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The Journal of veterinary medical science2021; 83(6); 1016-1021; doi: 10.1292/jvms.21-0170

Equine sarcoid of the glans penis with bovine papillomavirus type 1 in a miniature horse (Falabella).

Abstract: A 23-year-old Falabella gelding kept in Tochigi, Japan, for more than 20 years presented with a recurrent mass of the glans penis that was first noticed about a year earlier. Partial phallectomy was performed with no adjunctive therapy for local regrowth of the mass. The horse was euthanized 3 months after surgery for urinary retention due to suspected regrowth. The resected mass affected the genital and urethral mucosa of the glans penis, and was diagnosed as equine sarcoid by histopathology and identification of bovine papillomavirus (BPV) DNA. Phylogenetic analysis of the BPV genome of the sarcoid showed high sequence homology to BPV type 1 (BPV-1) from Hokkaido, Japan, suggesting a geographical relationship for BPV-1 in Japan.
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Publication Date: 2021-04-28 PubMed ID: 33907057PubMed Central: PMC8267208DOI: 10.1292/jvms.21-0170Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research involves a case study on a horse that had a recurring tumor, equine sarcoid, on its penis, which was found to have genetic similarities with a bovine papillomavirus type 1 (BPV-1) identified in another geographical part of Japan.

Case Details

  • The subject of the study was a 23-year-old small-sized horse breed, referred to as Falabell geldinga, which was kept in Tochigi, Japan, for over 20 years.
  • A recurrent tumor-like mass was identified on the horse’s penis, approximately a year before the study was conducted.
  • Despite partial removal of the penis (partial phallectomy), the mass reappeared, causing urinary retention that necessitated the euthanization of the horse three months after surgery.

Findings

  • The researchers investigated the resected tumor mass that was affecting both the genital and urethral mucosa of the horse’s penis.
  • The tumor was diagnosed as equine sarcoid, a common type of skin tumor in horses, through histopathological analysis. Accompanying DNA tests identified the presence of bovine papillomavirus (BPV), a virus known to cause such tumors.
  • Upon further phylogenetic scrutiny, it was found that the BPV genome from the tumor had a high sequence similarity to BPV type 1 (BPV-1), found in Hokkaido, Japan. This points towards a possible geographical linkage of this virus strain within Japan.

Implications

  • The study expands our understanding of equine sarcoid, offering insights into its association with BPV looms.
  • Notably, the study exposes a potential geographical relationship for BPV-1 in Japan, hinting at a regional viral spread.

    • This could prove crucial in developing strategies to control the spread of BPV and minimize equine sarcoid cases in the country.

Cite This Article

APA
Ogihara K, Ishihara A, Nagai M, Yamada K, Mizutani T, Harafuji M, Nishio H, Madarame H. (2021). Equine sarcoid of the glans penis with bovine papillomavirus type 1 in a miniature horse (Falabella). J Vet Med Sci, 83(6), 1016-1021. https://doi.org/10.1292/jvms.21-0170

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 83
Issue: 6
Pages: 1016-1021

Researcher Affiliations

Ogihara, Kikumi
  • Laboratory of Pathology, School of Life and Environmental Science, Azabu University, Kanagawa 252-5201, Japan.
Ishihara, Akikazu
  • Laboratory of Farm Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
Nagai, Makoto
  • Laboratory of Infectious Diseases, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
Yamada, Kazutaka
  • Laboratory of Clinical Diagnosis, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
Mizutani, Testuya
  • Research and Education Center for Prevention of Global Infectious Diseases of Animal, Tokyo University of Agriculture and Technology, Tokyo 183-0054, Japan.
Harafuji, Mei
  • Nasu Animal Kingdom, Tochigi 329-3223, Japan.
Nishio, Hisanari
  • Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, Kanagawa 252-5201, Japan.
Madarame, Hiroo
  • Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, Kanagawa 252-5201, Japan.

MeSH Terms

  • Animals
  • Bovine papillomavirus 1 / genetics
  • DNA, Viral
  • Horse Diseases
  • Horses
  • Japan
  • Male
  • Papillomavirus Infections / veterinary
  • Penis / surgery
  • Phylogeny
  • Skin Neoplasms / veterinary

Conflict of Interest Statement

The authors declare no conflicts of interest regarding the publicationof this manuscript.

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