Academic Press, Cambridge.
- Ogłuszka M, Starzyński R R, Pierzchała M, Otrocka-Domagała I, Raś A. Equine sarcoids—causes, molecular changes, and clinicopathologic features: a review. Vet. Pathol. 58: 472–482.
- Oyamada T, Akachi S, Yoshikawa H, Yoshikawa T. Pathological studies on equine sarcoid in Japan. Pathological findings of 31 cases. Jpn. J. Equine Sci. 2: 31–39.
- Paschoud S, Bongiovanni M, Pache J C, Citi S. Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod. Pathol. 20: 947–954.
- Roccabianca P, Schulman F Y, Avallone G, Foster R A, Scruggs J L, Dittmer K, Kiupel M. Equine sarcoid. pp. 91–97. In: Surgical Pathology of Tumors of Domestic Animals, Volume 3, Tumors of Soft Tissue (Kiupel, M. ed.), Davis-Thompson Foundation, Grunee.
- Saadi A, Azizi S, Farshid A A, Yousefi A. Surgical management of penile sarcoid in a stallion. J. Equine Sci. 30: 99–104.
- Scott D W, Miller W H Jr. Sarcoid. pp. 479–488. In: Equine Dermatology, 2nd ed., Elsevier Science, St. Louis.
- Scott V H L, Hughes K. Diagnosis of equine penile and preputial masses: a clinical and pathological perspective. Equine Vet. Educ. 29: 10–14.
- Shimakura H, Dong J, Zhu W, Chambers J K, Uchida K, Kiriki K, Uematsu M, Goto Y, Yasuda M, Yamashita-Kawanishi N, Tsuzuki M, Le D T, Hatama S, Haga T. Full genome analysis of bovine papillomavirus type 1 derived from a calf with severe cutaneous multiple papillomatosis. J. Vet. Med. Sci. 80: 1691–1695.
- Suh Y, Yoon C H, Kim R K, Lim E J, Oh Y S, Hwang S G, An S, Yoon G, Gye M C, Yi J M, Kim M J, Lee S J. Claudin-1 induces epithelial-mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells. Oncogene 32: 4873–4882.
- Thway K, Fisher C, Debiec-Rychter M, Calonje E. Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum. Pathol. 40: 1586–1590.
- Van Den Top J G B, Ensink J M, Gröne A, Klein W R, Barneveld A, Van Weeren P R. Penile and preputial tumours in the horse: literature review and proposal of a standardised approach. Equine Vet. J. 42: 746–757.
- Vashisht K, Rock R W, Summers B A. Multiple masses in a horse’s tongue resulting from an atypical perineurial cell proliferative disorder. Vet. Pathol. 44: 398–402.
- Wobeser B K. Making the diagnosis. Vet. Pathol. 54: 9–10.
- Yamashita-Kawanishi N, Chambers J K, Uchida K, Tobari Y, Yoshimura H, Yamamoto M, Yumoto N, Aoki H, Sugiura K, Higuchi T, Saito S, Haga T. Genomic characterisation of bovine papillomavirus types 1 and 2 identified in equine sarcoids in Japan. Equine Vet. J. .
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
