Evaluation of a bioresorbable hyaluronate-carboxymethylcellulose membrane for prevention of experimentally induced abdominal adhesions in horses.
Abstract: To evaluate the efficacy of a bioresorbable hyaluronate-carboxymethylcellulose membrane (HA-membrane) for prevention of experimentally induced abdominal adhesions in horses. Methods: Experimental study. Methods: Twelve healthy adult horses. Methods: The effect of an HA-membrane on adhesion formation was evaluated in 12 healthy horses using an established model of serosal trauma to induce adhesions. A ventral median celiotomy and two jejunal resections and end-to-end anastomoses were performed. Two separate jejunal areas were abraded, and three 2-0 chromic gut sutures placed in the abraded areas. In treated horses (n = 6), HA-membranes were applied to the jejunum to completely cover the anastomoses and abraded areas of jejunum. Nontreated horses (n = 6) served as controls. All horses were killed 10 days after surgery. The abdominal cavity was evaluated for adhesion formation. The frequency of intra-abdominal adhesions between groups was compared with a chi2 test with statistical significance set at P < .05. Results: All control horses had intra-abdominal adhesions; fibrous adhesions were associated with both jejunal abrasion sites in 5 horses. One treated horse developed adhesions. There were significantly fewer adhesions in the HA-membrane-treated group (P < .0034). Conclusions: In this experimental model, application of an HA-membrane to a localized area of serosal trauma reduced the frequency of intra-abdominal adhesion formation. Conclusions: Application of an HA membrane may decrease the frequency of adhesions in horses at an increased risk of postoperative adhesion formation.
Publication Date: 2000-02-01 PubMed ID: 10653494DOI: 10.1111/j.1532-950x.2000.00048.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research studied the effectiveness of a specialized membrane in preventing abdominal adhesions in horses following surgical procedures that typically lead to such complications. The membrane made from hyaluronate-carboxymethylcellulose showed a significantly reduced occurrence of adhesions when compared to the control group.
Methodology
- The research utilized a standard model of serosal injury to stimulate adhesions in twelve healthy horses.
- Two surgeries involving ventral median celiotomy and two jejunal resections were performed on each horse in addition to abrading two disparate areas in the jejunum and suturing the abraded areas with 2-0 chromic gut sutures.
- In six treated horses, biodegradable hyaluronate-carboxymethylcellulose (HA) membranes were applied completely covering the anastomoses and the abraded jejunal areas.
- The remaining six horses that did not receive the HA-membrane treatment acted as control.
- After 10 days post-surgery, all horses were euthanized and their abdominal cavities investigated for the occurrence of adhesions.
- The occurrence of intra-abdominal adhesions in the two groups was analyzed using a chi-square test with a significance level set at P < .05.
Findings
- All control horses developed intra-abdominal adhesions, with fibrous adhesions associated with both jejunal abrasion sites in five of the horses.
- Only one horse from the treated group developed adhesions.
- The study found a significant reduction in the occurrence of adhesions in the group treated with the HA membrane (P < .0034).
Conclusions
- The results suggest that applying an HA-membrane to localized areas of serosal trauma can significantly decrease the instance of intra-abdominal adhesion formation.
- The use of an HA-membrane might reduce the frequency of adhesions in horses at a higher risk of developing postoperative adhesion complications.
Cite This Article
APA
Mueller PO, Hay WP, Harmon B, Amoroso L.
(2000).
Evaluation of a bioresorbable hyaluronate-carboxymethylcellulose membrane for prevention of experimentally induced abdominal adhesions in horses.
Vet Surg, 29(1), 48-53.
https://doi.org/10.1111/j.1532-950x.2000.00048.x Publication
Researcher Affiliations
- Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA. emueller@calc.vet.uga.edu
MeSH Terms
- Abdomen
- Anastomosis, Surgical / veterinary
- Animals
- Biocompatible Materials / therapeutic use
- Carboxymethylcellulose Sodium / therapeutic use
- Disease Models, Animal
- Horses / injuries
- Horses / surgery
- Hyaluronic Acid / therapeutic use
- Jejunal Diseases / prevention & control
- Jejunal Diseases / veterinary
- Jejunum / surgery
- Membranes, Artificial
- Postoperative Complications / prevention & control
- Postoperative Complications / veterinary
- Random Allocation
- Tissue Adhesions / prevention & control
- Tissue Adhesions / veterinary
- Wound Healing
Citations
This article has been cited 3 times.- Lillich JD, Ray-Miller W, Silver KS, Davis EG, Schultz BD. Intra-abdominal hyaluronan concentration in peritoneal fluid of horses with sudden signs of severe abdominal pain.. Am J Vet Res 2011 Dec;72(12):1666-73.
- Yelimlieş B, Alponat A, Cubukçu A, Kuru M, Oz S, Erçin C, Gönüllü N. Carboxymethylcellulose coated on visceral face of polypropylene mesh prevents adhesion without impairing wound healing in incisional hernia model in rats.. Hernia 2003 Sep;7(3):130-3.
- Wang XC, Gui CQ, Zheng QS. Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis.. World J Gastroenterol 2003 Mar;9(3):568-71.
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