Equine ulcerative keratitis.
Abstract: Ulcerative keratitis is one of the most common vision-threatening diseases of the horse. Successful therapy, however, can be achieved in the majority of cases provided the diagnosis is made early and the treatment is specific for the disease. This article reviews the pathophysiology, clinical signs, and contemporary medical and surgical approaches to bacterial and fungal ulcerative keratitis in the horse.
Publication Date: 1992-12-01 PubMed ID: 1458328DOI: 10.1016/s0749-0739(17)30440-6Google Scholar: Lookup
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Summary
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The research article presents a comprehensive study on ulcerative keratitis, a vision-threatening equine disease. It explores the disease’s pathophysiology, ways to diagnose, and the latest medical and surgical treatment options for equine ulcerative keratitis.
Understanding Ulcerative Keratitis in Horses
- Ulcerative keratitis is a prevalent equine disease that poses significant risks to a horse’s vision. It is a condition wherein the cornea, the front surface of the eye, develops an ulcer or sores, leading to inflammation, pain, and potential loss of sight.
- The article underscores the fact that prompt diagnosis and appropriate treatment are paramount in managing this condition successfully.
Pathophysiology of the Disease
- The research explores the mechanisms that lead to ulcerative keratitis. It aims to educate about the factors that cause the disease and how it affects the horse’s eye. The understanding of pathophysiology is crucial as it offers insights into the disease’s progression and helps in formulating disease-specific treatment strategies.
Clinical Signs of Ulcerative Keratitis
- The article outlines the signs and symptoms associated with ulcerative keratitis in horses. Identification of these clinical signs plays a crucial role in early detection and treatment of the disease. Other than visual impairment, symptoms may include redness, tearing, squinting, and an apparent sensitivity to light.
Medical and Surgical Approaches
- The paper provides an in-depth understanding of contemporary medical and surgical approaches for treating bacterial and fungal ulcerative keratitis in horses. It illustrates how treatments have evolved over the years and the effectiveness of these methods.
- While medicinal approaches mostly include eye drops, ointments, or oral medication to fight infection and reduce inflammation, surgical options are typically considered for more severe or unresponsive cases. These may involve removing the damaged cornea or even transplantation.
Cite This Article
APA
Nasisse MP, Nelms S.
(1992).
Equine ulcerative keratitis.
Vet Clin North Am Equine Pract, 8(3), 537-555.
https://doi.org/10.1016/s0749-0739(17)30440-6 Publication
Researcher Affiliations
- Department of Companion Animal and Special Species Medicine, North Carolina State University College of Veterinary Medicine, Raleigh.
MeSH Terms
- Animals
- Corneal Ulcer / etiology
- Corneal Ulcer / therapy
- Corneal Ulcer / veterinary
- Eye Infections, Bacterial / etiology
- Eye Infections, Bacterial / therapy
- Eye Infections, Bacterial / veterinary
- Eye Infections, Fungal / etiology
- Eye Infections, Fungal / therapy
- Eye Infections, Fungal / veterinary
- Horse Diseases / etiology
- Horse Diseases / therapy
- Horses
References
This article includes 41 references
Citations
This article has been cited 11 times.- Stolle LM, Oltmanns H, Meißner J, Heun F, Schieder AK, Wolff HT, Ohnesorge B, Busse C. Polyhexanide, Povidone-Iodine, and Hypochlorous Acid Show High In Vitro Antimicrobial Efficacy Against Pathogens Commonly Associated With Equine Infectious Keratitis. Vet Ophthalmol 2026 Jan;29(1):e70141.
- Timmerman I, Robert MC, Vergneau-Grosset C, Juette T, Benito J, Garbin M, Zamani-Roudbaraki M, Moradi M, Goodarzi H, Boutopoulos C, Benoit-Biancamano MO, Griffith M, Vanore M. Biosynthetic Collagen-Analog Hydrogels Stimulate Endogenous Regrowth of Rabbit Corneas: A Pilot Study. Vet Sci 2025 Aug 21;12(8).
- Hosny OH, Abd-Elkareem M, Ali MM, Ahmed AF. Advanced platelet-rich fibrin promotes healing of induced corneal ulcer in donkeys (Equus asinus). Sci Rep 2023 Dec 9;13(1):21824.
- Cullen MA, Fentiman KE, Shaw GC, Rankin AJ. Report of a self-resolving corneal viral papilloma in a dog. Can Vet J 2023 Feb;64(2):123-126.
- Lores M, Rakestraw P, De Rijck M, Yarbrough T. Use of autologous fascia lata graft to repair a complex corneal ulcer in a mare. Ir Vet J 2020;73:7.
- Tamura N, Okano A, Kuroda T, Niwa H, Kusano K, Matsuda Y, Fukuda K, Mita H, Nagata S. Utility of systemic voriconazole in equine keratomycosis based on pharmacokinetic-pharmacodynamic analysis of tear fluid following oral administration. Vet Ophthalmol 2020 Jul;23(4):640-647.
- Sherman AB, Gilger BC, Berglund AK, Schnabel LV. Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro. Stem Cell Res Ther 2017 May 25;8(1):120.
- Fink MK, Giuliano EA, Tandon A, Mohan RR. Therapeutic potential of Pirfenidone for treating equine corneal scarring. Vet Ophthalmol 2015 May;18(3):242-50.
- Buss DG, Giuliano E, Sharma A, Mohan RR. Gene delivery in the equine cornea: a novel therapeutic strategy. Vet Ophthalmol 2010 Sep;13(5):301-6.
- Buss DG, Sharma A, Giuliano EA, Mohan RR. Efficacy and safety of mitomycin C as an agent to treat corneal scarring in horses using an in vitro model. Vet Ophthalmol 2010 Jul;13(4):211-8.
- Hartley C. Treatment of corneal ulcers: what are the medical options?. J Feline Med Surg 2010 May;12(5):384-97.
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