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Home / Equine Research Bank / Vet Rec / Equine skeletal scintigraphy: Comparing normal bone-to-soft ...
The Veterinary record2022; 191(10); e2077; doi: 10.1002/vetr.2077

Equine skeletal scintigraphy: Comparing normal bone-to-soft tissue ratio 2 and 4 hours after injection with either hydroxymethylene diphosphonate or methylene diphosphonate.

Abstract: In equine skeletal scintigraphy, there is no information about the possible influence of different phosphonate compounds on image quality. This prospective randomised study determined bone uptake changes and image quality for hydroxymethylene diphosphonate (HDP) and methylene diphosphonate (MDP) in equine patients at different time points. Scintigraphic images of the radius and the tibia of 20 horses were acquired at 2 and 4 hours after injection of either technetium-labelled HDP or MDP. Three regions of interest were identified-in the bone diaphysis, adjacent soft tissue and background area-to determine the normal bone-to-soft tissue ratio (BSR). Qualitative analysis was performed using a modified scoring system. In terms of BSR and count rates, HDP showed a slightly better incorporation into bone compared to MDP, but significant differences were only detected for count rates at 4 hours after injection (p = 0.048). The radiopharmaceutical used did not influence qualitative image scoring, which was correlated with the BSR (ρ = 0.49; p ≤ 0.001). The choice of HDP or MDP for equine skeletal scintigraphy does not seem to substantially affect BSR and qualitative image scoring. Further studies with a larger sample size, including the evaluation of lesion detection ability for both bone-seeking agents, are needed.
© 2022 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.
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Publication Date: 2022-08-24 PubMed ID: 36000607DOI: 10.1002/vetr.2077Google Scholar: Lookup
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  • Randomized Controlled Trial
  • Veterinary
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigated two different compounds (hydroxymethylene diphosphonate and methylene diphosphonate) used in horse bone images and found that the compound used does not significantly affect image quality or bone to soft tissue ratios.

Objective of the Study

  • The main objective of this study was to examine the possible effects of different phosphonate compounds on the quality of equine skeletal scintigraphy. Equine skeletal scintigraphy involves taking images of horse bones using a specific radioactive compound.

Research Methodology

  • This was a prospective randomised study involving 20 horses, with images of their radius and tibia being taken 2 and 4 hours after an injection of either technetium-labelled HDP or MDP.
  • The images were analysed both quantitatively and qualitatively, using count rates and a modified scoring system respectively.

Main Findings

  • The results showed that HDP lead to slightly better incorporation into the bones compared to MDP. However, the differences were only pronounced in count rates 4 hours post-injection and were statistically significant (p = 0.048).
  • The compound used, either HDP or MDP, didn’t significantly influence the bone-to-soft-tissue ratio (BSR) or the qualitative image scoring.
  • The qualitative image scoring had a positive correlation with the BSR with statistical significance (ρ = 0.49; p ≤ 0.001).

Conclusion and Recommendation

  • The study concludes that the choice of HDP or MDP does not seem to substantially affect BSR and qualitative image scoring in equine skeletal scintigraphy.
  • However, the researchers recommend further studies with a larger sample size, including the ability to detect lesions using each of these bone-seeking agents.

Cite This Article

APA
Pelli AC, Winter K, Offhaus J, Brehm W, Gerlach K. (2022). Equine skeletal scintigraphy: Comparing normal bone-to-soft tissue ratio 2 and 4 hours after injection with either hydroxymethylene diphosphonate or methylene diphosphonate. Vet Rec, 191(10), e2077. https://doi.org/10.1002/vetr.2077

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 191
Issue: 10
Pages: e2077

Researcher Affiliations

Pelli, Anna C
  • Department for Horses, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
Winter, Karsten
  • Institute of Anatomy, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Offhaus, Julia
  • Tierärztliche Praxis für Pferde, Borstel-Hohenraden, Germany.
Brehm, Walter
  • Department for Horses, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
Gerlach, Kerstin
  • Department for Horses, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

MeSH Terms

  • Animals
  • Horses
  • Technetium Tc 99m Medronate
  • Prospective Studies
  • Diphosphonates / metabolism
  • Radionuclide Imaging
  • Radiopharmaceuticals / metabolism

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Citations

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