Estimation of genetic parameters for the prevalence of osseous fragments in limb joints of Hanoverian Warmblood horses.
Abstract: Genetic parameters were estimated for the prevalence of osseous fragments in distal (DIJ) and proximal interphalangeal (PIJ), fetlock (FJ) and hock joints (HJ) of Hanoverian Warmblood horses by using residual maximum likelihood (REML) with linear animal models. The analyses were based on the results of 10 standardized radiographs of all four limbs of 3725 young riding horses selected for sale at auction. Transformation factors onto the underlying liability scale were verified by a simulation study. The heritability estimates of osseous fragments on the liability scale were in the range of h2 = 0.19-0.60. Further analyses of osseous fragments in FJ and HJ were performed separately in males and females. In both sexes, the heritabilities of osseous fragments in HJ were higher (h2 = 0.41 in males, h2 = 0.25 in females) than those of osseous fragments in FJ (h2 = 0.21 in males, h2 = 0.23 in females). Osseous fragments in the phalangeal joints (DIJ, PIJ, FJ) were genetically correlated moderately positive (r(g) = 0.19-0.41). The genetic correlations between osseous fragments in the phalangeal joints and in HJ were negative (r(g) = -0.27 to -0.67). Particularly, this applied to osseous fragments in FJ in both sexes, to those in front FJ in males and to osseous fragments in front and hind FJ of females (up to r(g) = -1). The heritability of height at withers was estimated at h2 = 0.27-0.28. Genetic correlations between height at withers and osseous fragments in equine limb joints were mostly moderately positive (up to r(g) = 0.75). We conclude from our results that osseous fragments in phalangeal and hock joints are genetically different traits but sex-specific expression of osseous fragments was unlikely.
Publication Date: 2005-08-03 PubMed ID: 16060495DOI: 10.1111/j.1439-0388.2005.00527.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research study evaluated the genetic factors influencing the occurrence of osseous fragments in certain limb joints of Hanoverian Warmblood horses. By studying radiographs of young horses selected for auction, the study found that the presence of osseous fragments in particular joints has heritability range between 0.19-0.60, therefore it’s an inheritable trait. The study also determined negative genetic correlation between osseous fragments in the phalangeal joints and in the hock joint.
Methodology
- The study was performed on Hanoverian Warmblood horses, chosen based off of the readiness for sale at auction.
- The research included analyzing 10 standardized radiographs of all four limbs from 3725 young riding horses.
- The researchers used residual maximum likelihood (REML) with linear animal models to estimate the genetic parameters for the occurrence of osseous fragments in distal and proximal interphalangeal, fetlock and hock joints.
Findings
- The heritability of having osseous fragments in the limbs was found to range between 0.19 and 0.60. This suggests that osseous fragments can definitely be an inherited trait.
- Osseous fragments in hock joints were found to have higher heritability in both sexes (0.41 in males, 0.25 in females), when compared to the fetlock joints (0.21 in males, 0.23 in females).
- The genetic correlation of osseous fragments in the phalangeal joints was found to be moderately positive (0.19-0.41).
- A negative correlation was discovered between osseous fragments in the phalangeal joints and in the hock joint (ranging from -0.27 to -0.67).
- Additionally, the study also found that there is moderate positive genetic correlation between height at withers and the occurrence of osseous fragments in equine limb joints.
Conclusion
- The research concludes the heritable nature of the occurrence of osseous fragments in different joints of Hanoverian Warmblood horses.
- The findings also differentiate the genetic traits of osseous fragments in the phalangeal and hock joints, indicating they are distinct genetic traits.
- However, the study found that the manifestation of these fragments was unlikely to be influenced by the sex of the horses.
Cite This Article
APA
Stock KF, Hamann H, Distl O.
(2005).
Estimation of genetic parameters for the prevalence of osseous fragments in limb joints of Hanoverian Warmblood horses.
J Anim Breed Genet, 122(4), 271-280.
https://doi.org/10.1111/j.1439-0388.2005.00527.x Publication
Researcher Affiliations
- Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany. kathrin-friederike.stock@tiho-hannover.de
MeSH Terms
- Animals
- Body Size / genetics
- Breeding
- Computer Simulation
- Female
- Forelimb
- Horse Diseases / epidemiology
- Horse Diseases / genetics
- Horses
- Joint Diseases / epidemiology
- Joint Diseases / genetics
- Joint Diseases / veterinary
- Likelihood Functions
- Linear Models
- Male
- Models, Genetic
- Osteochondritis Dissecans / complications
- Osteochondritis Dissecans / genetics
- Osteochondritis Dissecans / veterinary
- Prevalence
- Sex Factors
- Tarsus, Animal
Citations
This article has been cited 7 times.- Zimmermann E, Distl O. SNP-Based Heritability of Osteochondrosis Dissecans in Hanoverian Warmblood Horses. Animals (Basel) 2023 Apr 25;13(9).
- Shin J, Lee J, Cho J, Dang C, Choi T, Do C, Lee J, Lee S. The Estimation of Genetic Parameters for Longevity According to Lactation Period Using a Multiple Trait Animal Model in Korean Holstein Cows. Animals (Basel) 2022 Mar 11;12(6).
- Ripolles M, Sánchez-Guerrero MJ, Perdomo-González DI, Azor P, Valera M. Survey of Risk Factors and Genetic Characterization of Ewe Neck in a World Population of Pura Raza Español Horses. Animals (Basel) 2020 Oct 1;10(10).
- Büttgen L, Geibel J, Simianer H, Pook T. Simulation Study on the Integration of Health Traits in Horse Breeding Programs. Animals (Basel) 2020 Jul 7;10(7).
- Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. Anim Genet 2019 Dec;50(6):569-597.
- Dierks C, Löhring K, Lampe V, Wittwer C, Drögemüller C, Distl O. Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses. Mamm Genome 2007 Oct;18(10):739-47.
- Stock KF, Distl O, Hoeschele I. Bayesian estimation of genetic parameters for multivariate threshold and continuous phenotypes and molecular genetic data in simulated horse populations using Gibbs sampling. BMC Genet 2007 May 9;8:19.
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