Estimated prevalence of polysaccharide storage myopathy among overtly healthy Quarter Horses in the United States.
Abstract: To estimate the prevalence of polysaccharide storage myopathy (PSSM) among Quarter Horses in the United States and evaluate possible relationships between muscle glycogen concentration, turnout time, and exercise level. Methods: Cross-sectional study. Methods: 164 overtly healthy Quarter Horses > 2 years old from 5 states. Methods: Horses with a history of exertional rhabdomyolysis or any other muscular disease were excluded. Muscle biopsy specimens were examined histologically for evidence of PSSM and were submitted for determination of muscle glycogen concentration. A diagnosis of PSSM was made if amylase-resistant inclusions that stained with periodic acid-Schiff stain were detected. Results: Prevalences of PSSM on the 2 farms with a history of PSSM were 20% (1/5) and 40.7% (11/27); mean prevalence for the other 4 farms was 6.1% (8/132). Sex was not significantly associated with a diagnosis of PSSM, and age was not significantly different between horses with and without PSSM. Total histologic score, serum creatine kinase activity, and muscle glycogen concentration were significantly higher in horses with PSSM than in horses without. Conclusions: Results suggested that the prevalence of PSSM among overtly healthy Quarter Horses in the United States is likely to be between 6% and 12%.
Publication Date: 2007-09-04 PubMed ID: 17764437DOI: 10.2460/javma.231.5.746Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research aimed to determine the prevalence of Polysaccharide Storage Myopathy (PSSM) among healthy Quarter Horses in the United States and analyze its relationship to muscle glycogen concentration, turnout time, and exercise level. The findings show that the prevalence of PSSM among Quarter Horses is likely to be between 6% to 12%.
Study Details
- The study was cross-sectional in design and involved 164 overtly healthy Quarter Horses that were over two years old, taken from 5 states in the United States.
- Horses with a history of exertional rhabdomyolosis or any other muscular disease were excluded from the study.
- Muscle biopsy specimens were examined histologically for evidence of PSSM and were submitted for the determination of muscle glycogen concentration.
- A diagnosis of PSSM was made if amylase-resistant inclusions that stained with periodic acid-Schiff stain were detected.
Results
- On two farms that had a history of PSSM, the prevalences were 20% (1 out of 5 horses) and 40.7% (11 out of 27 horses) respectively.
- The mean prevalence for the other four farms was calculated to be 6.1% (8 out of 132 horses).
- The sex of the horses was not significantly associated with a diagnosis of PSSM, and the age did not differ significantly between horses with and without PSSM.
- Total histologic score, serum creatine kinase activity, and muscle glycogen concentration were found to be significantly higher in horses with PSSM than in horses without it.
Conclusion
- The study’s results suggest that the prevalence of PSSM among otherwise healthy Quarter Horses in the United States could be between 6% and 12%.
Cite This Article
APA
McCue ME, Valberg SJ.
(2007).
Estimated prevalence of polysaccharide storage myopathy among overtly healthy Quarter Horses in the United States.
J Am Vet Med Assoc, 231(5), 746-750.
https://doi.org/10.2460/javma.231.5.746 Publication
Researcher Affiliations
- Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
MeSH Terms
- Animals
- Creatine Kinase / metabolism
- Cross-Sectional Studies
- Female
- Glycogen / metabolism
- Glycogen Storage Disease / epidemiology
- Glycogen Storage Disease / metabolism
- Glycogen Storage Disease / veterinary
- Horse Diseases / epidemiology
- Horse Diseases / metabolism
- Horses
- Male
- Muscle, Skeletal / metabolism
- Physical Conditioning, Animal / physiology
- Prevalence
- United States / epidemiology
Citations
This article has been cited 3 times.- Corley KTT. Metabolic disorders in foals. Equine Vet Educ 2012 Aug;24(8):392-395.
- Barrey E, Mucher E, Jeansoule N, Larcher T, Guigand L, Herszberg B, Chaffaux S, Guérin G, Mata X, Benech P, Canale M, Alibert O, Maltere P, Gidrol X. Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions. BMC Vet Res 2009 Aug 7;5:29.
- McCue ME, Valberg SJ, Miller MB, Wade C, DiMauro S, Akman HO, Mickelson JR. Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis. Genomics 2008 May;91(5):458-66.
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